Collectins and ficolins in neonatal health and disease [PDF]
Frontiers in Immunology, 2023 The immune system starts to develop early in embryogenesis. However, at birth it is still immature and associated with high susceptibility to infection.
Maciej Cedzyński, Anna S. Świerzko
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The Role of Ficolins in Lung Injury [PDF]
Journal of Innate ImmunityBackground: Respiratory diseases seriously threaten human health worldwide, and lung injury is an important component of respiratory disease. Complement activation is an important function of the innate immune system. Complement activation helps the body
Meiyun Zhao, Xiaowu Tan, Xu Wu
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Increased expression of ficolin-1 is associated with airway obstruction in asthma [PDF]
BMC Pulmonary Medicine, 2023 Background The activated complement cascade is involved in asthmatic airway inflammation. Ficolins are essential for innate immunity and can activate the complement lectin pathway.
Pengfei Gao +8 more
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Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India [PDF]
Scientific ReportsThe lectin pathway of complement aids in removing apoptotic cells and maintenance of tissue homeostasis. However, its role in SLE pathogenesis remains unknown.
Kirti Rai +11 more
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Differential Recognition of Lipopolysaccharide O-Antigens by the Pattern Recognition Molecules Mannan-Binding Lectin and Ficolins of the Complement System [PDF]
Journal of Innate ImmunityIntroduction: The complement system plays a crucial role in bridging innate and adaptive immune responses. When activated, a proteolytic cascade leads to pathogen destruction.
Kirstine Mejlstrup Hymøller +3 more
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Journal of Immunology Research, 2019 Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the innate immune response to numerous pathogens throughout the circulation, as well as within organs. Pathogens are primarily removed by direct opsonisation following
Silke Schelenz +2 more
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Emerging role of ficolins in autoimmune diseases
Pharmacological Research, 2021 Ficolins are pattern-recognition molecules (PRMs) that could form complexes with mannose-binding lectin-associated serine proteases (MASPs) to trigger complement activation via the lectin pathway, thereby mediating a series of immune responses including opsonization, phagocytosis and cytokine production.
Zong Wen Shuai, Qian Wu, Peng Wang
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Complement and transplant-associated thrombotic microangiopathy: Current and future approaches. [PDF]
HemasphereHemaSphere, Volume 10, Issue 4, April 2026.
Cugno M, Onida F, Lämmle B.
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Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis
Autoimmunity, 2020 Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns ...
Cristhine Pieczarka +7 more
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Ficolins and infectious diseases
Virologica Sinica, 2014 Ficolins are serum complement lectins, with a structure similar to mannose-binding lectin (MBL) and lung surfactant protein (SP)-A and SP-D. Ficolins activate the lectin complement system and play important roles in host innate immunity. Ficolins are members of the collectin family of proteins, which act as pattern recognition receptors (PRRs).
Xiao-Lian Zhang, Yushan Ren
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