Results 1 to 10 of about 3,085,926 (188)
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. [PDF]
PLoS Pathogens, 2012 The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali +15 more
doaj +10 more sources
Frontiers in Immunology, 2023 Acute respiratory distress syndrome (ARDS) is a life-threatening disorder with a high rate of mortality. Complement activation in ARDS initiates a robust inflammatory reaction that can cause progressive endothelial injury in the lung.
Youssif M. Ali +11 more
doaj +2 more sources
Frontiers in Immunology, 2023 IntroductionOveractivation of the lectin pathway of complement plays a pathogenic role in a broad range of immune-mediated and inflammatory disorders; mannan-binding lectin-associated serine protease-2 (MASP-2) is the key effector enzyme of the lectin ...
Thomas Dudler +2 more
doaj +2 more sources
Dengue and the Lectin Pathway of the Complement System [PDF]
Viruses, 2021 Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4).
R. Kraivong +4 more
semanticscholar +5 more sources
Frontiers in Immunology, 2023 IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus.
Lisa Hurler +174 more
doaj +2 more sources
Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease
Frontiers in Immunology, 2021 We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a key contributor to innate immunity and inflammation.
Nicholas R. Medjeral-Thomas +23 more
doaj +2 more sources
Components of the Lectin Pathway of Complement in Haematologic Malignancies [PDF]
Cancers, 2020 The complement system is activated cascadically via three distinct major routes: classical pathway (CP), alternative pathway (AP) or lectin pathway (LP).
M. Cedzyński, A. Świerzko
semanticscholar +3 more sources
IgA Nephropathy: the Lectin Pathway and Implications for Targeted Therapy.
Kidney International, 2023 Many patients with IgA nephropathy (IgAN) progress to end-stage kidney disease even with optimal supportive care. An improved understanding of the pathophysiology of IgAN in recent years has led to the investigation of targeted therapies with acceptable ...
J. Barratt +7 more
semanticscholar +4 more sources
Frontiers in Immunology, 2018 Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in modern medicine. Early reperfusion accomplished by primary percutaneous coronary intervention is pivotal for reducing myocardial damage in ST elevation AMI.
Anneza Panagiotou +4 more
doaj +2 more sources
Experimental Hematology & Oncology, 2021 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki +6 more
doaj +2 more sources