Results 11 to 20 of about 2,568,825 (335)

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H [PDF]

Frontiers in Immunology, 2020
Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig, Anne K. Mühlig, Lindsay S. Keir, Jana C. Abt, Hannah S. Heidelbach, Rachel Horton, Gavin I. Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J. Coward, Lars Fester, Lars Fester, Moin A. Saleem, Jun Oh, Jun Oh   +14 more
doaj   +6 more sources

Editorial: Function and Dysfunction of Complement Factor H [PDF]

Frontiers in Immunology, 2022
Non peer ...
Mihály Józsi, Paul Nigel Barlow, Seppo Meri   +2 more
doaj   +9 more sources

Complement factor H in molecular regulation of angiogenesis [PDF]

Medical Review
Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang, Wang Kaili, Starodubtseva Maria N., Nadyrov Eldar, Kapron Carolyn M., Hoh Josephine, Liu Ju   +6 more
doaj   +4 more sources

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Frontiers in Immunology, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Zoltán Prohászka, Anna Erdei, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi, Mihály Józsi   +16 more
doaj   +2 more sources

Hijacking Factor H for Complement Immune Evasion [PDF]

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +3 more sources

Factor H Autoantibodies and Complement-Mediated Diseases [PDF]

Frontiers in Immunology, 2020
Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang, Nicolo Ghiringhelli Borsa, Dingwu Shao, Arthur Dopler, Michael B. Jones, Nicole C. Meyer, Gabriella R. Pitcher, Amanda O. Taylor, Carla M. Nester, Christoph Q. Schmidt, Richard J. H. Smith   +10 more
doaj   +4 more sources

Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Frontiers in Immunology, 2021
Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD).
Nicole Schäfer, Nicole Schäfer, Anas Rasras, Anas Rasras, Delia M. Ormenisan, Sabine Amslinger, Volker Enzmann, Herbert Jägle, Diana Pauly, Diana Pauly   +9 more
doaj   +2 more sources

Human complement factor H [PDF]

, 1986
We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Dierich, Manfred P., Schulz, T. F., Schwaeble, W., Stanley, K. K., Weiss, Elisabeth H.   +4 more
core   +3 more sources

Microbes bind complement inhibitor factor H via a common site. [PDF]

PLoS Pathogens, 2013
To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri, H Amdahl, M J Lehtinen, S Hyvärinen, J V McDowell, A Bhattacharjee, S Meri, R Marconi, A Goldman, T S Jokiranta   +9 more
doaj   +11 more sources

Properdin and Factor H: Opposing players on the alternative complement pathway see-saw [PDF]

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser, Munirah eAbdul-Aziz, Munirah eAbdul-Aziz, Annapurna eNayak, Cordula M Stover, Robert B Sim, Robert B Sim, Uday eKishore   +7 more
doaj   +3 more sources