Results 1 to 10 of about 4,775,639 (287)

Alternative pathway diagnostics [PDF]

Immunological Reviews, 2023
SummaryUncontrolled alternative pathway activation is the primary driver of several diseases, and it contributes to the pathogenesis of many others. Consequently, diagnostic tests to monitor this arm of the complement system are increasingly important.
Joshua M Thurman
exaly   +4 more sources

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation [PDF]

Clinical & Translational Immunology, 2023
Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation.
Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius   +14 more
doaj   +2 more sources

The alternative complement pathway revisited [PDF]

Journal of Cellular and Molecular Medicine, 2008
Introduction Methods to study and modify the alternative pathway Influence of AP amplification on the effect of specific activation of the other initial pathways Properdin Influence of AP in deficiency states Complement in sepsis Concluding remarks AbstractAlternative pathway amplification plays a major role for the final effect of initial specific ...
Tom Mollnes
exaly   +3 more sources

Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement [PDF]

Frontiers in Immunology
Chagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon, Galia Ramirez-Toloza, Keith L. Wycoff, Sean Ehinger, Jutamas Shaughnessy, Sanjay Ram, Viviana P. Ferreira   +6 more
doaj   +2 more sources

Assessment of the Role of C3(H2O) in the Alternative Pathway

Frontiers in Immunology, 2020
In this study we investigate the hydrolysis of C3 to C3(H2O) and its ability to initiate activation via the alternative pathway (AP) of the complement system.
Karin Fromell, Anna Adler, Amanda Åman, Vivek Anand Manivel, Shan Huang, Claudia Dührkop, Kerstin Sandholm, Kristina N. Ekdahl, Kristina N. Ekdahl, Bo Nilsson   +9 more
doaj   +3 more sources

Complement Alternative Pathway Dominance in Atypical Hemolytic Uremic Syndrome Revealed by Endothelial Bioassays [PDF]

Kidney International Reports
Donata Santarsiero, Sara Gastoldi, Valeria Guaschino, Elena Bresin, Ilaria Pagani, Andrea Pasini, Elena Romano, Ariela Benigni, Giuseppe Remuzzi, Marina Noris, Sistiana Aiello   +10 more
doaj   +2 more sources

Alternative Macroautophagic Pathways [PDF]

International Journal of Cell Biology, 2012
Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles. This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation. Currently, other alternative autophagy pathways have been described, which
Juenemann, Katrin, Reits, Eric A.
openaire   +4 more sources

The Complement System and ANCA Associated Vasculitis in the Era of Anti-Complement Drugs

Frontiers in Immunology, 2022
ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis (AAV) is the condition in which ANCA, as an autoantibody, is associated with the pathogenesis of vasculitis in small blood vessels, mainly in the ear, nose, throat, kidney, lung, and ...
Yasutaka Kimoto, Takahiko Horiuchi
doaj   +1 more source

The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation

Frontiers in Immunology, 2022
The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1 ...
Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Ikuo Wada, Teizo Fujita, Hideharu Sekine   +8 more
doaj   +1 more source

Diverse Clinical Presentations of C3 Dominant Glomerulonephritis

Frontiers in Medicine, 2020
C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna, Ramy M. Hanna, Jean Hou, Huma Hasnain, Farid Arman, Umut Selamet, Umut Selamet, James Wilson, Samuel Olanrewaju, Jonathan E. Zuckerman, Marina Barsoum, Julie M. Yabu, Ira Kurtz, Ira Kurtz   +13 more
doaj   +1 more source