Results 21 to 30 of about 1,942 (166)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

The Genetics of Ficolins [PDF]

Journal of Innate Immunity, 2009
Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins are part of the innate immune system and function as recognition molecules in the complement system.
Garred, Peter, Honoré, Christian, Ma, Ying Jie, Rørvig, Sara, Cowland, Jack, Borregaard, Niels, Hummelshøj, Tina   +6 more
openaire   +3 more sources

Human L-Ficolin (Ficolin-2) and Its Clinical Significance [PDF]

Journal of Biomedicine and Biotechnology, 2012
Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this
Kilpatrick, David C., Chalmers, James D.
openaire   +4 more sources

Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C [PDF]

PeerJ, 2016
Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation.
Kimball Aaron Geno, Richard E. Kennedy, Patricia Sawyer, Cynthia J. Brown, Moon H. Nahm   +4 more
doaj   +2 more sources

Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA [PDF]

, 2021
Ficolins are recognition proteins of the lectin pathway of the complement system and also play an important role in innate immunity and in the maintenance of tissue homeostasis. They deserve special attention in the context of autoimmunity since they are involved in the uptake of dying cells. Because the monitoring of systemic lupus erythematosus (SLE)
Dumestre-Pérard, Chantal, Thielens, Nicole, M.   +1 more
openaire   +3 more sources

Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway. [PDF]

PLoS ONE, 2012
OBJECTIVES: Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are ...
Inga Thorsen Vengen, Hans O Madsen, Peter Garred, Carl Platou, Lars Vatten, Vibeke Videm   +5 more
doaj   +1 more source

Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

Journal of Neuroinflammation, 2011
Background A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to ...
Füst George, Munthe-Fog Lea, Illes Zsolt, Széplaki Gábor, Molnar Tihamér, Pusch Gabriella, Hirschberg Kristóf, Szegedi Robert, Széplaki Zoltán, Prohászka Zoltán, Skjoedt Mikkel-Ole, Garred Peter   +11 more
doaj   +1 more source

Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours [PDF]

Cancer Immunology, Immunotherapy, 2013
Ficolins are serum pattern recognition molecules. They have opsonic properties and are able to activate complement via the lectin pathway. This paper reports investigations concerning ficolin-2 and ficolin-3 in ovarian cancer (OC). Their serum levels, single nucleotide polymorphisms of the corresponding FCN2 and FCN3 genes and specific mRNA expression ...
Szala, A., Sambor Sawicki, Swierzko, A., Szemraj, J., Marcin Śniadecki, Michalski, M., Kaluzynski, A., Lukasiewicz, J., Maciejewska, A., Dariusz Wydra, Kilpatrick, D., Matsushita, M., Cedzynski, M.   +12 more
openaire   +2 more sources

Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo

Scientific Reports, 2017
Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of infection.
Ninette Genster, Olga Østrup, Camilla Schjalm, Tom Eirik Mollnes, Jack B. Cowland, Peter Garred   +5 more
doaj   +1 more source

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

Viruses, 2021
The complement system represents a crucial part of innate immunity. It contains a diverse range of soluble activators, membrane-bound receptors, and regulators.
Valarmathy Murugaiah, Praveen M. Varghese, Nazar Beirag, Syreeta De Cordova, Robert B. Sim, Uday Kishore   +5 more
doaj   +1 more source