Results 51 to 60 of about 23,299 (223)

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses. [PDF]

, 2015
Aspergillus fumigatus is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients leading to a high mortality.
Akaiwa, Ali, Azuma, Balloy, Bidula, Bidula, Bidula, D'Haese, De Pauw, DeHart, Foster, Garlatti, Hammond, Hearn, Hummelshøj, Kenawy, Latge, Le, Luo, Ma, Ma, Ma, Madan, Mambula, Martin, Martinez, Matsushita, Matsushita, Matsushita, Meier, Munthe-Fog, Neth, Romani, Rubino, Schelenz, Schelenz, Steele, Steinbach, Sturtevant, Taccone, Thornton, Torok, Werner, Wetering, Zacho, Zhang, Zhao   +46 more
core   +1 more source

Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance

Angewandte Chemie, EarlyView.
We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu, Xuehan Li, Yu Gao, Shijia Tao, Xiaofei Li, Lemei Zhao, Wenshuai Han, Hao Fan, Ying Qiu, Man Wang, Luying Zhou, Xiaoyan Fang, Wenhua Yang, Haiyang Zhang, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang, Xiangzhao Mao   +18 more
wiley   +2 more sources

Low Mannose-Binding Lectin (MBL) genotype is associated with future cardiovascular events in type 2 diabetic South Asians. A prospective cohort study [PDF]

, 2011
Background: South Asians have a high burden of type 2 diabetes and vascular complications. Vascular inflammation is considered central in the pathophysiology of atherosclerosis, and the complement system is thought to play an important role.
Berger, S.P. (Stefan), Chandie Shaw, P.K. (Prataap), Daha, M.R. (Mohammed), Rabelink, T.J. (Ton J.), Siezenga, M.A. (Machiel)   +4 more
core   +13 more sources

Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes [PDF]

, 2015
Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma.
Bronkhorst, M.W.G.A. (Maarten), Lieshout, E.M.M. (Esther) van, Patka, P. (Peter)   +2 more
core   +2 more sources

The Complement System of Agnathans

Frontiers in Immunology, 2018
Agnathans (lamprey and hagfish) are a group of primitive jawless fish. Jawed vertebrates possess adaptive immunity including immunoglobulins, while agnathans lack immunoglobulins but have alternative adaptive immunity in which variable lymphocyte ...
Misao Matsushita
doaj   +1 more source

Characterization of Mannose Binding Lectin (MBL) Levels in Type-2 Diabetes Mellitus Patients Amongst Pakistani Population

Proceedings, 2023
Introduction: Mannose Binding Lectin (MBL) is a pattern recognizing molecule in the Lectin complement pathway and acts by activating the complement cascade via binding with ligands. There is evidence of increased autoreactivity of Mannose Binding Lectin
Hijab Batool , Muhammad Dilawar Khan, Omar Rasheed Chughtai, Sana Rafaqat, Fouzia Sadiq, Hafiz Muhammad Bilal   +5 more
doaj   +1 more source

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M, Kishore, U, Kouser, L, Nayak, A, Sim, RB, Stover, CM   +5 more
core   +1 more source

Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage [PDF]

Journal of Immunological Methods, 2007
The humoral response to invading pathogens is mediated by a repertoire of innate immune molecules and receptors able to recognize pathogen-associated molecular patterns. Mannose binding lectin (MBL) and ficolins are initiation molecules of the lectin complement pathway (LCP) that bridge innate and adaptive immunity.
Mary C, Walsh, Lisa A, Shaffer, Benjamin J, Guikema, Simon C, Body, Stanton K, Shernan, Amanda A, Fox, Charles D, Collard, Michael, Fung, Ronald P, Taylor, Gregory L, Stahl   +9 more
openaire   +2 more sources

Complement in the homeostatic and ischemic brain [PDF]

, 2015
The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of ischemic tissue
Aivazian, Akita, Alexander, Amara, Arumugam, Atkinson, Austen, Barber, Barber, Bednar, Beek, Bellander, Benard, Benard, Benoit, Boos, Busche, Carmichael, Carmichael, Carmichael, Cavusoglu, Cervera, Chu, Cojocaru, Costa, Cowell, Crane, Cudrici, Davoust, De La Rosa, De Simoni, De Simoni, Di Napoli, Ducruet, Ducruet, Ducruet, Ducruet, Elvington, Elvington, Engstrom, Figueroa, Fisher, Frauenknecht, Garrett, Gasque, Gasque, Gesuete, Gill, Harboe, Harhausen, Heese, Heimann, Hoke, Holers, Huang, Huber-Lang, Hurtado, Iadecola, Imm, Jauneau, Katzan, Kim, Kramer, Kulik, Levi-Strauss, Lew, Li, Li, Lindsberg, Luo, Mack, McMullen, Mead, Mehta, Mocco, Mocco, Mocco, Moriyama, Morrison, Mukherjee, Mukherjee, Murphy, Olsson, Orsini, Osaka, Osthoff, Patel, Pavlovski, Pedersen, Pedersen, Pedersen, Persson, Pisalyaput, Rahpeymai, Ramaglia, Ricklin, Rogers, Rupprecht, Rynkowski, Schafer, Schafer, Schultz, Shinjyo, Soane, Somani, Speidl, Stahel, Stephan, Stevens, Stokowska, Stokowska, Storini, Széplaki, Ten, Ten, Thundyil, Thurman, Tohgi, Van Beek, Vasthare, Wieloch, Williams, Yang, Zee, Zhang, Zhang, Zhang, Zhang, Zhang, Zipfel   +129 more
core   +3 more sources

Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement [PDF]

Molecular Immunology, 2011
Mannose-binding lectin-associated serine proteases-1/3 (MASP-1/3) are essential in activating the alternative pathway (AP) of complement through cleaving pro-factor D (pro-Df) into mature Df. MASP are believed to require binding to mannose binding lectins (MBL) or ficolins (FCN) to carry out their biological activities.
Nirmal K, Banda, Minoru, Takahashi, Kazue, Takahashi, Gregory L, Stahl, Stephanie, Hyatt, Magdalena, Glogowska, Timothy A, Wiles, Yuichi, Endo, Teizo, Fujita, V Michael, Holers, William P, Arend   +10 more
openaire   +2 more sources