Components of the Lectin Pathway of Complement in Haematologic Malignancies. [PDF]
Cancers (Basel), 2020 The complement system is activated cascadically via three distinct major routes: classical pathway (CP), alternative pathway (AP) or lectin pathway (LP). The unique factors associated with the latter are collectins (mannose-binding lectin, collectin-10, collectin-11), ficolins (ficolin-1, ficolin-2, ficolin-3) and proteins of the mannose-binding lectin-
Cedzyński M, Świerzko AS.
europepmc +4 more sources
Revisiting the interaction between complement lectin pathway protease MASP-2 and SARS-CoV-2 nucleoprotein [PDF]
Frontiers in ImmunologyComplement activation is considered to contribute to the pathogenesis of severe SARS-CoV-2 infection, mainly by generating potent immune effector mechanisms including a strong inflammatory response.
Isabelle Bally +15 more
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Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy [PDF]
Experimental Hematology & Oncology, 2021 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki +6 more
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Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels. [PDF]
PLoS Neglected Tropical Diseases, 2020 BackgroundDeposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement.
Hellen Weinschutz Mendes +5 more
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Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo
Immunobiology, 2006 Recent evidence has implicated a role for the MBL‐dependent lectin pathway in gastrointestinal ischemia/reperfusion (I/R)‐induced injury. However, previous studies have implicated IgM and the classical pathway as initiators of complement activation following I/R.
Melanie Hart, Gregory Stahl
exaly +3 more sources
Lectin complement pathway and diabetes mellitus in the pathogenesis of membranous nephropathy [PDF]
Folia Medica, 2023 Introduction: Membranous nephropathy (MN) is a glomerulonephritis with growing incidence and its pathogenesis still remains unclear, despite discoveries of many new antigens.
Irina Y. Zdravkova +2 more
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Mitochondria and the Lectin Pathway of Complement [PDF]
Journal of Biological Chemistry, 2013 Mitochondria, the powerhouses of our cells, are remnants of a eubacterial endosymbiont. Notwithstanding the evolutionary time that has passed since the initial endosymbiotic event, mitochondria have retained many hallmarks of their eubacterial origin. Recent studies have indicated that during perturbations of normal homeostasis, such as following acute
Brinkmann, Christel R +8 more
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Lectins and traffic in the secretory pathway [PDF]
FEBS Letters, 2000 Evidence is accumulating that intracellular animal lectins play important roles in quality control and glycoprotein sorting along the secretory pathway. Calnexin and calreticulin in conjunction with associated chaperones promote correct folding and oligomerization of many glycoproteins in the endoplasmic reticulum (ER).
Hauri, H. +3 more
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Инфекция и иммунитет, 2022 The complement system is the most ancient components in the innate immunity, mainly functioning to primarily eliminate bacterial agents intravascularly.
Marina V. Smolnikova +1 more
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Mannose binding lectin defects and autoimmune diseases [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2022 Complement system has a very important role in our defense against different pathogens and harmful immune complexes. The lectin pathway of complement system is activated by mannose binding lectin leading to complement cascade ending with the removal of ...
Marwa Azab +5 more
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