Results 21 to 30 of about 107,224 (249)

Use of C4d as a diagnostic tool to classify membranoproliferative glomerulonephritis

Nefrología (English Edition), 2017
Background: Membranoproliferative glomerulonephritis (MPGN type I, II and III) was reclassified in 2013 as MPGN and C3 glomerulopathy (C3G) based on the complement system activation mechanism.
Nirupama Gupta, Dara N. Wakefield, William L. Clapp, Eduardo H. Garin   +3 more
doaj   +3 more sources

Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides

Acta Pharmaceutica Sinica B, 2015
Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall ...
Mulu Wu, Hong Li, Yunyi Zhang, Daofeng Chen   +3 more
doaj   +1 more source

Mannose-binding lectin 2 gene and risk of adult glioma. [PDF]

PLoS ONE, 2013
The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers.To examine the role ...
Dominique S Michaud, Afshan Siddiq, David G Cox, Danielle M Backes, Federico C F Calboli, Michael E Sughrue, J Michael Gaziano, Jing Ma, Meir Stampfer, Shelley S Tworoger, David J Hunter, Carlos A Camargo, Andrew T Parsa   +12 more
doaj   +1 more source

The Lectin Pathway of Complement in Myocardial Ischemia/Reperfusion Injury—Review of Its Significance and the Potential Impact of Therapeutic Interference by C1 Esterase Inhibitor

Frontiers in Immunology, 2018
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in modern medicine. Early reperfusion accomplished by primary percutaneous coronary intervention is pivotal for reducing myocardial damage in ST elevation AMI.
Anneza Panagiotou, Marten Trendelenburg, Marten Trendelenburg, Michael Osthoff, Michael Osthoff   +4 more
doaj   +1 more source

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.

PLoS Pathogens, 2022
The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo, Heather L Jewhurst, József Dobó, Péter Gál, John P Dalton, Krystyna Cwiklinski   +5 more
doaj   +1 more source

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

PLoS Pathogens, 2012
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Youssif M Ali, Nicholas J Lynch, Kashif S Haleem, Teizo Fujita, Yuichi Endo, Soren Hansen, Uffe Holmskov, Kazue Takahashi, Gregory L Stahl, Thomas Dudler, Umakhanth V Girija, Russell Wallis, Aras Kadioglu, Cordula M Stover, Peter W Andrew, Wilhelm J Schwaeble   +15 more
doaj   +1 more source

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus

Frontiers in Immunology, 2016
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred   +5 more
doaj   +1 more source

Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults

Immunity & Ageing, 2020
Background There is increasing recognition of the significance of chronic, low-level inflammation in older adults, or “inflammaging.” Innate immune responses and host-bacterial interactions are recognized as key factors in inflammaging.
David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield, Moon H. Nahm   +4 more
doaj   +1 more source

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway. [PDF]

PLoS Neglected Tropical Diseases, 2014
Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the World Health Organisation.
Simone L Reynolds, Robert N Pike, Angela Mika, Anna M Blom, Andreas Hofmann, Lakshmi C Wijeyewickrema, Dave Kemp, Katja Fischer   +7 more
doaj   +1 more source

Enhancement of lectin pathway haemolysis by immunoglobulins

Clinical and Experimental Immunology, 1999
SUMMARYWe recently reported that indicator sheep erythrocytes (E) coated with mannan and sensitized with mannan-binding lectin (MBL) (E-M-MBL) are lysed by human serum in the absence of calcium via the lectin pathway of complement activation by a process which requires alternative pathway amplification and is associated with increased binding of and ...
C, Suankratay, Y, Zhang, D, Jones, T F, Lint, H, Gewurz   +4 more
openaire   +3 more sources