Results 21 to 30 of about 1,708,556 (305)

Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms [PDF]

, 2006
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. Three of them, Asp, Glu, and (oxidized) Cys, function through their conjugation to Arg, one of destabilizing N-terminal residues that are recognized directly by
Brower, Christopher S., Davydov, Ilia V., Hu, Rong-Gui, Kwon, Yong Tae, Sheng, Jun, Varshavsky, Alexander, Wang, Haiqing, Zhou, Jianmin   +7 more
core   +2 more sources

Searching for pathways involving dressed states in optimal control theory [PDF]

, 2011
Selective population of dressed states has been proposed as an alternative control pathway in molecular reaction dynamics [Wollenhaupt et al., J. Photochem. Photobiol. A: Chem., 2006, 180, 248].
Bergmann, Brixner, de Vivie-Riedle, Gaubatz, Geppert, Gollub, Hartmann, Kling, Kosloff, Krausz, Manz, Markus Kowalewski, Netz, Palao, Philipp von den Hoff, Rabitz, Regina de Vivie-Riedle, Sleva, Somloi, Sundermann, Sussman, Tannor, Tesch, Tesch, von den Hoff, von den Hoff, Wollenhaupt, Wollenhaupt, Wollenhaupt, Wollenhaupt, Wollenhaupt, Zhu, Zhu, Znakovskaya   +33 more
core   +1 more source

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

Frontiers in Immunology, 2019
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi   +6 more
doaj   +1 more source

Noncanonical NF-κB Signaling Upregulation in Inflammatory Bowel Disease Patients is Associated With Loss of Response to Anti-TNF Agents

Frontiers in Pharmacology, 2021
Objectives: Targeting tumor necrosis factor (TNF) with biologic agents, such as infliximab and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel disease (IBD).
Vu Q. Nguyen, Kristin Eden, Kristin Eden, Holly A. Morrison, Megan B. Sammons, Kristin K. Knight, Siena Sorrentino, Rebecca M. Brock, Douglas J. Grider, Irving C. Allen, Irving C. Allen, Irving C. Allen, Dario Sorrentino, Dario Sorrentino   +13 more
doaj   +1 more source

Autophagy takes an alternative pathway [PDF]

Autophagy, 2010
ATG5 and ATG7 are considered as essential molecules for induction of macroautophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagy-mediated protein degradation when subjected to certain stresses.
Shigeomi, Shimizu, Satoko, Arakawa, Yuya, Nishida   +2 more
openaire   +2 more sources

Isoprene oxidation by the gram-negative model bacterium variovorax sp. WS11 [PDF]

, 2020
Plant-produced isoprene (2-methyl-1,3-butadiene) represents a significant portion of global volatile organic compound production, equaled only by methane.
Crombie, Andrew T., Dawson, Robin A., Larke-Mejía, Nasmille L., Murrell, J. Colin, Ul Haque, Muhammad Farhan   +4 more
core   +1 more source

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Frontiers in Cellular and Infection Microbiology, 2019
The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed, Pipsa Hakala, Anirudh K. Singh, Anirudh K. Singh, Helena A. K. Lapatto, Samantha J. King, Samantha J. King, Seppo Meri, T. Sakari Jokiranta, T. Sakari Jokiranta, Karita Haapasalo   +10 more
doaj   +1 more source

Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency : an alternative pathway [PDF]

, 2012
Objective To determine the ability of selective antibody testing to screen for coeliac disease in the presence of IgA deficiency and to define the sensitivity of a pathway using this method (Figure1).
Arasaradnam, Ramesh P., Harrison, Elizabeth, Liu, Kuo-Kang, Loft, Duncan, Nwokolo, Chuka U., Petchey, Michael   +5 more
core   +1 more source

Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Frontiers in Pharmacology, 2020
Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk ...
Matteo Stravalaci, Matteo Stravalaci, Francesca Davi, Raffaella Parente, Marco Gobbi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Anthony J. Day, Simon J. Clark, Simon J. Clark, Mario R. Romano, Mario R. Romano, Antonio Inforzato, Antonio Inforzato   +15 more
doaj   +1 more source

An alternative cytokinin biosynthesis pathway [PDF]

Proceedings of the National Academy of Sciences, 2000
Studies of de novo cytokinin biosynthesis in isopentenyltransferase ( ipt )-transformed Arabidopsis thaliana , involving in vivo deuterium labeling and mass spectrometry, showed that the biosynthetic rate of zeatinriboside-5′-monophosphate was
C, Astot, K, Dolezal, A, Nordström, Q, Wang, T, Kunkel, T, Moritz, N H, Chua, G, Sandberg   +7 more
openaire   +2 more sources