Results 21 to 30 of about 23,299 (223)

Mannose-Binding Lectin Regulates Host Resistance and Pathology during Experimental Infection with Trypanosoma cruzi [PDF]

, 2012
Mannose-binding lectin (MBL) is a humoral pattern-recognition molecule important for host defense. Although recent genetic studies suggest an involvement of MBL/MASP2-associated pathways in Chagas’ disease, it is currently unknown whether MBL plays a ...
Báfica, André, Cheever, Allen W., Ezekowitz, R. Alan B., Gibson, Amanda, Roffê, Ester, Rothfuchs, Antonio Gigliotti, Sher, Alan, Steindel, Mario, Takahashi, Kazue   +8 more
core   +16 more sources

Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins.

PLoS Pathogens, 2022
The complement system is a first-line innate host immune defence against invading pathogens. It is activated via three pathways, termed Classical, Lectin and Alternative, which are mediated by antibodies, carbohydrate arrays or microbial liposaccharides,
Carolina De Marco Verissimo, Heather L Jewhurst, József Dobó, Péter Gál, John P Dalton, Krystyna Cwiklinski   +5 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Ahmed, Bee K. Tan, Botto, Bouyain, Caparros, Carlow, Ceriello, Chaipan, Daniel A. Mitchell, Daniel Zehnder, Devaraj, Elizabeth J. Soilleux, Feinberg, Fernandez-Real, Geijtenbeek, Geijtenbeek, Geijtenbeek, Ghanim, Gringhuis, Guo, Harpal S. Randeva, Held, Hendrik Lehnert, Holman, Ip, Krutzik, Lee, Lillegard, Mitchell, Moller-Kristensen, Nauta, Paidassi, Paul Townsend, Permana, Pohlmann, Reading, Rebecca Ilyas, Robert B. Sim, Russell Wallis, Savill, Schilder, Seelen, Soilleux, Strong, Stuart, Turner, Turner, UKPDS, Wallis, Walport, Walport, Weis, Weis, Worthley, Zeyda   +54 more
core   +1 more source

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin

mBio, 2011
Mannose-binding lectin (MBL) is a key soluble pathogen recognition protein of the innate immune system that binds specific mannose-containing glycans on the surfaces of microbial agents and initiates complement activation via the lectin pathway.
Panisadee Avirutnan, Richard E. Hauhart, Mary A. Marovich, Peter Garred, John P. Atkinson, Michael S. Diamond   +5 more
doaj   +1 more source

Scabies mite inactive serine proteases are potent inhibitors of the human complement lectin pathway. [PDF]

PLoS Neglected Tropical Diseases, 2014
Scabies is an infectious skin disease caused by the mite Sarcoptes scabiei and has been classified as one of the six most prevalent epidermal parasitic skin diseases infecting populations living in poverty by the World Health Organisation.
Simone L Reynolds, Robert N Pike, Angela Mika, Anna M Blom, Andreas Hofmann, Lakshmi C Wijeyewickrema, Dave Kemp, Katja Fischer   +7 more
doaj   +1 more source

Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo

Immunobiology, 2006
Recent evidence has implicated a role for the MBL‐dependent lectin pathway in gastrointestinal ischemia/reperfusion (I/R)‐induced injury. However, previous studies have implicated IgM and the classical pathway as initiators of complement activation following I/R.
Meghan E, McMullen, Melanie L, Hart, Mary C, Walsh, Jon, Buras, Kazue, Takahashi, Gregory L, Stahl   +5 more
openaire   +2 more sources

The Mannose-Binding Lectin-Pathway Is Involved in Complement Activation in the Course of Renal Ischemia-Reperfusion Injury [PDF]

The American Journal of Pathology, 2004
Ischemia-reperfusion (I/R) is an important cause of acute renal failure (ARF). The complement system appears to be essentially involved in I/R injury. However, via which pathway the complement system is activated and in particular whether the mannose-binding lectin (MBL)-pathway is activated is unclear.
de Vries, B., Walter, S.J., Peutz-Kootstra, C.J., Wolfs, T.G.A.M., van Heurn, L.W., Buurman, W.A.   +5 more
openaire   +2 more sources

Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]

, 2019
The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto, Greco A., La Cava M, Lambiase A, Limoli PG, Nebbioso M   +5 more
core   +1 more source

Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway [PDF]

The Journal of Immunology, 2008
Abstract The complement system plays an important role in innate immunity. In the lectin complement pathway, mannose-binding lectin (MBL) and ficolins act as recognition molecules, and MBL-associated serine protease (MASP) is a key enzyme. It has been suggested that MASP-2 is responsible for the activation of C4.
Minoru, Takahashi, Daisuke, Iwaki, Kazuko, Kanno, Yumi, Ishida, Jie, Xiong, Misao, Matsushita, Yuichi, Endo, Shigeto, Miura, Naoto, Ishii, Kazuo, Sugamura, Teizo, Fujita   +10 more
openaire   +2 more sources