Results 1 to 10 of about 8,199 (189)

A Novel Antibody against Human Properdin Inhibits the Alternative Complement System and Specifically Detects Properdin from Blood Samples [PDF]

PLoS ONE, 2014
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Bernhard Weber, Susanne Ackermann, Diana Pauly   +2 more
exaly   +4 more sources

Properdin oligomers adopt rigid extended conformations supporting function

eLife, 2021
Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis V Pedersen, Martin Nors Pedersen, Sofia MM Mazarakis, Yong Wang, Kresten Lindorff-Larsen, Lise Arleth, Gregers R Andersen   +6 more
doaj   +2 more sources

Properdin deficiency or anti-properdin treatment ameliorates disease in the C3 gain-of-function mouse model of atypical haemolytic uraemic syndrome. [PDF]

Front Immunol
IntroductionWe have previously shown that the C3D1115N mouse, engineered around a single point mutation in C3 associated with atypical haemolytic uraemic syndrome (aHUS) in man, fully recapitulates the clinical disease. In this study, we investigated the
Mallett G, Kamala O, Pappworth IY, Smith-Jackson K, Gibson BG, Asif M, Denton H, Cox C, Walsh P, Kavanagh D, Marchbank KJ.   +10 more
europepmc   +2 more sources

Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia. [PDF]

Front Immunol
IntroductionAberrant complement activation can cause damage to newly formed fetal-derived structures and excessive inflammatory response at the feto-maternal interface, contributing to pregnancy-related complications, including preeclampsia (PE), which ...
Yasmin H, Roy T, Agostinis C, Rao A, Sharma P, Toffoli M, Balduit A, Pegoraro S, Bindu S, Prasad R, Ricci G, Vatish M, Madan T, Bulla R, Kishore U.   +14 more
europepmc   +2 more sources

Differential expression of complement Properdin and Factor H in the placentae and umbilical cords of mothers with Preeclampsia, Gestational Diabetes Mellitus and Recurrent Pregnancy Loss. [PDF]

Front Immunol
BackgroundProperdin and factor H (FH), the two regulatory proteins of the alternative complement pathway, oppose each other to maintain the complement system’s activation.
Roy T, Das A, Chatterjee N, Saha SP, Prasad R, Madan T, Yasmin H, Kishore U.   +7 more
europepmc   +2 more sources

Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long-Term Cardiovascular Mortality. [PDF]

J Am Heart Assoc
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Louwe MC, Gialeli C, Michelsen AE, Holm S, Edsfeldt A, Skagen K, Lekva T, Olsen MB, Bjerkeli V, Schjørlien T, Stø K, Kong XY, Dahl TB, Nilsson PH, Libby P, Aukrust P, Mollnes TE, Ueland T, Skjelland M, Gonçalves I, Halvorsen B.   +20 more
europepmc   +2 more sources

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin. [PDF]

Front Immunol
IntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Kishore U, Varghese PM, Kumar C, Idicula-Thomas S, Mayora Neto M, Tsolaki AG, Ponnachan P, Masmoudi K, Al-Ramadi B, Vatish M, Madan T, Temperton N, Beirag N.   +12 more
europepmc   +2 more sources

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke

Journal of Neuroinflammation, 2023
Background Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia.
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao   +8 more
doaj   +1 more source

Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection

Frontiers in Immunology, 2021
The complement system is designed to recognise and eliminate invading pathogens via activation of classical, alternative and lectin pathways. Human properdin stabilises the alternative pathway C3 convertase, resulting in an amplification loop that leads ...
Praveen M. Varghese, Praveen M. Varghese, Shuvechha Mukherjee, Futwan A. Al-Mohanna, Souad M. Saleh, Fahad N. Almajhdi, Nazar Beirag, Saad H. Alkahtani, Reena Rajkumari, Beatrice Nal Rogier, Robert B. Sim, Susan Idicula-Thomas, Taruna Madan, Valarmathy Murugaiah, Uday Kishore   +14 more
doaj   +1 more source