Results 1 to 10 of about 1,260,166 (238)

Mannose-binding lectin 2 gene and risk of adult glioma. [PDF]

PLoS ONE, 2013
The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers.To examine the role ...
Dominique S Michaud, Afshan Siddiq, David G Cox, Danielle M Backes, Federico C F Calboli, Michael E Sughrue, J Michael Gaziano, Jing Ma, Meir Stampfer, Shelley S Tworoger, David J Hunter, Carlos A Camargo, Andrew T Parsa   +12 more
doaj   +1 more source

The Lectin Pathway of Complement in Myocardial Ischemia/Reperfusion Injury—Review of Its Significance and the Potential Impact of Therapeutic Interference by C1 Esterase Inhibitor

Frontiers in Immunology, 2018
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in modern medicine. Early reperfusion accomplished by primary percutaneous coronary intervention is pivotal for reducing myocardial damage in ST elevation AMI.
Anneza Panagiotou, Marten Trendelenburg, Marten Trendelenburg, Michael Osthoff, Michael Osthoff   +4 more
doaj   +1 more source

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.

PLoS Pathogens, 2022
The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo, Heather L Jewhurst, József Dobó, Péter Gál, John P Dalton, Krystyna Cwiklinski   +5 more
doaj   +1 more source

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +1 more source

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus

Frontiers in Immunology, 2016
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred   +5 more
doaj   +1 more source

Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults

Immunity & Ageing, 2020
Background There is increasing recognition of the significance of chronic, low-level inflammation in older adults, or “inflammaging.” Innate immune responses and host-bacterial interactions are recognized as key factors in inflammaging.
David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield, Moon H. Nahm   +4 more
doaj   +1 more source

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway. [PDF]

PLoS Neglected Tropical Diseases, 2014
Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the World Health Organisation.
Simone L Reynolds, Robert N Pike, Angela Mika, Anna M Blom, Andreas Hofmann, Lakshmi C Wijeyewickrema, Dave Kemp, Katja Fischer   +7 more
doaj   +1 more source

The Complement System of Agnathans

Frontiers in Immunology, 2018
Agnathans (lamprey and hagfish) are a group of primitive jawless fish. Jawed vertebrates possess adaptive immunity including immunoglobulins, while agnathans lack immunoglobulins but have alternative adaptive immunity in which variable lymphocyte ...
Misao Matsushita
doaj   +1 more source

Isolation and characterization of novel primary cells from the human distal outflow pathway

Scientific Reports, 2021
Ocular hypertension occurs due to increased resistance to aqueous humor removal through the conventional outflow pathway. Unlike the proximal region of the conventional outflow pathway, the distal region has not been well studied, mostly due to lack of ...
Uttio Roy Chowdhury, Cindy K. Bahler, Cheryl R. Hann, Bradley H. Holman, Michael P. Fautsch   +4 more
doaj   +1 more source

Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum.

PLoS Pathogens, 2019
Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 ...
Zoltán Attila Nagy, Dávid Szakács, Eszter Boros, Dávid Héja, Eszter Vígh, Noémi Sándor, Mihály Józsi, Gábor Oroszlán, József Dobó, Péter Gál, Gábor Pál   +10 more
doaj   +1 more source