Results 11 to 20 of about 16,352,795 (292)
Complement factor H in molecular regulation of angiogenesis [PDF]
Medical ReviewAngiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang +6 more
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Factor H Autoantibodies and Complement-Mediated Diseases [PDF]
Frontiers in Immunology, 2020 Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang +10 more
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Hijacking Factor H for Complement Immune Evasion [PDF]
Frontiers in Immunology, 2021 The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore +3 more
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Properdin and Factor H: Opposing players on the alternative complement pathway see-saw [PDF]
Frontiers in Immunology, 2013 Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser +7 more
doaj +2 more sources
The complement factor H‐related proteins
Immunological Reviews, 2016 SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR
Medjeral-Thomas, N, Pickering, MC
openaire +4 more sources
Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H [PDF]
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
doaj +4 more sources
Recombinant complement factor H in complement-mediated diseases [PDF]
, 2022 Complement Factor H (FH) is a 155-kDa plasma glycoprotein that regulates the alternative pathway of the complement system. Mutations or deficiencies in FH are associated with some cases of the kidney diseases C3 glomerulopathy and atypical haemolytic uraemic syndrome (aHUS).
Kerr, Heather
openaire +4 more sources
, 2012 Complement factor H (fH) is a single chain plasma glycoprotein (approximately 150 kDa in size), with 20 domains termed complement control protein (CCP) domains or short consensus repeats (SCR). The complement factor H gene (CFH) is located on chromosome 1q32 in the regulators of complement activation (RCA) gene cluster, adjacent to the genes that code ...
Dinasarapu, Ashok Reddy +3 more
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Differential modulation of SARS-CoV-2 infection by complement factor H and properdin [PDF]
Frontiers in ImmunologyIntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore +17 more
doaj +2 more sources
Editorial: Function and Dysfunction of Complement Factor H [PDF]
Frontiers in Immunology, 2022 Non peer ...
Mihály Józsi +2 more
doaj +6 more sources