Results 21 to 30 of about 1,689,260 (355)

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Isoprene oxidation by the gram-negative model bacterium variovorax sp. WS11 [PDF]

, 2020
Plant-produced isoprene (2-methyl-1,3-butadiene) represents a significant portion of global volatile organic compound production, equaled only by methane.
Crombie, Andrew T., Dawson, Robin A., Larke-Mejía, Nasmille L., Murrell, J. Colin, Ul Haque, Muhammad Farhan   +4 more
core   +1 more source

Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus

Frontiers in Immunology, 2019
Bacterial infections are frequent and severe in patients with diabetes mellitus. Whether diabetes per se induces functional alterations in the complement system hampering activation during infection is unknown.
László József Barkai, Emese Sipter, Dorottya Csuka, Zoltán Prohászka, Katrine Pilely, Peter Garred, Nóra Hosszúfalusi   +6 more
doaj   +1 more source

Noncanonical NF-κB Signaling Upregulation in Inflammatory Bowel Disease Patients is Associated With Loss of Response to Anti-TNF Agents

Frontiers in Pharmacology, 2021
Objectives: Targeting tumor necrosis factor (TNF) with biologic agents, such as infliximab and adalimumab, is a widely used and effective therapeutic strategy in inflammatory bowel disease (IBD).
Vu Q. Nguyen, Kristin Eden, Kristin Eden, Holly A. Morrison, Megan B. Sammons, Kristin K. Knight, Siena Sorrentino, Rebecca M. Brock, Douglas J. Grider, Irving C. Allen, Irving C. Allen, Irving C. Allen, Dario Sorrentino, Dario Sorrentino   +13 more
doaj   +1 more source

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Frontiers in Cellular and Infection Microbiology, 2019
The most frequent form of hemolytic-uremic syndrome (HUS) is associated with infections caused by Shiga-like toxin-producing Enterohaemorrhagic Escherichia coli (STEC). In rarer cases HUS can be triggered by Streptococcus pneumoniae.
Shahan Syed, Pipsa Hakala, Anirudh K. Singh, Anirudh K. Singh, Helena A. K. Lapatto, Samantha J. King, Samantha J. King, Seppo Meri, T. Sakari Jokiranta, T. Sakari Jokiranta, Karita Haapasalo   +10 more
doaj   +1 more source

Control of Complement Activation by the Long Pentraxin PTX3: Implications in Age-Related Macular Degeneration

Frontiers in Pharmacology, 2020
Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk ...
Matteo Stravalaci, Matteo Stravalaci, Francesca Davi, Raffaella Parente, Marco Gobbi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani, Anthony J. Day, Simon J. Clark, Simon J. Clark, Mario R. Romano, Mario R. Romano, Antonio Inforzato, Antonio Inforzato   +15 more
doaj   +1 more source

Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency : an alternative pathway [PDF]

, 2012
Objective To determine the ability of selective antibody testing to screen for coeliac disease in the presence of IgA deficiency and to define the sensitivity of a pathway using this method (Figure1).
Arasaradnam, Ramesh P., Harrison, Elizabeth, Liu, Kuo-Kang, Loft, Duncan, Nwokolo, Chuka U., Petchey, Michael   +5 more
core   +1 more source

Role of complement activation in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

Frontiers in Medicine, 2022
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease characterized by necrotizing inflammation of small or medium vessels, causing ANCA associated glomerulonephritis (AAGN).
Tadasu Kojima, Takashi Oda
doaj   +1 more source

An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 Expression [PDF]

, 2009
SummaryDiffuse large B cell lymphoma (DLBCL) is a complex disease comprising diverse subtypes and genetic profiles. Possibly because of the prevalence of genetic alterations activating canonical NF-κB activity, a role for oncogenic lesions that activate ...
Alizadeh, Annunziata, Basso, Bidère, Brown, Calado, Casola, Cattoretti, Choi, Compagno, Davis, Davis, Fabre, Gardam, Grumont, Häcker, Hans, He, Iqbal, Kato, Keats, Klein, Lenz, Lenz, Mandelbaum, Martins, Monti, Moore, Morin, Neri, Ngo, O’Mahony, Ohinata, Pasqualucci, Pasqualucci, Pham, Rossi, Saito, Sasaki, Sasaki, Sciammas, Shaffer, Srinivas, Staudt, Tam, Traenckner, Tunyaplin, Wright, Ye   +48 more
core   +3 more sources

Nitrogen deprivation induces cross-tolerance of Poa annua callus to salt stress

Biologia Plantarum, 2016
Alternative respiration pathway (AP) is an important pathway which can be induced by environment stresses in plants. In the present study, we show a new mechanism involving the AP in nitrogen deprivation-induced tolerance of Poa annua callus to salt ...
C. Z. Zhao, P. Li, X. M. Wang, P. Li, X. Y. Wang, F. Wang, J. F. Wang, N. Chang, Y. R. Bi   +8 more
doaj   +1 more source