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The Emerging Roles of Extracellular Chaperones in Complement Regulation [PDF]

Cells, 2022
The immune system is essential to protect organisms from internal and external threats. The rapidly acting, non-specific innate immune system includes complement, which initiates an inflammatory cascade and can form pores in the membranes of target cells
Nicholas J. Geraghty, Sandeep Satapathy, Mark R. Wilson   +2 more
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Complement regulation: physiology and disease relevance [PDF]

Korean Journal of Pediatrics, 2015
The complement system is part of the innate immune response and as such defends against invading pathogens, removes immune complexes and damaged self-cells, aids organ regeneration, confers neuroprotection, and engages with the adaptive immune response ...
Heeyeon Cho
doaj   +2 more sources

Complement system in kidney transplantation: from innate immune surveillance to a therapeutic and genetic engineering target [PDF]

Frontiers in Immunology
Kidney transplantation remains the most effective treatment for end-stage kidney disease; however, long-term graft survival is constrained by rejection and chronic graft injury, and donor shortages continue to drive interest in xenotransplantation.
Yoichi Kakuta, Shuji Miyagawa, Shunsuke Mori, Soichi Matsumura, Masataka Kawamura, Shigeaki Nakazawa, Akira Maeda, Shunsuke Saito, Masahito Ikawa, Miho Watanabe, Shigeru Miyagawa, Norio Nonomura   +11 more
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Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation [PDF]

The Journal of Clinical Investigation
A greater understanding of chronic lung allograft dysfunction (CLAD) pathobiology, the primary cause of death after lung transplantation (LTx), is needed to improve outcomes.
Hrishikesh S. Kulkarni, Laneshia K. Tague, Daniel R. Calabrese, Fuyi Liao, Zhiyi Liu, Lorena Garnica, Nishanth R. Shankar, Xiaobo Wu, Devesha H. Kulkarni, Aayusha Thapa, Dequan Zhou, Yan Tao, Victoria E. Davis, Cory T. Bernardt, Derek E. Byers, Catherine Chen, Howard J. Huang, Chad A. Witt, Ramsey R. Hachem, Daniel Kreisel, John P. Atkinson, John R. Greenland, Andrew E. Gelman   +22 more
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Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots

Frontiers in Immunology
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang, Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Uday Kishore, Robert B. Sim   +7 more
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Complement evasion by apicomplexans: Convergent strategies across diverse parasites. [PDF]

PLoS Pathogens
Apicomplexan parasites encounter the complement system during extracellular stages of infection, where it imposes a major barrier to survival. Complement activation promotes pathogen elimination through opsonization, inflammation, and membrane attack ...
Sofía Espinosa-Hernández, Carlos J Ramírez-Flores   +1 more
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Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Frontiers in Immunology, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Zoltán Prohászka, Anna Erdei, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi, Mihály Józsi   +16 more
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Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE

Frontiers in Immunology, 2023
Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI degrades C3b, which inhibits further complement activation.
Alexandra Gerogianni, Alexandra Gerogianni, Laura M. Baas, Dick J. Sjöström, Dick J. Sjöström, Nicole C. A. J. van de Kar, Marit Pullen, Siem J. van de Peppel, Per H. Nilsson, Per H. Nilsson, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel   +13 more
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Modeling C3 glomerulopathies: C3 convertase regulation on an extracellular matrix surface

Frontiers in Immunology, 2023
IntroductionC3 glomerulopathies (C3G) are ultra-rare complement-mediated diseases that lead to end-stage renal disease (ESRD) within 10 years of diagnosis in ~50% of patients.
Sofiya Pisarenka, Sofiya Pisarenka, Nicole C. Meyer, Xue Xiao, Renee Goodfellow, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith, Richard J. H. Smith   +8 more
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Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator

Marine Drugs, 2020
Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate ...
Ilia A. Krenev, Ekaterina S. Umnyakova, Igor E. Eliseev, Yaroslav A. Dubrovskii, Nikolay P. Gorbunov, Vladislav A. Pozolotin, Alexei S. Komlev, Pavel V. Panteleev, Sergey V. Balandin, Tatiana V. Ovchinnikova, Olga V. Shamova, Mikhail N. Berlov   +11 more
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