Results 21 to 30 of about 4,775,639 (287)

Autophagy takes an alternative pathway [PDF]

Autophagy, 2010
ATG5 and ATG7 are considered as essential molecules for induction of macroautophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagy-mediated protein degradation when subjected to certain stresses.
Shigeomi, Shimizu, Satoko, Arakawa, Yuya, Nishida   +2 more
openaire   +2 more sources

Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Frontiers in Pharmacology, 2020
Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk ...
Matteo Stravalaci, Matteo Stravalaci, Francesca Davi, Raffaella Parente, Marco Gobbi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Anthony J. Day, Simon J. Clark, Simon J. Clark, Mario R. Romano, Mario R. Romano, Antonio Inforzato, Antonio Inforzato   +15 more
doaj   +1 more source

Nitrogen deprivation induces cross-tolerance of Poa annua callus to salt stress

Biologia Plantarum, 2016
Alternative respiration pathway (AP) is an important pathway which can be induced by environment stresses in plants. In the present study, we show a new mechanism involving the AP in nitrogen deprivation-induced tolerance of Poa annua callus to salt ...
C. Z. Zhao, P. Li, X. M. Wang, P. Li, X. Y. Wang, F. Wang, J. F. Wang, N. Chang, Y. R. Bi   +8 more
doaj   +1 more source

Role of complement activation in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

Frontiers in Medicine, 2022
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by necrotizing inflammation of small or medium vessels, causing ANCA associated glomerulonephritis (AAGN).
Tadasu Kojima, Takashi Oda
doaj   +1 more source

Alternative Pathway Is Involved in Hydrogen Peroxide-Enhanced Cadmium Tolerance in Hulless Barley Roots

Plants, 2021
Hulless barley, grown in the Qinghai Tibet Plateau, has a wide range of environmental stress tolerance. Alternative pathway (AP) and hydrogen peroxide (H2O2) are involved in enhancing plant tolerance to environmental stresses.
Li He, Xiaomin Wang, Xiaofan Na, Ruijun Feng, Qiang He, Shengwang Wang, Cuifang Liang, Lili Yan, Libin Zhou, Yurong Bi   +9 more
doaj   +1 more source

Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy

Kidney International Reports
Introduction: IgA nephropathy's (IgAN’s) MEST-C classification relationship with complement activation is still not fully understood because of limited and conflicting evidence.
Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard   +3 more
doaj   +1 more source

Modeling complement activation on human glomerular microvascular endothelial cells

Frontiers in Immunology, 2023
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium.
Kes H. Stevens, Laura M. Baas, Thea J. A. M. van der Velden, Romy N. Bouwmeester, Niels van Dillen, Eiske M. Dorresteijn, Arjan D. van Zuilen, Jack F. M. Wetzels, Marloes A. H. M. Michels, Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel   +14 more
doaj   +1 more source

A novel assay that characterizes properdin function shows neutrophil-derived properdin has a distinct oligomeric distribution

Frontiers in Immunology, 2023
Properdin acts as an essential positive regulator of the alternative pathway of complement by stabilizing enzymatic convertases. Identical properdin monomers form head-to-tail associations of oligomers in a reported 20:54:26 ratio (most often described ...
Sara R. Moore, Smrithi S. Menon, Neeti S. Galwankar, Sadik A. Khuder, Michael K. Pangburn, Viviana P. Ferreira   +5 more
doaj   +1 more source

Alternative Exon 9-Encoded Relay Domains Affect More than One Communication Pathway in the Drosophila Myosin Head [PDF]

, 2009
We investigated the biochemical and biophysical properties of one of the four alternative regions within the Drosophila myosin catalytic domain: the relay domain encoded by exon 9.
Girish C. Melkani, Bernstein, Sanford I., Corey M. Dambacher, Geeves, M., Melkani, Girish C., Knowles, Aileen F., Geeves, Michael A., Marieke J. Bloemink, Aileen F. Knowles, Melanki, G., Bloemink, Marieke J., Bloemink, M., Bernstein, S., Sanford I. Bernstein, Dambacher, C., Knowles, A., Dambacher, Corey M., Michael A. Geeves   +17 more
core   +1 more source

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos, Nicholas M. Pearce, Joke Granneman, T. Harma C. Brondijk, Piet Gros   +4 more
doaj   +1 more source