Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality [PDF]
Frontiers in Immunology, 2021 BackgroundThe SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Federica Defendi +21 more
doaj +4 more sources
PathogensAlveolar Echinococcosis (AE) is a serious zoonotic disease caused by infection of Echinococcus multilocularis larvae. To survive within the host, E. multilocularis has developed a complex immune evasion mechanism including the inhibition of complement ...
Yuxiao Shao +8 more
doaj +3 more sources
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis. [PDF]
The Journal of Immunology, 2016 Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown.
Genster, Ninette +4 more
core +6 more sources
Mannose-binding Lectin Mediated Complement Pathway in Autoimmune Neurological Disorders
Iranian Journal of Allergy, Asthma and Immunology, 2016 Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous ...
Mehrdad Farrokhi +6 more
doaj +2 more sources
Mannose-binding lectin (MBL) and the lectin complement pathway play a role in cutaneous ischemia and reperfusion injury [PDF]
Innovative Surgical Sciences, 2020 Abstract Objectives Cutaneous ischemia/reperfusion (CI/R) injury has shown to play a significant role in chronic wounds such as decubitus ulcers, diabetic foot ulcers, atherosclerotic lesions, and venous stasis wounds.
Peck Claas-Tido +4 more
doaj +3 more sources
Lyme Borreliosis and Deficient Mannose-Binding Lectin Pathway of Complement [PDF]
The Journal of Immunology, 2014 Abstract Risk factors for the widely endemic and much-debated tick-borne infection, Lyme borreliosis (LB), are unknown. The mannose-binding lectin (MBL) pathway of the complement cascade has an essential role in the eradication of Borrelia burgdorferi.
Sajanti, E. +4 more
openaire +3 more sources
Mannose binding lectin mediated complement pathway in multiple sclerosis [PDF]
Journal of Neuroimmunology, 2011 Role of mannose binding lectin (MBL) complement activation pathway, an arm of innate immunity in multiple sclerosis (MS) was evaluated by analyzing the expression of MBL, MBL-associated serine protease-2 (MASP-2), and functional MBL/MASP-2 mediated C4 cleavage (fMBL) in 87 plasma and cerebrospinal fluid (CSF) samples from MS patients and non-MS ...
Janet Y, Kwok +4 more
openaire +2 more sources
Activation of the alternative complement pathway by mannose-binding lectin via a C2-bypass pathway [PDF]
Microbiology and Immunology, 2011 MBL is a serum lectin that activates the lectin pathway of the complement system. MBL forms complexes with three types of MASPs. Upon binding to Salmonella serogroup C-specific oligosaccharide, MBL activates the alternative pathway via a C2-bypass pathway without involving MASP-2, C2 or C4. We demonstrate that mannan-bound MBL activates the alternative
Koichiro Tateishi, Misao Matsushita
openaire +2 more sources
Interactions of Ficolin and Mannose-Binding Lectin with Fibrinogen/Fibrin Augment the Lectin Complement Pathway [PDF]
Journal of Innate Immunity, 2009 Ficolin and mannose-binding lectin (MBL) are animal lectins that are involved in innate immunity by initiating the lectin complement pathway. Here, we report that interactions between these lectins and fibrinogen/fibrin augment the lectin pathway. An ELISA revealed that recombinant mouse ficolin A (rFcnA), rMBL-A and rMBL-C bind to fibrinogen in a dose-
Yuichi, Endo +5 more
openaire +2 more sources
Small Mannose-Binding Lectin-Associated Protein Plays a Regulatory Role in the Lectin Complement Pathway [PDF]
The Journal of Immunology, 2006 Abstract Mannose-binding lectin (MBL) and ficolins are pattern recognition proteins acting in innate immunity, and they trigger the activation of the lectin complement pathway through MBL-associated serine proteases (MASPs). Upon activation of the lectin pathway, MASP-2 cleaves C4 and C2.
Daisuke, Iwaki +8 more
openaire +2 more sources