Results 11 to 20 of about 8,673 (216)

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

Frontiers in Immunology, 2019
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi   +6 more
doaj   +1 more source

Noncanonical NF-κB Signaling Upregulation in Inflammatory Bowel Disease Patients is Associated With Loss of Response to Anti-TNF Agents

Frontiers in Pharmacology, 2021
Objectives: Targeting tumor necrosis factor (TNF) with biologic agents, such as infliximab and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel disease (IBD).
Vu Q. Nguyen, Kristin Eden, Kristin Eden, Holly A. Morrison, Megan B. Sammons, Kristin K. Knight, Siena Sorrentino, Rebecca M. Brock, Douglas J. Grider, Irving C. Allen, Irving C. Allen, Irving C. Allen, Dario Sorrentino, Dario Sorrentino   +13 more
doaj   +1 more source

Autophagy takes an alternative pathway [PDF]

Autophagy, 2010
ATG5 and ATG7 are considered as essential molecules for induction of macroautophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagy-mediated protein degradation when subjected to certain stresses.
Shigeomi, Shimizu, Satoko, Arakawa, Yuya, Nishida   +2 more
openaire   +2 more sources

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Frontiers in Cellular and Infection Microbiology, 2019
The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed, Pipsa Hakala, Anirudh K. Singh, Anirudh K. Singh, Helena A. K. Lapatto, Samantha J. King, Samantha J. King, Seppo Meri, T. Sakari Jokiranta, T. Sakari Jokiranta, Karita Haapasalo   +10 more
doaj   +1 more source

Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Frontiers in Pharmacology, 2020
Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk ...
Matteo Stravalaci, Matteo Stravalaci, Francesca Davi, Raffaella Parente, Marco Gobbi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Anthony J. Day, Simon J. Clark, Simon J. Clark, Mario R. Romano, Mario R. Romano, Antonio Inforzato, Antonio Inforzato   +15 more
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An alternative cytokinin biosynthesis pathway [PDF]

Proceedings of the National Academy of Sciences, 2000
Studies of de novo cytokinin biosynthesis in isopentenyltransferase ( ipt )-transformed Arabidopsis thaliana , involving in vivo deuterium labeling and mass spectrometry, showed that the biosynthetic rate of zeatinriboside-5′-monophosphate was
C, Astot, K, Dolezal, A, Nordström, Q, Wang, T, Kunkel, T, Moritz, N H, Chua, G, Sandberg   +7 more
openaire   +2 more sources

Nitrogen deprivation induces cross-tolerance of Poa annua callus to salt stress

Biologia Plantarum, 2016
Alternative respiration pathway (AP) is an important pathway which can be induced by environment stresses in plants. In the present study, we show a new mechanism involving the AP in nitrogen deprivation-induced tolerance of Poa annua callus to salt ...
C. Z. Zhao, P. Li, X. M. Wang, P. Li, X. Y. Wang, F. Wang, J. F. Wang, N. Chang, Y. R. Bi   +8 more
doaj   +1 more source

Role of complement activation in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

Frontiers in Medicine, 2022
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by necrotizing inflammation of small or medium vessels, causing ANCA associated glomerulonephritis (AAGN).
Tadasu Kojima, Takashi Oda
doaj   +1 more source

An alternative pathway for alphavirus entry [PDF]

Virology Journal, 2011
Abstract The study of alphavirus entry has been complicated by an inability to clearly identify a receptor and by experiments which only tangentially and indirectly examine the process, producing results that are difficult to interpret. The mechanism of entry has been widely accepted to be by endocytosis followed by acidification of the ...
Brown Dennis T, Hernandez Raquel, Kononchik Joseph P   +2 more
openaire   +3 more sources

Alternative Pathway Is Involved in Hydrogen Peroxide-Enhanced Cadmium Tolerance in Hulless Barley Roots

Plants, 2021
Hulless barley, grown in the Qinghai Tibet Plateau, has a wide range of environmental stress tolerance. Alternative pathway (AP) and hydrogen peroxide (H2O2) are involved in enhancing plant tolerance to environmental stresses.
Li He, Xiaomin Wang, Xiaofan Na, Ruijun Feng, Qiang He, Shengwang Wang, Cuifang Liang, Lili Yan, Libin Zhou, Yurong Bi   +9 more
doaj   +1 more source