Results 11 to 20 of about 6,251 (169)

Properdin deficiency or anti-properdin treatment ameliorates disease in the C3 gain-of-function mouse model of atypical haemolytic uraemic syndrome [PDF]

Frontiers in Immunology
IntroductionWe have previously shown that the C3D1115N mouse, engineered around a single point mutation in C3 associated with atypical haemolytic uraemic syndrome (aHUS) in man, fully recapitulates the clinical disease. In this study, we investigated the
Grace Mallett, Grace Mallett, Ola Kamala, Ola Kamala, Isabel Y. Pappworth, Isabel Y. Pappworth, Kate Smith-Jackson, Kate Smith-Jackson, Beth G. Gibson, Beth G. Gibson, Muhammad Asif, Muhammad Asif, Harriet Denton, Harriet Denton, Charlotte Cox, Patrick Walsh, Patrick Walsh, David Kavanagh, David Kavanagh, Kevin J. Marchbank, Kevin J. Marchbank   +20 more
doaj   +2 more sources

Expression of Properdin, the positive regulator of the Complement Alternative Pathway, at the fetal-maternal interface in Preeclampsia [PDF]

Frontiers in Immunology
IntroductionAberrant complement activation can cause damage to newly formed fetal-derived structures and excessive inflammatory response at the feto-maternal interface, contributing to pregnancy-related complications, including preeclampsia (PE), which ...
Hadida Yasmin, Tamali Roy, Chiara Agostinis, Aishwarya Rao, Priyanka Sharma, Miriam Toffoli, Andrea Balduit, Silvia Pegoraro, Samik Bindu, Rajib Prasad, Giuseppe Ricci, Giuseppe Ricci, Manu Vatish, Taruna Madan, Taruna Madan, Roberta Bulla, Uday Kishore   +16 more
doaj   +2 more sources

Differential expression of complement Properdin and Factor H in the placentae and umbilical cords of mothers with Preeclampsia, Gestational Diabetes Mellitus and Recurrent Pregnancy Loss [PDF]

Frontiers in Immunology
BackgroundProperdin and factor H (FH), the two regulatory proteins of the alternative complement pathway, oppose each other to maintain the complement system’s activation.
Tamali Roy, Ananya Das, Nabanita Chatterjee, Shyama Prasad Saha, Rajib Prasad, Taruna Madan, Hadida Yasmin, Uday Kishore   +7 more
doaj   +2 more sources

Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”

Frontiers in Immunology, 2013
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna Kouser, Cordula M Stover, Robert B Sim   +2 more
exaly   +3 more sources

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Frontiers in Immunology, 2020
Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and can
Rosa G M Lammerts, Stefan P Berger, Jacob van den Born   +2 more
exaly   +3 more sources

Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement
Marloes A H M Michels, , Valentina Gracchi   +2 more
exaly   +3 more sources

Alternative Complement Pathway in Carotid Atherosclerosis: Low Plasma Properdin Levels Associate With Long‐Term Cardiovascular Mortality [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in ...
Mieke C. Louwe, Chrysostomi Gialeli, Annika E. Michelsen, Sverre Holm, Andreas Edsfeldt, Karolina Skagen, Tove Lekva, Maria Belland Olsen, Vigdis Bjerkeli, Therese Schjørlien, Kristine Stø, Xiang Yi Kong, Tuva B. Dahl, Per H. Nilsson, Peter Libby, Pål Aukrust, Tom Eirik Mollnes, Thor Ueland, Mona Skjelland, Isabel Gonçalves, Bente Halvorsen   +20 more
doaj   +2 more sources

Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement

Frontiers in Immunology, 2013
Properdin, the only positive regulatory protein of the complement system, acts as both a stabilizer of the alternative pathway convertases and as a selective pattern recognition molecule of certain microorganisms and host cells (i.e.
Claudio Cortes, Gurpanna Saggu, Viviana P Ferreira   +2 more
exaly   +3 more sources

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin [PDF]

Frontiers in Immunology
IntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore, Uday Kishore, Praveen M. Varghese, Chandan Kumar, Susan Idicula-Thomas, Martin Mayora Neto, Anthony G. Tsolaki, Pretty Ponnachan, Pretty Ponnachan, Khaled Masmoudi, Basel Al-Ramadi, Basel Al-Ramadi, Manu Vatish, Taruna Madan, Taruna Madan, Nigel Temperton, Nazar Beirag, Nazar Beirag   +17 more
doaj   +2 more sources

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID. [PDF]

Immunology
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Keat SBK, Khatri P, Ali YM, Arachchilage CH, Demopulos G, Baillie K, Miners KL, Ladell K, Jones SA, Davies HE, Price DA, Zelek WM, Morgan BP, Schwaeble WJ, Lynch NJ.   +14 more
europepmc   +2 more sources