Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab [PDF]
Immunobiology, 2020 In COVID-19, acute respiratory distress syndrome (ARDS) and thrombotic events are frequent, life-threatening complications. Autopsies commonly show arterial thrombosis and severe endothelial damage. Endothelial damage, which can play an early and central
A. Rambaldi +16 more
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The Lectin Pathway in Thrombotic Conditions—A Systematic Review [PDF]
Thrombosis and Haemostasis, 2018 The lectin pathway of the complement system can activate the coagulation system in vitro, but the role of the lectin pathway in haemostatic activation and thrombosis in vivo is not clear.
J. Larsen, C. Hvas, A. Hvas
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The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System [PDF]
Front Immunol, 2020 Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the
A. Świerzko, M. Cedzyński
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The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury [PDF]
Transl Res, 2020 Although some evidence showed the activation of complement systems in COVID-19 patients, proinflammatory status and lectin pathway remain unclear.
Mineia Alessandra Scaranello Malaquias +13 more
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Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity [PDF]
Lupus Science and MedicineObjective SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the contribution of the lectin pathway remains unclear.
Elisabet Svenungsson +13 more
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Revisiting the interaction between complement lectin pathway protease MASP-2 and SARS-CoV-2 nucleoprotein [PDF]
Frontiers in ImmunologyComplement activation is considered to contribute to the pathogenesis of severe SARS-CoV-2 infection, mainly by generating potent immune effector mechanisms including a strong inflammatory response.
Isabelle Bally +15 more
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Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway [PDF]
J Clin Immunol, 2019 Mannose-binding lectin (MBL)-associated serine protease-2 (MASP-2) is an indispensable enzyme for the activation of the lectin pathway of complement. Its deficiency is classified as a primary immunodeficiency associated to pyogenic bacterial infections ...
M. I. García-Laorden +16 more
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Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels. [PDF]
PLoS Neglected Tropical Diseases, 2020 BackgroundDeposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement.
Hellen Weinschutz Mendes +5 more
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Lectin complement pathway and diabetes mellitus in the pathogenesis of membranous nephropathy [PDF]
Folia Medica, 2023 Introduction: Membranous nephropathy (MN) is a glomerulonephritis with growing incidence and its pathogenesis still remains unclear, despite discoveries of many new antigens.
Irina Y. Zdravkova +2 more
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Mitochondria and the Lectin Pathway of Complement [PDF]
Journal of Biological Chemistry, 2013 Mitochondria, the powerhouses of our cells, are remnants of a eubacterial endosymbiont. Notwithstanding the evolutionary time that has passed since the initial endosymbiotic event, mitochondria have retained many hallmarks of their eubacterial origin. Recent studies have indicated that during perturbations of normal homeostasis, such as following acute
Brinkmann, Christel R +8 more
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