Results 31 to 40 of about 23,299 (223)

A Plausible Role for Collectins in Skin Immune Homeostasis

Frontiers in Immunology, 2021
The skin is a complex organ that faces the external environment and participates in the innate immune system. Skin immune homeostasis is necessary to defend against external microorganisms and to recover from stress to the skin.
Tian Wang, Ke Li, Shengxiang Xiao, Yumin Xia   +3 more
doaj   +1 more source

Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection [PDF]

, 2017
[Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR).
Barge-Caballero, Eduardo, Cid, Javier, Crespo-Leiro, María Generosa, Grille Cancela, Zulaika, Hermida-Prieto, Manuel, Marrón Liñares, Grecia Manuela, Muñiz, Javier, Núñez, Lucía, Paniagua-Martín, María J., Pombo-Otero, Jorge, Rene Rodríguez, E., Suárez-Fuentetaja, Natalia, Tan, Carmela D., Vázquez Rodríguez, José Manuel   +13 more
core   +2 more sources

Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement [PDF]

Journal of Biological Chemistry, 2012
The complement system is a fundamental component of innate immunity that orchestrates complex immunological and inflammatory processes. Complement comprises over 30 proteins that eliminate invading microorganisms while maintaining host cell integrity.
Miller, A, Gor, J, Perkins, SJ, Phillips, A, Wallis, R   +4 more
openaire   +3 more sources

Association of Chlamydia pneumoniae with coronary artery disease and its progression is dependent on the modifying effect of mannose-binding lectin [PDF]

, 2002
Background— The possible association between coronary artery disease (CAD) and Chlamydia pneumoniae (C pneumoniae) infection is controversial. On the basis of the recent suggestion that mannose-binding lectin (MBL) variant alleles are related to an ...
Burián, Katalin, Duba, Jenő, Endrész, Valéria, Füst, György, Garred, Peter, Gönczöl, Éva, Karádi, István, Madsen, Hans O., Prohászka, Zoltán, Romics, László, Rugonfalvi-Kiss, Szabolcs   +10 more
core   +1 more source

The Lectin Pathway of Complement and Rheumatic Heart Disease

Frontiers in Pediatrics, 2015
The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame, Sandra Jeremias Catarino, Isabela eGoeldner, Angelica Beate Winter Boldt, Iara eDe Messias Reason   +4 more
doaj   +1 more source

Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy

Experimental Hematology & Oncology, 2021
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki, Vincent T. Ho, Wilhelm Schwaeble, Thomas Dudler, Mohamed Daha, Teizo Fujita, Sonata Jodele   +6 more
doaj   +1 more source

Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis

Renal Failure, 2022
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima, Dan Inoue, Takeaki Wajima, Takahiro Uchida, Muneharu Yamada, Isao Ohsawa, Takashi Oda   +6 more
doaj   +1 more source

The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway [PDF]

The Journal of Immunology, 2011
Abstract Mannose-binding lectin (MBL)-associated serine proteases (MASPs) are responsible for activation of the lectin complement pathway. Three types of MASPs (MASP-1, MASP-2, and MASP-3) are complexed with MBL and ficolins in serum.
Daisuke, Iwaki, Kazuko, Kanno, Minoru, Takahashi, Yuichi, Endo, Misao, Matsushita, Teizo, Fujita   +5 more
openaire   +2 more sources

Toxoplasma gondii Recruits Factor H and C4b-Binding Protein to Mediate Resistance to Serum Killing and Promote Parasite Persistence in vivo

Frontiers in Immunology, 2020
Regulating complement is an important step in the establishment of infection by microbial pathogens. Toxoplasma gondii actively resists complement-mediated killing in non-immune human serum (NHS) by inactivating C3b, however the precise molecular basis ...
Patricia M. Sikorski, Patricia M. Sikorski, Alessandra G. Commodaro, Michael E. Grigg   +3 more
doaj   +1 more source

Activity of Mannose-Binding Lectin on Bacterial-Infected Chickens—A Review

Animals, 2021
In recent years, diseases caused by pathogenic bacteria have profoundly impacted chicken production by causing economic loss in chicken products and by-product revenues. MBL (mannose-binding lectin) is part of the innate immune system (IIS), which is the
Peter A. Idowu, Adeola P. Idowu, Oliver T. Zishiri, Takalani J. Mpofu, Edwin J. A. Veldhuizen, Khathutshelo A. Nephawe, Bohani Mtileni   +6 more
doaj   +1 more source