Results 31 to 40 of about 11,460 (178)

The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway [PDF]

The Journal of Immunology, 2011
Abstract Mannose-binding lectin (MBL)-associated serine proteases (MASPs) are responsible for activation of the lectin complement pathway. Three types of MASPs (MASP-1, MASP-2, and MASP-3) are complexed with MBL and ficolins in serum.
Daisuke, Iwaki, Kazuko, Kanno, Minoru, Takahashi, Yuichi, Endo, Misao, Matsushita, Teizo, Fujita   +5 more
openaire   +2 more sources

Activity of Mannose-Binding Lectin on Bacterial-Infected Chickens—A Review

Animals, 2021
In recent years, diseases caused by pathogenic bacteria have profoundly impacted chicken production by causing economic loss in chicken products and by-product revenues. MBL (mannose-binding lectin) is part of the innate immune system (IIS), which is the
Peter A. Idowu, Adeola P. Idowu, Oliver T. Zishiri, Takalani J. Mpofu, Edwin J. A. Veldhuizen, Khathutshelo A. Nephawe, Bohani Mtileni   +6 more
doaj   +1 more source

Toxoplasma gondii Recruits Factor H and C4b-Binding Protein to Mediate Resistance to Serum Killing and Promote Parasite Persistence in vivo

Frontiers in Immunology, 2020
Regulating complement is an important step in the establishment of infection by microbial pathogens. Toxoplasma gondii actively resists complement-mediated killing in non-immune human serum (NHS) by inactivating C3b, however the precise molecular basis ...
Patricia M. Sikorski, Patricia M. Sikorski, Alessandra G. Commodaro, Michael E. Grigg   +3 more
doaj   +1 more source

The emerging roles of mannose‐binding lectin‐associated serine proteases (MASPs) in the lectin pathway of complement and beyond [PDF]

Immunological Reviews, 2016
SummaryMannose‐binding lectin (MBL)‐associated serine proteases (MASPs) are the enzymatic constituents of the lectin pathway of the complement system. They are complexed with large pattern recognition molecules (PRMs) such as MBL, other collectins, and ficolins.
Dobó, József, Pál, Gábor, Cervenak, László, Gál, Péter   +3 more
openaire   +3 more sources

Moraxella catarrhalisis only a weak activator of the mannose-binding lectin (MBL) pathway of complement activation [PDF]

FEMS Microbiology Letters, 2005
A hemolytic bystander assay was used to assess the functional serum mannose-binding lectin (MBL) activating capacity of five isolates of Moraxella catarrhalis obtained from children who suffered recurrent acute otitis media episodes. Results showed that this organism is only a poor activator of the lectin pathway of complement activation, with ...
Hays, John, Ott, A, Verduin, CM, Belkum, Alex, Kuipers, S   +4 more
openaire   +3 more sources

Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus

Frontiers in Immunology, 2016
Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg, Ninette Genster, Katrine Pilely, Mikkel-Ole Skjoedt, Gregory L Stahl, Peter Garred   +5 more
doaj   +1 more source

Human Mannose-binding Lectin and l-Ficolin Function as Specific Pattern Recognition Proteins in the Lectin Activation Pathway of Complement [PDF]

Journal of Biological Chemistry, 2004
The innate immune response in vertebrates and invertebrates requires the presence of pattern recognition receptors or proteins that recognize microbial cell components including lipopolysaccharide, bacterial peptidoglycan (PGN), and fungal 1,3-beta-D-glucan.
Young Gerl, Ma, Mi Yhang, Cho, Mingyi, Zhao, Ji Won, Park, Misao, Matsushita, Teizo, Fujita, Bok Luel, Lee   +6 more
openaire   +2 more sources

The Lectin Complement Pathway Is Involved in Protection Against Enteroaggregative Escherichia coli Infection

Frontiers in Immunology, 2018
Enteroaggregative Escherichia coli (EAEC) causes acute and persistent diarrhea worldwide. Still, the involvement of host factors in EAEC infections is unresolved. Binding of recognition molecules from the lectin pathway of complement to EAEC strains have
Camilla Adler Sørensen, Camilla Adler Sørensen, Anne Rosbjerg, Betina Hebbelstrup Jensen, Karen Angeliki Krogfelt, Peter Garred   +5 more
doaj   +1 more source

Functional analysis of Ficolin-3 mediated complement activation.

PLoS ONE, 2010
The recognition molecules of the lectin complement pathway are mannose-binding lectin and Ficolin -1, -2 and -3. Recently deficiency of Ficolin-3 was found to be associated with life threatening infections.
Estrid Hein, Christian Honoré, Mikkel-Ole Skjoedt, Lea Munthe-Fog, Tina Hummelshøj, Peter Garred   +5 more
doaj   +1 more source

Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage [PDF]

Journal of Immunological Methods, 2007
The humoral response to invading pathogens is mediated by a repertoire of innate immune molecules and receptors able to recognize pathogen-associated molecular patterns. Mannose binding lectin (MBL) and ficolins are initiation molecules of the lectin complement pathway (LCP) that bridge innate and adaptive immunity.
Mary C, Walsh, Lisa A, Shaffer, Benjamin J, Guikema, Simon C, Body, Stanton K, Shernan, Amanda A, Fox, Charles D, Collard, Michael, Fung, Ronald P, Taylor, Gregory L, Stahl   +9 more
openaire   +2 more sources