Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway–mediated disorders [PDF]
Frontiers in Immunology, 2023 IntroductionOveractivation of the lectin pathway of complement plays a pathogenic role in a broad range of immune-mediated and inflammatory disorders; mannan-binding lectin-associated serine protease-2 (MASP-2) is the key effector enzyme of the lectin ...
Thomas Dudler +2 more
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Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice [PDF]
Frontiers in Immunology, 2023 Acute respiratory distress syndrome (ARDS) is a life-threatening disorder with a high rate of mortality. Complement activation in ARDS initiates a robust inflammatory reaction that can cause progressive endothelial injury in the lung.
Youssif M. Ali +11 more
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Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups [PDF]
Frontiers in Immunology, 2023 IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus.
Lisa Hurler +174 more
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Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus [PDF]
Heliyon, 2023 In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE.
Yuko Asanuma +6 more
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Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease [PDF]
Frontiers in Immunology, 2021 We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a key contributor to innate immunity and inflammation.
Nicholas R. Medjeral-Thomas +23 more
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Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity [PDF]
Lupus Science and MedicineObjective SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the contribution of the lectin pathway remains unclear.
Elisabet Svenungsson +13 more
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Revisiting the interaction between complement lectin pathway protease MASP-2 and SARS-CoV-2 nucleoprotein [PDF]
Frontiers in ImmunologyComplement activation is considered to contribute to the pathogenesis of severe SARS-CoV-2 infection, mainly by generating potent immune effector mechanisms including a strong inflammatory response.
Isabelle Bally +15 more
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The Lectin Pathway of Complement and Rheumatic Heart Disease
Frontiers in Pediatrics, 2015 The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame +4 more
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Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy [PDF]
Experimental Hematology & Oncology, 2021 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki +6 more
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Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels. [PDF]
PLoS Neglected Tropical Diseases, 2020 BackgroundDeposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement.
Hellen Weinschutz Mendes +5 more
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