Components of the Lectin Pathway of Complement in Solid Tumour Cancers [PDF]
Cancers (Basel), 2022 Simple Summary Cancer is a major cause of human deaths. The complement system is an important branch of the innate immune response that can be activated via three distinct pathways (classical, alternative, lectin). Complement activation may contribute to
M. Cedzyński, A. Świerzko
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Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus [PDF]
Heliyon, 2023 In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE.
Yuko Asanuma +6 more
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Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins [PDF]
Front Immunol, 2021 Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe ...
Youssif M. Ali +8 more
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Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality [PDF]
Front Immunol, 2021 Background The SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
F. Defendi +15 more
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Lectin complement pathway proteins in healthy individuals [PDF]
Clinical and Experimental Immunology, 2017 Summary Since the discovery of the lectin pathway of complement activation, numerous clinical cohorts have been examined for one or more proteins, with the intention of uncovering the functions of the proteins or with the aim of discovering new biomarkers or diagnostic tools. To unveil the abnormal, it is pivotal to know the normal.
Anne Troldborg +2 more
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Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression [PDF]
Nat Cancer, 2021 Complement has emerged as a component of tumor-promoting inflammation. We conducted a systematic assessment of the role of complement activation and effector pathways in sarcomas.
Elena Magrini +19 more
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Frontiers in Immunology, 2020 The lectin pathway of the complement system is one of the main components of innate immunity, which plays a pivotal role in the defense against infectious microorganisms and maintains immune homeostasis.
Liangliang Mu +5 more
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The Lectin Pathway of the Complement System—Activation, Regulation, Disease Connections and Interplay with Other (Proteolytic) Systems [PDF]
Int J Mol SciThe complement system is the other major proteolytic cascade in the blood of vertebrates besides the coagulation–fibrinolytic system. Among the three main activation routes of complement, the lectin pathway (LP) has been discovered the latest, and it is ...
J. Dobó +5 more
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The Lectin Pathway of Complement and Rheumatic Heart Disease [PDF]
Frontiers in Pediatrics, 2015 The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame +4 more
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