Results 11 to 20 of about 11,460 (178)

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality [PDF]

Frontiers in Immunology, 2021
BackgroundThe SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Federica Defendi, Corentin Leroy, Corentin Leroy, Olivier Epaulard, Olivier Epaulard, Giovanna Clavarino, Antoine Vilotitch, Marion Le Marechal, Marie-Christine Jacob, Tatiana Raskovalova, Martine Pernollet, Audrey Le Gouellec, Audrey Le Gouellec, Jean-Luc Bosson, Pascal Poignard, Pascal Poignard, Matthieu Roustit, Matthieu Roustit, Nicole Thielens, Chantal Dumestre-Pérard, Chantal Dumestre-Pérard, Jean-Yves Cesbron   +21 more
doaj   +4 more sources

Echinococcus multilocularis Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin

Pathogens
Alveolar Echinococcosis (AE) is a serious zoonotic disease caused by infection of Echinococcus multilocularis larvae. To survive within the host, E. multilocularis has developed a complex immune evasion mechanism including the inhibition of complement ...
Yuxiao Shao, Meng Xia, Yinghui Song, Yan Yan, Xiaofang Dong, Haoran Zong, Bin Zhan, Yanhai Wang, Limei Zhao   +8 more
doaj   +3 more sources

Mannose-binding Lectin Mediated Complement Pathway in Autoimmune Neurological Disorders

Iranian Journal of Allergy, Asthma and Immunology, 2016
Multiple sclerosis (MS) is a complex, demyelinating disease of the central nervous system (CNS) with variable phenotypic presentations, while Guillain-Barre Syndrome (GBS) is the prototypic acute inflammatory disorder that affects the peripheral nervous ...
Mehrdad Farrokhi, Mehrnoosh Dabirzadeh, Nastaran Dastravan, Masoud Etemadifar, Keyvan Ghadimi, Zahra Saadatpour, Ali Rezaei   +6 more
doaj   +2 more sources

Mannose-binding lectin (MBL) and the lectin complement pathway play a role in cutaneous ischemia and reperfusion injury [PDF]

Innovative Surgical Sciences, 2020
Abstract Objectives Cutaneous ischemia/reperfusion (CI/R) injury has shown to play a significant role in chronic wounds such as decubitus ulcers, diabetic foot ulcers, atherosclerotic lesions, and venous stasis wounds.
Peck Claas-Tido, Strauß Sarah, Stahl Gregory L., Vogt Peter-Maria, Busche Marc N.   +4 more
doaj   +3 more sources

Lyme Borreliosis and Deficient Mannose-Binding Lectin Pathway of Complement [PDF]

The Journal of Immunology, 2014
Abstract Risk factors for the widely endemic and much-debated tick-borne infection, Lyme borreliosis (LB), are unknown. The mannose-binding lectin (MBL) pathway of the complement cascade has an essential role in the eradication of Borrelia burgdorferi.
Sajanti, E., Gröndahl-Yli-Hannuksela K., Kauko, T., He, Q., Hytönen J.   +4 more
openaire   +3 more sources

Mannose binding lectin mediated complement pathway in multiple sclerosis [PDF]

Journal of Neuroimmunology, 2011
Role of mannose binding lectin (MBL) complement activation pathway, an arm of innate immunity in multiple sclerosis (MS) was evaluated by analyzing the expression of MBL, MBL-associated serine protease-2 (MASP-2), and functional MBL/MASP-2 mediated C4 cleavage (fMBL) in 87 plasma and cerebrospinal fluid (CSF) samples from MS patients and non-MS ...
Janet Y, Kwok, Florin, Vaida, Ryan M, Augst, Denise Y, Yu, Kumud K, Singh   +4 more
openaire   +2 more sources

Activation of the alternative complement pathway by mannose-binding lectin via a C2-bypass pathway [PDF]

Microbiology and Immunology, 2011
MBL is a serum lectin that activates the lectin pathway of the complement system. MBL forms complexes with three types of MASPs. Upon binding to Salmonella serogroup C-specific oligosaccharide, MBL activates the alternative pathway via a C2-bypass pathway without involving MASP-2, C2 or C4. We demonstrate that mannan-bound MBL activates the alternative
Koichiro Tateishi, Misao Matsushita
openaire   +2 more sources

Interactions of Ficolin and Mannose-Binding Lectin with Fibrinogen/Fibrin Augment the Lectin Complement Pathway [PDF]

Journal of Innate Immunity, 2009
Ficolin and mannose-binding lectin (MBL) are animal lectins that are involved in innate immunity by initiating the lectin complement pathway. Here, we report that interactions between these lectins and fibrinogen/fibrin augment the lectin pathway. An ELISA revealed that recombinant mouse ficolin A (rFcnA), rMBL-A and rMBL-C bind to fibrinogen in a dose-
Yuichi, Endo, Naomi, Nakazawa, Daisuke, Iwaki, Minoru, Takahashi, Misao, Matsushita, Teizo, Fujita   +5 more
openaire   +2 more sources

Small Mannose-Binding Lectin-Associated Protein Plays a Regulatory Role in the Lectin Complement Pathway [PDF]

The Journal of Immunology, 2006
Abstract Mannose-binding lectin (MBL) and ficolins are pattern recognition proteins acting in innate immunity, and they trigger the activation of the lectin complement pathway through MBL-associated serine proteases (MASPs). Upon activation of the lectin pathway, MASP-2 cleaves C4 and C2.
Daisuke, Iwaki, Kazuko, Kanno, Minoru, Takahashi, Yuichi, Endo, Nicholas J, Lynch, Wilhelm J, Schwaeble, Misao, Matsushita, Masaru, Okabe, Teizo, Fujita   +8 more
openaire   +2 more sources

Mannose-binding lectin deficiency with eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in children: a case series

Journal of Medical Case Reports, 2011
Introduction Eosinophilic meningitis, a potentially fatal disease caused by Angiostrongylus cantonensis, is considered an emerging infectious disease.
de Paula-Almeida Olga, Martínez-Alderete René H, Bu-Coifiu-Fanego Raisa, Dorta-Contreras Alberto J, Padilla-Docal Bárbara, Reiber Hansotto, Jensenius Jens   +6 more
doaj   +1 more source