Results 1 to 10 of about 3,578 (151)

Increased expression of ficolin-1 is associated with airway obstruction in asthma [PDF]

BMC Pulmonary Medicine, 2023
Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao, Kun Tang, Yanjiao Lu, Meijia Wang, Wei Wang, Tongsheng Wang, Yuxia Sun, Jianping Zhao, Yimin Mao   +8 more
doaj   +2 more sources

Collectins and ficolins in neonatal health and disease [PDF]

Frontiers in Immunology, 2023
The immune system starts to develop early in embryogenesis. However, at birth it is still immature and associated with high susceptibility to infection.
Maciej Cedzyński, Anna S. Świerzko
doaj   +2 more sources

The Role of Ficolins in Lung Injury [PDF]

Journal of Innate Immunity
Background: Respiratory diseases seriously threaten human health worldwide, and lung injury is an important component of respiratory disease. Complement activation is an important function of the innate immune system. Complement activation helps the body
Meiyun Zhao, Xiaowu Tan, Xu Wu
doaj   +2 more sources

Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India [PDF]

Scientific Reports
The lectin pathway of complement aids in removing apoptotic cells and maintenance of tissue homeostasis. However, its role in SLE pathogenesis remains unknown.
Kirti Rai, Ridi Khatri, Amrutha Jose, Harshada Konkar, Milind Nadkar, Anjali Rajadhyaksha, Lubka Roumenina, Altaf Parande, Gauthami Bitla, Vijay Padwal, Manisha Madkaikar, Vandana Pradhan   +11 more
doaj   +2 more sources

Ficolins and the Recognition of Pathogenic Microorganisms: An Overview of the Innate Immune Response and Contribution of Single Nucleotide Polymorphisms

Journal of Immunology Research, 2019
Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the innate immune response to numerous pathogens throughout the circulation, as well as within organs. Pathogens are primarily removed by direct opsonisation following
Stefan Bidula, Darren W Sexton, Silke Schelenz   +2 more
exaly   +2 more sources

The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin. [PDF]

PLoS ONE, 2013
Mannan-binding lectin (MBL), ficolins and collectin-11 are known to associate with three homologous modular proteases, the MBL-Associated Serine Proteases (MASPs). The crystal structures of the catalytic domains of MASP-1 and MASP-2 have been solved, but
Christine Gaboriaud, Rajesh Kumar Gupta, Lydie Martin, Monique Lacroix, Laurence Serre, Florence Teillet, Gérard J Arlaud, Véronique Rossi, Nicole M Thielens   +8 more
doaj   +7 more sources

Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [PDF]

Infection and Immunity
Plasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome.
Di Zheng, Natalie Ferrington, Dilini Rathnayake, Wina Hasang, Agersew Alemu, Visopo Harawa, Amalia Karahalios, Phoebe Fitzpatrick, Evelyne Gout, Nicole M. Thielens, Karl Seydel, Terrie E. Taylor, Wilson Mandala, Stephen J. Rogerson, Elizabeth H. Aitken, Louise M. Randall   +15 more
doaj   +2 more sources

Unveiling ficolins: diagnostic and prognostic biomarkers linked to the Tumor Microenvironment in Lung Cancer [PDF]

World Journal of Surgical Oncology
Background Ficolins (FCNs) are a family of proteins, comprising FCN1, FCN2 and FCN3, and integral to the immune system which have been implicated in the onset and progression of tumors.
Zeyu Zhang, Xueyan Geng, Maopeng Yin, Shoucai Zhang, Yingjie Liu, Dongmei Hu, Guixi Zheng   +6 more
doaj   +2 more sources

New and Emerging Biomarkers in Chronic Kidney Disease [PDF]

Biomedicines
Chronic kidney disease (CKD) represents a major and widespread global health challenge. It affects over 800 million people worldwide, which is approximately 13% of the world’s population.
Mikołaj Dopierała, Nadja Nitz, Oliwia Król, Karolina Wasicka-Przewoźna, Krzysztof Schwermer, Krzysztof Pawlaczyk   +5 more
doaj   +2 more sources

Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]

Journal of Translational Medicine
Background Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao, Yanjiao Lu, Kun Tang, Wei Wang, Tongsheng Wang, Yingwei Zhu, Jianping Zhao, Yimin Mao   +7 more
doaj   +2 more sources