Results 21 to 30 of about 2,568,825 (335)

The complement factor H‐related proteins

Immunological Reviews, 2016
SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR
N. Medjeral-Thomas, M. Pickering
semanticscholar   +5 more sources

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin [PDF]

Frontiers in Immunology
IntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag   +17 more
doaj   +2 more sources

Myeloperoxidase influences the complement regulatory activity of complement factor H [PDF]

Rheumatology, 2018
The interaction between neutrophils and activation of alternative complement pathway plays a critical role in the pathogenesis of ANCA-associated vasculitis (AAV). MPO, which can be released from ANCA-stimulated neutrophils, was recently demonstrated to be capable of activating the alternative complement pathway.
Su-Fang Chen, Feng-mei Wang, Zhi-Ying Li, F. Yu, Min Chen, Ming-hui Zhao   +5 more
semanticscholar   +3 more sources

Protective role of complement factor H against the development of preeclampsia [PDF]

Frontiers in Immunology
Pregnancy is an immunologically regulated, complex process. A tightly controlled complement system plays a crucial role in the successful establishment of pregnancy and parturition.
Hadida Yasmin, Chiara Agostinis, Miriam Toffoli, Tamali Roy, Silvia Pegoraro, Andrea Balduit, Gabriella Zito, Nicoletta Di Simone, Nicoletta Di Simone, Giuseppe Ricci, Giuseppe Ricci, Taruna Madan, Uday Kishore, Uday Kishore, Roberta Bulla   +14 more
doaj   +2 more sources

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy [PDF]

Frontiers in Cell and Developmental Biology
The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression.
Ruchi Saxena, Elizabeth B. Gottlin, Michael J. Campa, Ryan T. Bushey, Jian Guo, Edward F. Patz, Edward F. Patz, You-Wen He   +7 more
doaj   +2 more sources

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. [PDF]

PLoS Genetics, 2011
Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated with increased complement activation. Variants of genes encoding complement regulator factor H (CFH) and five CFH-related proteins (CFHR1-CFHR5) within the ...
Jian Zhao, Hui Wu, Melanie Khosravi, Huijuan Cui, Xiaoxia Qian, Jennifer A Kelly, Kenneth M Kaufman, Carl D Langefeld, Adrienne H Williams, Mary E Comeau, Julie T Ziegler, Miranda C Marion, Adam Adler, Stuart B Glenn, Marta E Alarcón-Riquelme, BIOLUPUS Network, GENLES Network, Bernardo A Pons-Estel, John B Harley, Sang-Cheol Bae, So-Young Bang, Soo-Kyung Cho, Chaim O Jacob, Timothy J Vyse, Timothy B Niewold, Patrick M Gaffney, Kathy L Moser, Robert P Kimberly, Jeffrey C Edberg, Elizabeth E Brown, Graciela S Alarcon, Michelle A Petri, Rosalind Ramsey-Goldman, Luis M Vilá, John D Reveille, Judith A James, Gary S Gilkeson, Diane L Kamen, Barry I Freedman, Juan-Manuel Anaya, Joan T Merrill, Lindsey A Criswell, R Hal Scofield, Anne M Stevens, Joel M Guthridge, Deh-Ming Chang, Yeong Wook Song, Ji Ah Park, Eun Young Lee, Susan A Boackle, Jennifer M Grossman, Bevra H Hahn, Timothy H J Goodship, Rita M Cantor, Chack-Yung Yu, Nan Shen, Betty P Tsao   +56 more
doaj   +4 more sources

Human complement factor H [PDF]

, 1987
Dierich, Manfred P., Linke, Reinhold P., Schulz, T. F., Schwaeble, Wilhelm, Weiss, Elisabeth H., Zwirner, Jörg   +5 more
core   +3 more sources

C3 Glomerulonephritis associated with Anti-complement Factor H Autoantibodies in an Adolescent Male: A Case Report [PDF]

Childhood Kidney Diseases, 2021
C3 glomerulonephritis (C3GN), a rare condition associated with dysregulation of the alternative pathway of the complement system, is histopathologically characterized by isolated or dominant C3 deposition in the renal glomeruli.
HyeSun Hyun, Hee Gyung Kang, UiJu Cho, Il-Soo Ha, Hae Il Cheong   +4 more
doaj   +1 more source

Interlink between Inflammation and Oxidative Stress in Age-Related Macular Degeneration: Role of Complement Factor H

Biomedicines, 2021
Age-related macular degeneration (AMD) heads the list of legal blindness among the elderly population in developed countries. Due to the complex nature of the retina and the variety of risk factors and mechanisms involved, the molecular pathways ...
Sara Romero-Vázquez, V. Llorens, Alba Soler-Boronat, M. Figueras-Roca, A. Adán, B. Molins   +5 more
semanticscholar   +1 more source

Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H

Journal of Immunology, 2021
Key Points FXIa cleaves CFH at the R341/R342 bonds at the end of the CCP 6 domain of CFH. FXIa reduces CFH cofactor and decay‐accelerating activity and binding to ECs. CFH binds FXI and inhibits FXI activation by either thrombin or FXIIa.
C. Puy, J. Pang, Stéphanie E. Reitsma, C. Lorentz, E. Tucker, D. Gailani, A. Gruber, F. Lupu, O. McCarty   +8 more
semanticscholar   +1 more source