Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway–mediated disorders [PDF]
Frontiers in Immunology, 2023 IntroductionOveractivation of the lectin pathway of complement plays a pathogenic role in a broad range of immune-mediated and inflammatory disorders; mannan-binding lectin-associated serine protease-2 (MASP-2) is the key effector enzyme of the lectin ...
Thomas Dudler +2 more
doaj +2 more sources
Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice [PDF]
Frontiers in Immunology, 2023 Acute respiratory distress syndrome (ARDS) is a life-threatening disorder with a high rate of mortality. Complement activation in ARDS initiates a robust inflammatory reaction that can cause progressive endothelial injury in the lung.
Youssif M. Ali +11 more
doaj +2 more sources
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups [PDF]
Frontiers in Immunology, 2023 IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus.
Lisa Hurler +174 more
doaj +2 more sources
Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus [PDF]
Heliyon, 2023 In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE.
Yuko Asanuma +6 more
doaj +2 more sources
Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease [PDF]
Frontiers in Immunology, 2021 We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a key contributor to innate immunity and inflammation.
Nicholas R. Medjeral-Thomas +23 more
doaj +2 more sources
Dengue and the Lectin Pathway of the Complement System. [PDF]
Viruses, 2021 Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4). Usually, the primary infection is asymptomatic or causes mild dengue fever (DF), while secondary infections with a different serotype increase the risk of severe dengue disease (dengue ...
Kraivong R +4 more
europepmc +6 more sources
Lectin complement pathway proteins in healthy individuals [PDF]
Clinical and Experimental Immunology, 2017 Summary Since the discovery of the lectin pathway of complement activation, numerous clinical cohorts have been examined for one or more proteins, with the intention of uncovering the functions of the proteins or with the aim of discovering new biomarkers or diagnostic tools. To unveil the abnormal, it is pivotal to know the normal.
Steffen Thiel +2 more
exaly +5 more sources
The Lectin Pathway of Complement and Rheumatic Heart Disease [PDF]
Frontiers in Pediatrics, 2015 The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame +4 more
doaj +3 more sources
Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity [PDF]
Lupus Science and MedicineObjective SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the contribution of the lectin pathway remains unclear.
Elisabet Svenungsson +13 more
doaj +2 more sources