Results 21 to 30 of about 2,965,220 (293)

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Sim, Robert B., Sloan, Jeremy, Green, Malcolm L.H., Sim, Edith, Salvador-Morales, Carolina, Green, Malcolm L. H.   +6 more
core   +1 more source

The salivary scavenger and agglutinin (SALSA) binds MBL and regulates the lectin pathway of complement in solution and on surfaces

Frontiers in Immunology, 2012
The scavenger receptor cysteine-rich (SRCR) protein SALSA, also known as gp340, salivary agglutinin (SAG) and deleted in malignant brain tumor 1 (DMBT1), is a 340 kDa glycoprotein expressed on mucosal surfaces and secreted into several body fluids. SALSA
Martin eParnov Reichhardt, Vuokko eLoimaranta, Steffen eThiel, Jukka eFinne, Seppo eMeri, Seppo eMeri, Hanna eJarva, Hanna eJarva   +7 more
doaj   +1 more source

The Role of Complement in Tumors

, 2020
The complement system is an essential part of the innate immune system that is responsible for regulating inflammation, facilitating immune defense mechanisms, and maintaining tissue homeostasis.

core   +1 more source

Complementing the sugar code: role of GAGs and sialic acid in complement regulation

Frontiers in Immunology, 2015
Sugar molecules play a vital role on both microbial and mammalian cells, where they are involved in cellular communication, govern microbial virulence and modulate host immunity and inflammatory responses.
Alex eLangford-Smith, Anthony John Day, Paul Nicholas Bishop, Paul Nicholas Bishop, Paul Nicholas Bishop, Simon John Clark, Simon John Clark   +6 more
doaj   +1 more source

Complement regulation of T-cell alloimmunity. [PDF]

Semin Nephrol, 2013
Complement proteins are generated both by the liver (systemic compartment) and by peripheral tissue-resident cells and migratory immune cells (local compartment). The immune cell-derived, alternative pathway complement components activate spontaneously, yielding local, but not systemic, production of C3a and C5a.
Cravedi P, van der Touw W, Heeger PS.
europepmc   +4 more sources

Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway [PDF]

The Journal of Experimental Medicine, 2001
We studied complement 1 inhibitor (C1-INH) as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, induced by the alternative complement pathway, of paroxysmal nocturnal hemoglobinuria (PNH) erythrocytes in human serum. It inhibited the binding of both factors B and C3 to PNH and rabbit erythrocytes and blocked the ability of ...
H, Jiang, E, Wagner, H, Zhang, M M, Frank   +3 more
openaire   +2 more sources

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi [PDF]

, 2010
Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B.
Teresia Hallström, Hallström Teresia, Christine Skerka, Beckhaus Tobias, Skerka, Christine, Karas Michael, Hannes Eberhardt, Michael Karas, Barbara Uzonyi, Corinna Siegel, Kraiczy Peter, Eberhardt, Hannes, Uzonyi Barbara, Zipfel, Peter F., Beckhaus, Tobias, Peter Kraiczy, Karas, Michael (Prof. Dr.), Stevenson, Brian, Peter F Zipfel, Stevenson Brian, Uzonyi, Barbara, Brian Stevenson, Peter F. Zipfel, Siegel, Corinna, Hallström, Teresia, Kraiczy, Peter, Tobias Beckhaus, Eberhardt Hannes, Skerka Christine, Wallich, Reinhard, Zipfel Peter F., Reinhard Wallich, Siegel Corinna, Karas, Michael, Wallich Reinhard   +34 more
core   +2 more sources

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426), Richter Dania, Kraiczy Peter, Schwab Jasmin, Skerka Christine, Hammerschmidt Claudia, Zipfel Peter F., Matuschka Franz-Rainer, Wallich Reinhard   +32 more
core   +1 more source

Interaction of Human Complement Factor H Variants Tyr402 and His 402 with Leptospira spp.

Frontiers in Immunology, 2011
Leptospirosis is a zoonosis caused by pathogenic bacteria from the genus Leptospira. The disease represents a serious public health problem in underdeveloped tropical countries.
Aldacilene Souza Silva, Mónica Marcela Castiblanco Valencia, Aurora Marques Cianciarullo, Silvio Arruda Vasconcellos, Angela Silva Barbosa, Lourdes eIsaac   +5 more
doaj   +1 more source

The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus

Cell Reports, 2023
Summary: Complement-dependent microglia pruning of excitatory synapses has been widely reported in physiological and pathological conditions, with few reports concerning pruning of inhibitory synapses or direct regulation of synaptic transmission by ...
Lang Wen, Xiaoli Yang, Zujun Wu, Shumei Fu, Yaxi Zhan, Zuolong Chen, Danlei Bi, Yong Shen   +7 more
doaj   +1 more source