Results 11 to 20 of about 8,199 (189)

Properdin levels in human sepsis

Frontiers in Immunology, 2015
Properdin is a normal serum protein which increases the production of complement activation products by binding to C3b integral to convertase complexes and amplifying their activity at the site of activation.
Cordula M Stover, John eMcDonald, Simon eByrne, David G Lambert, Jonathan eThompson   +4 more
doaj   +8 more sources

Properdin and Factor H: Opposing players on the alternative complement pathway see-saw [PDF]

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser, Munirah eAbdul-Aziz, Munirah eAbdul-Aziz, Annapurna eNayak, Cordula M Stover, Robert B Sim, Robert B Sim, Uday eKishore   +7 more
doaj   +2 more sources

Prognostic Value of Complement Properdin in Cancer [PDF]

Frontiers in Immunology, 2021
The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ...
Alessandro Mangogna, Praveen M. Varghese, Praveen M. Varghese, Chiara Agostinis, Salman H. Alrokayan, Haseeb A. Khan, Cordula M. Stover, Beatrice Belmonte, Anna Martorana, Giuseppe Ricci, Giuseppe Ricci, Roberta Bulla, Uday Kishore   +12 more
doaj   +2 more sources

Complement Properdin Determines Disease Activity in MRL/lpr Mice

Medicina, 2020
Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee, Azzah Alharbi, Zeayd Saeed, Róisín C. Thomas, Cordula M. Stover   +4 more
doaj   +2 more sources

Characterisation of the properdin-deficient immune phenotype

, 2018
Properdin (complement factor P) is a conserved serum glycoprotein of the immune defence. It plays a role in strengthening the activation of complement, a system of proteins important in the first line defence against infection. Properdin is active in the
Cordula M. Stover (7117046), Fatima Mohamed Makhlouf Mohamed (7782113)   +1 more
core   +7 more sources

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID. [PDF]

Immunology
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Keat SBK, Khatri P, Ali YM, Arachchilage CH, Demopulos G, Baillie K, Miners KL, Ladell K, Jones SA, Davies HE, Price DA, Zelek WM, Morgan BP, Schwaeble WJ, Lynch NJ.   +14 more
europepmc   +2 more sources

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease. [PDF]

Am J Hematol
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Allali S, Sbeih N, Rignault-Bricard R, Bruce J, Gall ML, Heilbronner C, de Cacqueray N, Angyalosy S, Taylor M, Brice J, de Montalembert M, Bevacqua M, Gautier EF, Hermine O, Maciel TT.   +14 more
europepmc   +2 more sources

Structural and functional characterisation of properdin and properdin-binding complement inhibitors from ticks [PDF]

, 2022
The complement system is a major effector of the immune response which can lead to opsonisation and inflammation, as well as the removal of immune complexes and damaged self-cells.
Ahn, Jiyoon
core   +1 more source

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Frontiers in Immunology, 2020
Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can
Rosa G. M. Lammerts, Ditmer T. Talsma, Wendy A. Dam, Mohamed R. Daha, Marc A. J. Seelen, Stefan P. Berger, Jacob van den Born   +6 more
doaj   +1 more source

The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa

Frontiers in Immunology, 2020
Properdin (P) is a positive regulatory protein that stabilizes the C3 convertase and C5 convertase of the complement alternative pathway (AP). Several studies have suggested that properdin can bind directly to the surface of certain pathogens regardless ...
Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P. Ferreira, Gurpanna Saggu, Angela Silva Barbosa, Lourdes Isaac   +7 more
doaj   +1 more source