Results 1 to 10 of about 11,460 (178)

Identification of novel blood-borne soluble binding partners of factor H-related proteins [PDF]

Scientific Reports
The deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases.
Jiaqi Tang, Franziska Woerz, Tina Beyer, Karsten Boldt, Sonika Rathi, Shiying Zhao, Lasse Wolfram, Marius Ueffing, Simon J. Clark   +8 more
doaj   +2 more sources

Mannose binding lectin defects and autoimmune diseases [PDF]

Records of Pharmaceutical & Biomedical Sciences, 2022
Complement system has a very important role in our defense against different pathogens and harmful immune complexes. The lectin pathway of complement system is activated by mannose binding lectin leading to complement cascade ending with the removal of ...
Marwa Azab, Hany Hashem, Emad Eldin Ibrahim, Hoda Abdallah, Ali Abdelrahman, Mohammed Behairy   +5 more
doaj   +1 more source

Proteins of the lectin pathway of the complement system activation: immunobiological functions, genetics and involvement in the pathogenesis of human diseases

Инфекция и иммунитет, 2022
The complement system is the most ancient components in the innate immunity, mainly functioning to primarily eliminate bacterial agents intravascularly.
Marina V. Smolnikova, Sergey Yu. Tereshchenko   +1 more
doaj   +1 more source

Mannose-binding lectin 2 gene and risk of adult glioma. [PDF]

PLoS ONE, 2013
The immune system is likely to play a key role in the etiology of gliomas. Genetic polymorphisms in the mannose-binding lectin gene, a key activator in the lectin complement pathway, have been associated with risk of several cancers.To examine the role ...
Dominique S Michaud, Afshan Siddiq, David G Cox, Danielle M Backes, Federico C F Calboli, Michael E Sughrue, J Michael Gaziano, Jing Ma, Meir Stampfer, Shelley S Tworoger, David J Hunter, Carlos A Camargo, Andrew T Parsa   +12 more
doaj   +1 more source

MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 [PDF]

Genetics and Molecular Biology, 2021
Components of the complement system and atypical parameters of coagulation were reported in COVID-19 patients, as well as the exacerbation of the inflammation and coagulation activity.
Valéria Bumiller-Bini, Camila de Freitas Oliveira-Toré, Tamyres Mingorance Carvalho, Gabriela Canalli Kretzschmar, Letícia Boslooper Gonçalves, Nina de Moura Alencar, Miguel Angelo Gasparetto Filho, Marcia Holsbach Beltrame, Angelica Beate Winter Boldt   +8 more
doaj   +1 more source

Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus

Heliyon, 2023
In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE.
Yuko Asanuma, Kazuhisa Nozawa, Masakazu Matsushita, Makio Kusaoi, Yoshiyuki Abe, Ken Yamaji, Naoto Tamura   +6 more
doaj   +1 more source

MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis

Journal of Innate Immunity, 2021
Activation of the complement system is mediated by the interaction between pathogens and pattern recognition molecules (PRMs); mannose-binding lectin (MBL), ficolins, and collectin-10/-11 from the lectin pathway and C1q from the classical pathway. Lectin
Anne Rosbjerg, Reinhard Würzner, Peter Garred, Mikkel-Ole Skjoedt   +3 more
doaj   +1 more source

Lectin complement pathway and diabetes mellitus in the pathogenesis of membranous nephropathy [PDF]

Folia Medica, 2023
Introduction: Membranous nephropathy (MN) is a glomerulonephritis with growing incidence and its pathogenesis still remains unclear, despite discoveries of many new antigens.
Irina Y. Zdravkova, Eduard E. Tilkiyan, Desislava M. Bozhkova   +2 more
doaj   +3 more sources

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.

PLoS Pathogens, 2022
The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo, Heather L Jewhurst, József Dobó, Péter Gál, John P Dalton, Krystyna Cwiklinski   +5 more
doaj   +1 more source

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway. [PDF]

PLoS Neglected Tropical Diseases, 2014
Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the World Health Organisation.
Simone L Reynolds, Robert N Pike, Angela Mika, Anna M Blom, Andreas Hofmann, Lakshmi C Wijeyewickrema, Dave Kemp, Katja Fischer   +7 more
doaj   +1 more source