Results 21 to 30 of about 11,460 (178)

Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo

Immunobiology, 2006
Recent evidence has implicated a role for the MBL‐dependent lectin pathway in gastrointestinal ischemia/reperfusion (I/R)‐induced injury. However, previous studies have implicated IgM and the classical pathway as initiators of complement activation following I/R.
Meghan E, McMullen, Melanie L, Hart, Mary C, Walsh, Jon, Buras, Kazue, Takahashi, Gregory L, Stahl   +5 more
openaire   +2 more sources

The Mannose-Binding Lectin-Pathway Is Involved in Complement Activation in the Course of Renal Ischemia-Reperfusion Injury [PDF]

The American Journal of Pathology, 2004
Ischemia-reperfusion (I/R) is an important cause of acute renal failure (ARF). The complement system appears to be essentially involved in I/R injury. However, via which pathway the complement system is activated and in particular whether the mannose-binding lectin (MBL)-pathway is activated is unclear.
de Vries, B., Walter, S.J., Peutz-Kootstra, C.J., Wolfs, T.G.A.M., van Heurn, L.W., Buurman, W.A.   +5 more
openaire   +2 more sources

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin

mBio, 2011
Mannose-binding lectin (MBL) is a key soluble pathogen recognition protein of the innate immune system that binds specific mannose-containing glycans on the surfaces of microbial agents and initiates complement activation via the lectin pathway.
Panisadee Avirutnan, Richard E. Hauhart, Mary A. Marovich, Peter Garred, John P. Atkinson, Michael S. Diamond   +5 more
doaj   +1 more source

Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway [PDF]

The Journal of Immunology, 2008
Abstract The complement system plays an important role in innate immunity. In the lectin complement pathway, mannose-binding lectin (MBL) and ficolins act as recognition molecules, and MBL-associated serine protease (MASP) is a key enzyme. It has been suggested that MASP-2 is responsible for the activation of C4.
Minoru, Takahashi, Daisuke, Iwaki, Kazuko, Kanno, Yumi, Ishida, Jie, Xiong, Misao, Matsushita, Yuichi, Endo, Shigeto, Miura, Naoto, Ishii, Kazuo, Sugamura, Teizo, Fujita   +10 more
openaire   +2 more sources

Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement [PDF]

Journal of Biological Chemistry, 2012
The complement system is a fundamental component of innate immunity that orchestrates complex immunological and inflammatory processes. Complement comprises over 30 proteins that eliminate invading microorganisms while maintaining host cell integrity.
Miller, A, Gor, J, Perkins, SJ, Phillips, A, Wallis, R   +4 more
openaire   +3 more sources

A Plausible Role for Collectins in Skin Immune Homeostasis

Frontiers in Immunology, 2021
The skin is a complex organ that faces the external environment and participates in the innate immune system. Skin immune homeostasis is necessary to defend against external microorganisms and to recover from stress to the skin.
Tian Wang, Ke Li, Shengxiang Xiao, Yumin Xia   +3 more
doaj   +1 more source

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis [PDF]

The Journal of Immunology, 2016
Abstract Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown. We hypothesized that the pattern recognition molecules (PRMs) from the lectin pathway bind CC and function as an upstream ...
Katrine Pilely, Anne Rosbjerg, Ninette Genster, Peter Gal, Gábor Pál, Bente Halvorsen, Sverre Holm, Pål Aukrust, Siril Skaret Bakke, Bjørnar Sporsheim, Ingunn Nervik, Nathalie Niyonzima, Emil D Bartels, Gregory L Stahl, Tom Eirik Mollnes, Terje Espevik, Peter Garred   +16 more
openaire   +4 more sources

The Lectin Pathway of Complement and Rheumatic Heart Disease

Frontiers in Pediatrics, 2015
The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame, Sandra Jeremias Catarino, Isabela eGoeldner, Angelica Beate Winter Boldt, Iara eDe Messias Reason   +4 more
doaj   +1 more source

Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy

Experimental Hematology & Oncology, 2021
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki, Vincent T. Ho, Wilhelm Schwaeble, Thomas Dudler, Mohamed Daha, Teizo Fujita, Sonata Jodele   +6 more
doaj   +1 more source

Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis

Renal Failure, 2022
Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it
Tadasu Kojima, Dan Inoue, Takeaki Wajima, Takahiro Uchida, Muneharu Yamada, Isao Ohsawa, Takashi Oda   +6 more
doaj   +1 more source