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Alternative pathway diagnostics [PDF]
Immunological Reviews, 2023 SummaryUncontrolled alternative pathway activation is the primary driver of several diseases, and it contributes to the pathogenesis of many others. Consequently, diagnostic tests to monitor this arm of the complement system are increasingly important.
Véronique Fremeaux-Bacchi +1 more
exaly +4 more sources
The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation [PDF]
Clinical & Translational Immunology, 2023 Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation.
Esther CW deBoer +14 more
doaj +2 more sources
The alternative complement pathway revisited [PDF]
Journal of Cellular and Molecular Medicine, 2008 Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
M Harboe, Tom Eirik Mollnes
exaly +3 more sources
Thrombotic microangiopathy mediates poor prognosis among lupus nephritis via complement lectin and alternative pathway activation [PDF]
Frontiers in Immunology, 2022 ObjectiveThe pathogenesis of thrombotic microangiopathy (TMA) in lupus nephritis (LN) remains complicated. This study aimed to detect the deposition of complement lectin pathway (LP) and alternative pathway (AP) components in renal tissues, then evaluate
Binshan Zhang, Guolan Xing
doaj +2 more sources
Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement [PDF]
Frontiers in ImmunologyChagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon +6 more
doaj +2 more sources
Alternative patulin pathway unproven [PDF]
International Journal of Food Microbiology, 2018 Letter to the Editor[Excerpt] We read with interest in your journal that Penicillium expansum strains S3, S31 and S87 ( Rharmitt et al., 2016) were considered negative for possession of the isoepoxydon dehydrogenase (idh) gene for patulin (PAT ...
R. Russell M. Paterson +3 more
openaire +5 more sources
Alternative Macroautophagic Pathways [PDF]
International Journal of Cell Biology, 2012 Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which
Juenemann, Katrin, Reits, Eric A.
openaire +4 more sources
The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs
Frontiers in Immunology, 2022 ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj +1 more source
Frontiers in Immunology, 2022 The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1 ...
Kohei Kusakari +8 more
doaj +1 more source
Diverse Clinical Presentations of C3 Dominant Glomerulonephritis
Frontiers in Medicine, 2020 C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna +13 more
doaj +1 more source