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Microbes bind complement inhibitor factor H via a common site. [PDF]
PLoS Pathogens, 2013 To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
T Meri +9 more
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Nefrología, 2022 Resumen: El sistema del Complemento protege al organismo frente a procesos infecciosos, tumorales y autoinmunes, y requiere una regulación muy estricta para evitar una activación excesiva o inespecífica.
Irene Gómez Delgado +1 more
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Complement factors (H) into thrombosis [PDF]
Blood, 2017 In this issue of Blood, Ueda et al demonstrate that a mutation in factor H (FH) disrupts host cell interactions, leading to dysregulation of complement, systemic thrombotic angiopathy, and hemolytic uremic syndrome ...
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Complement and coagulation crosstalk – Factor H in the spotlight
Immunobiology, 2023 The immune complement and the coagulation systems are blood-based proteolytic cascades that are activated by pathway-specific triggers, based on protein-protein interactions and enzymatic cleavage reactions. Activation of these systems is finely balanced and controlled through specific regulatory mechanisms.
Meike Heurich, Geneviève McCluskey
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Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children
Frontiers in Immunology, 2018 Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek +10 more
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Myeloperoxidase influences the complement regulatory activity of complement factor H [PDF]
Rheumatology, 2018 The interaction between neutrophils and activation of alternative complement pathway plays a critical role in the pathogenesis of ANCA-associated vasculitis (AAV). MPO, which can be released from ANCA-stimulated neutrophils, was recently demonstrated to be capable of activating the alternative complement pathway.
Su-Fang, Chen +5 more
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Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H [PDF]
Clinical and Experimental Immunology, 2007 SummaryOTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON COMPLEMENT FACTOR HStructural and functional correlations for factor H. Clin Exp Immunol 2008; 151: doi:10.1111/j.1365-2249.2007.03553.xTherapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative ...
Rodríguez de Córdoba, Santiago +1 more
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Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström +14 more
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PLoS ONE, 2021 Exosomes are a class of extracellular vesicles (EVs) that are mediators of normal intercellular communication, but exosomes are also used by tumor cells to promote oncogenesis and metastasis.
Ryan T Bushey +3 more
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Factor H preserves alternative complement function during ARDS, linked to improved survival
ERJ Open Research, 2023 Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain +11 more
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