Results 1 to 10 of about 43,009 (190)

Role of Mannose-binding Lectin and Association with Microbial Sensitization in a Cohort of Patients with Atopic Dermatitis [PDF]

Acta Dermato-Venereologica, 2023
Atopic dermatitis is a relapsing inflammatory skin condition, in which bacteria, fungi and viruses may colonize the skin and aggravate the condition. Mannose-binding lectin is part of the innate immune system.
Emma Belfrage, Camilla L. Jinnestål, Andreas Jönsen, Anders Bengtsson, Anna Åkesson, Artur Schmidtchen, Andreas Sonesson   +6 more
doaj   +2 more sources

Influence of the presence of mannose-binding lectin polymorphisms on the occurrence of leishmaniasis: a systematic review and meta-analysis [PDF]

Anais Brasileiros de Dermatologia, 2022
Background Leishmaniasis is caused by an intracellular protozoan of the Leishmania genus. Mannose-binding lectin (MBL) is a serum complement protein and recognizes lipoprotein antigens in protozoa and the bacterial plasma membrane. Nucleotide variants in
Wonei de Seixas Vital, Felipe Jules de Araújo Santos, Maurício Leandro Fernandes Gonçalves, Claudia Dantas Comandolli Wyrepkowski, Rajendranath Ramasawmy, Silvania da Conceição Furtado   +5 more
doaj   +2 more sources

Activity of Mannose-Binding Lectin on Bacterial-Infected Chickens—A Review [PDF]

Animals, 2021
In recent years, diseases caused by pathogenic bacteria have profoundly impacted chicken production by causing economic loss in chicken products and by-product revenues. MBL (mannose-binding lectin) is part of the innate immune system (IIS), which is the
Peter A. Idowu, Adeola P. Idowu, Oliver T. Zishiri, Takalani J. Mpofu, Edwin J. A. Veldhuizen, Khathutshelo A. Nephawe, Bohani Mtileni   +6 more
doaj   +2 more sources

Echinococcus multilocularis Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin [PDF]

Pathogens
Alveolar Echinococcosis (AE) is a serious zoonotic disease caused by infection of Echinococcus multilocularis larvae. To survive within the host, E. multilocularis has developed a complex immune evasion mechanism including the inhibition of complement ...
Yuxiao Shao, Meng Xia, Yinghui Song, Yan Yan, Xiaofang Dong, Haoran Zong, Bin Zhan, Yanhai Wang, Limei Zhao   +8 more
doaj   +2 more sources

Steroid‐Refractory Cryptogenic Organising Pneumonia (COP) in a Patient With Mannose‐Binding Lectin (MBL) Deficiency [PDF]

Respirology Case Reports
We report a 67‐year‐old man with a relapse characterised by fever, respiratory failure and bilateral infiltrates following completion of a short‐term empirical methylprednisolone regimen for a similar episode.
Ilias E. Dimeas, Sotirios I. Sinis, Paraskevi Kirgou, Cormac McCarthy, Zoe Daniil   +4 more
doaj   +2 more sources

Mannose binding lectin defects and autoimmune diseases [PDF]

Records of Pharmaceutical & Biomedical Sciences, 2022
Complement system has a very important role in our defense against different pathogens and harmful immune complexes. The lectin pathway of complement system is activated by mannose binding lectin leading to complement cascade ending with the removal of ...
Marwa Azab, Hany Hashem, Emad Eldin Ibrahim, Hoda Abdallah, Ali Abdelrahman, Mohammed Behairy   +5 more
doaj   +1 more source

The ‘involution’ of mannose-binding lectin [PDF]

Human Molecular Genetics, 2005
Mannose-binding lectin (MBL) acts as a serum opsonin in innate immune defense and induces complement activation by the lectin pathway. In humans, low levels of functional serum MBL are caused by the dominant action of three single nucleotide substitutions in exon 1 that disrupt the glycine-rich backbone structure of the protein.
Jeanette, Seyfarth, Peter, Garred, Hans O, Madsen   +2 more
openaire   +2 more sources

Activity of mannose‐binding lectin in centenarians [PDF]

Aging Cell, 2012
SummaryWe analyzed MBL2 gene variants in two cohorts of centenarians, octo‐nonagenarians and nonagenarians, and in the general population, one from Sardinia Island (Italy), recruited in the frame of the AKea study, and another from Campania (southern Italy), to search for haplotypes related to longevity.
TOMAIUOLO, R, RUOCCO, A, SALAPETE, C, CARRU, C, BAGGIO, G, FRANCESCHI, C, ZINELLU, A, VAUPEL, J, BELLIA, Chiara, LO SASSO, Bruna, CIACCIO, Marcello, CASTALDO, G, DEIANA, L.   +12 more
openaire   +4 more sources

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives

Cells, 2021
Betacoronaviruses, responsible for the “Severe Acute Respiratory Syndrome” (SARS) and the “Middle East Respiratory Syndrome” (MERS), use the spikes protruding from the virion envelope to attach and subsequently infect the host cells.
Annick Barre, Els J. M. Van Damme, Mathias Simplicien, Sophie Le Poder, Bernard Klonjkowski, Hervé Benoist, David Peyrade, Pierre Rougé   +7 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source