Results 11 to 20 of about 7,301 (203)

Properdin oligomers adopt rigid extended conformations supporting function [PDF]

eLife, 2021
Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis V Pedersen, Martin Nors Pedersen, Sofia MM Mazarakis, Yong Wang, Kresten Lindorff-Larsen, Lise Arleth, Gregers R Andersen   +6 more
doaj   +2 more sources

Prognostic Value of Complement Properdin in Cancer [PDF]

Frontiers in Immunology, 2021
The complement system is readily triggered by the presence of damage-associated molecular patterns on the surface of tumor cells. The complement alternative pathway provides rapid amplification of the molecular stress signal, leading to complement ...
Alessandro Mangogna, Praveen M. Varghese, Praveen M. Varghese, Chiara Agostinis, Salman H. Alrokayan, Haseeb A. Khan, Cordula M. Stover, Beatrice Belmonte, Anna Martorana, Giuseppe Ricci, Giuseppe Ricci, Roberta Bulla, Uday Kishore   +12 more
doaj   +3 more sources

Complement Properdin Determines Disease Activity in MRL/lpr Mice [PDF]

Medicina, 2020
Background and objects: In systemic lupus erythematosus, circulating immune complexes activate complement and, when trapped in renal capillaries, cause glomerulonephritis.
Hasanain Alaridhee, Azzah Alharbi, Zeayd Saeed, Róisín C. Thomas, Cordula M. Stover   +4 more
doaj   +2 more sources

Properdin levels in human sepsis [PDF]

Frontiers in Immunology, 2015
Properdin is a normal serum protein which increases the production of complement activation products by binding to C3b integral to convertase complexes and amplifying their activity at the site of activation.
Cordula M Stover, John eMcDonald, Simon eByrne, David G Lambert, Jonathan eThompson   +4 more
doaj   +2 more sources

A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples. [PDF]

PLoS ONE, 2014
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can promote
Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber   +9 more
doaj   +3 more sources

Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement [PDF]

eLife, 2020
Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades.
Jie Zhang, Lihong Song, Dennis V Pedersen, Anna Li, John D Lambris, Gregers Rom Andersen, Tom Eirik Mollnes, Ying Jie Ma, Peter Garred   +8 more
doaj   +3 more sources

Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells [PDF]

Antioxidants, 2020
The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD).
Nicole Schäfer, Hannah N. Wolf, Anne Enzbrenner, Juliane Schikora, Maria Reichenthaler, Volker Enzmann, Diana Pauly   +6 more
doaj   +3 more sources

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans [PDF]

mBio, 2011
Fungal cell walls are predominantly composed of glucans, mannans, and chitin. Recognition of these glycans by the innate immune system is a critical component of host defenses against the mycoses.
Sarika Agarwal, Charles A. Specht, Haibin Huang, Gary R. Ostroff, Sanjay Ram, Peter A. Rice, Stuart M. Levitz   +6 more
doaj   +2 more sources

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID. [PDF]

Immunology
The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Keat SBK, Khatri P, Ali YM, Arachchilage CH, Demopulos G, Baillie K, Miners KL, Ladell K, Jones SA, Davies HE, Price DA, Zelek WM, Morgan BP, Schwaeble WJ, Lynch NJ.   +14 more
europepmc   +2 more sources

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease. [PDF]

Am J Hematol
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Allali S, Sbeih N, Rignault-Bricard R, Bruce J, Gall ML, Heilbronner C, de Cacqueray N, Angyalosy S, Taylor M, Brice J, de Montalembert M, Bevacqua M, Gautier EF, Hermine O, Maciel TT.   +14 more
europepmc   +2 more sources