Results 21 to 30 of about 344,456 (259)
PLoS ONE, 2021 Exosomes are a class of extracellular vesicles (EVs) that are mediators of normal intercellular communication, but exosomes are also used by tumor cells to promote oncogenesis and metastasis.
Ryan T Bushey +3 more
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Factor H preserves alternative complement function during ARDS, linked to improved survival
ERJ Open Research, 2023 Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain +11 more
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Myeloperoxidase influences the complement regulatory activity of complement factor H [PDF]
Rheumatology, 2018 The interaction between neutrophils and activation of alternative complement pathway plays a critical role in the pathogenesis of ANCA-associated vasculitis (AAV). MPO, which can be released from ANCA-stimulated neutrophils, was recently demonstrated to be capable of activating the alternative complement pathway.
Su-Fang, Chen +5 more
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Complement and coagulation crosstalk – Factor H in the spotlight
Immunobiology, 2023 The immune complement and the coagulation systems are blood-based proteolytic cascades that are activated by pathway-specific triggers, based on protein-protein interactions and enzymatic cleavage reactions. Activation of these systems is finely balanced and controlled through specific regulatory mechanisms.
Meike Heurich, Geneviève McCluskey
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Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H [PDF]
Clinical and Experimental Immunology, 2007 SummaryOTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON COMPLEMENT FACTOR HStructural and functional correlations for factor H. Clin Exp Immunol 2008; 151: doi:10.1111/j.1365-2249.2007.03553.xTherapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative ...
Rodríguez de Córdoba, Santiago +1 more
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Complement factor H and the hemolytic uremic syndrome [PDF]
The Journal of Experimental Medicine, 2007 Immune recognition is coupled to powerful proinflammatory effector pathways that must be tightly regulated. The ancient alternative pathway of complement activation is one such proinflammatory pathway. Genetic susceptibility factors have been identified in both regulators and activating components of the alternative pathway that are associated with ...
Atkinson, John P, Goodship, Timothy H.J.
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Virulence, 2020 Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we
Yanfei Yu +11 more
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Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions
Frontiers in Immunology, 2021 Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti +7 more
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Frontiers in Microbiology, 2015 The virulence factor PgtE is an outer membrane protease (omptin) of the zoonotic pathogen Salmonella enterica that causes diseases ranging from gastroenteritis to severe enteric fever. It is surface exposed in bacteria that have a short-chain, i.e. rough
Rauna eRiva +2 more
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Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?
Haseki Tıp Bülteni, 2020 Aim:Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (
Sacide Pehlivan +4 more
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