Results 21 to 30 of about 16,352,795 (292)

Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?

Haseki Tıp Bülteni, 2020
Aim:Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (
Sacide Pehlivan, Mazlum Serdar Akaltun, Mustafa Pehlivan, Savaş Gürsoy, Ayşe Feyda Nursal   +4 more
doaj   +2 more sources

Human complement factor H [PDF]

, 1986
We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression
Schulz, T. F., Schwaeble, W., Stanley, K. K., Weiss, Elisabeth H., Dierich, Manfred P.   +4 more
openaire   +3 more sources

Protective role of complement factor H against the development of preeclampsia [PDF]

Frontiers in Immunology
Pregnancy is an immunologically regulated, complex process. A tightly controlled complement system plays a crucial role in the successful establishment of pregnancy and parturition.
Hadida Yasmin, Chiara Agostinis, Miriam Toffoli, Tamali Roy, Silvia Pegoraro, Andrea Balduit, Gabriella Zito, Nicoletta Di Simone, Nicoletta Di Simone, Giuseppe Ricci, Giuseppe Ricci, Taruna Madan, Uday Kishore, Uday Kishore, Roberta Bulla   +14 more
doaj   +2 more sources

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy [PDF]

Frontiers in Cell and Developmental Biology
The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression.
Ruchi Saxena, Elizabeth B. Gottlin, Michael J. Campa, Ryan T. Bushey, Jian Guo, Edward F. Patz, Edward F. Patz, You-Wen He   +7 more
doaj   +2 more sources

Complement-Independent Modulation of Influenza A Virus Infection by Factor H [PDF]

Frontiers in Immunology, 2020
The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface ...
Valarmathy Murugaiah, Praveen M. Varghese, Praveen M. Varghese, Soad M. Saleh, Anthony G. Tsolaki, Salman H. Alrokayan, Haseeb A. Khan, Kate S. Collison, Robert B. Sim, Béatrice Nal, Futwan A. Al-Mohanna, Uday Kishore   +11 more
doaj   +2 more sources

C3 Glomerulonephritis associated with Anti-complement Factor H Autoantibodies in an Adolescent Male: A Case Report [PDF]

Childhood Kidney Diseases, 2021
C3 glomerulonephritis (C3GN), a rare condition associated with dysregulation of the alternative pathway of the complement system, is histopathologically characterized by isolated or dominant C3 deposition in the renal glomeruli.
HyeSun Hyun, Hee Gyung Kang, UiJu Cho, Il-Soo Ha, Hae Il Cheong   +4 more
doaj   +1 more source

Human complement factor H [PDF]

, 1991
Schwaeble, W., Feifel, E., Estaller, C., Barbieri, A., Molgg, M., Koistinen, V., Weiss, Elisabeth H., Dierich, Manfred P.   +7 more
openaire   +3 more sources

Plasma Complement factor H in Alzheimer's Disease

Journal of Alzheimer's Disease, 2015
Biomarkers for Alzheimer's disease (AD) should meet several criteria, including simplicity of testing. Inappropriate activation of the complement cascade has been implicated in the pathogenesis of AD. Complement factor H (CFH) is a regulator of the cascade, but studies on plasma CFH levels in AD have provided mixed results.
Williams, Michael A., Haughton, David, Stevenson, Michael, Craig, David, Passmore, A. Peter, Silvestri, Giuliana   +5 more
openaire   +4 more sources

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions

Computational and Structural Biotechnology Journal, 2023
Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable.
Natalia Ruiz-Molina, Juliana Parsons, Eva L. Decker, Ralf Reski   +3 more
doaj   +1 more source

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Frontiers in Immunology, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Zoltán Prohászka, Anna Erdei, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi, Mihály Józsi   +16 more
doaj   +1 more source