Results 21 to 30 of about 3,647 (206)

A sweet response to a sour situation: The role of soluble pattern recognition receptors in the innate immune response to invasive Aspergillus fumigatus infections [PDF]

, 2016
The complement system plays a key role in host defense against pneumococcal infection. Three different pathways, the classical, alternative and lectin pathways, mediate complement activation.
Bidula, Stefan, Schelenz, Silke
core   +7 more sources

The Complement System in ANCA-Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs. [PDF]

Immun Inflamm Dis
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Sunmboye K, Millan P.
europepmc   +2 more sources

Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C [PDF]

PeerJ, 2016
Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation.
Kimball Aaron Geno, Richard E. Kennedy, Patricia Sawyer, Cynthia J. Brown, Moon H. Nahm   +4 more
doaj   +2 more sources

Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA [PDF]

, 2021
Ficolins are recognition proteins of the lectin pathway of the complement system and also play an important role in innate immunity and in the maintenance of tissue homeostasis. They deserve special attention in the context of autoimmunity since they are involved in the uptake of dying cells. Because the monitoring of systemic lupus erythematosus (SLE)
Dumestre-Pérard, Chantal, Thielens, Nicole, M.   +1 more
openaire   +3 more sources

Structural insights into glycan recognition by plant immune receptors: a comparative perspective with animal innate immune systems. [PDF]

Plant J
SUMMARY Pattern recognition receptors (PRRs) function across diverse eukaryotic organisms as a powerful surveillance system to perceive danger signals and to trigger specific adaptive responses. This complex receptor network constitutes the first layer of perception of the innate immune system of plants and mammals.
Vílchez-Pinto G, Garrido-Arandia M, Molina A, Torres MÁ, Jordá L.   +4 more
europepmc   +2 more sources

Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway. [PDF]

PLoS ONE, 2012
OBJECTIVES: Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are ...
Inga Thorsen Vengen, Hans O Madsen, Peter Garred, Carl Platou, Lars Vatten, Vibeke Videm   +5 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

H-ficolin binds Aspergillus fumigatus leading to activation of the lectin complement pathway and modulation of lung epithelial immune responses. [PDF]

, 2015
Aspergillus fumigatus is an opportunistic fungal pathogen that typically infects the lungs of immunocompromised patients leading to a high mortality.
Akaiwa, Ali, Azuma, Balloy, Bidula, Bidula, Bidula, D'Haese, De Pauw, DeHart, Foster, Garlatti, Hammond, Hearn, Hummelshøj, Kenawy, Latge, Le, Luo, Ma, Ma, Ma, Madan, Mambula, Martin, Martinez, Matsushita, Matsushita, Matsushita, Meier, Munthe-Fog, Neth, Romani, Rubino, Schelenz, Schelenz, Steele, Steinbach, Sturtevant, Taccone, Thornton, Torok, Werner, Wetering, Zacho, Zhang, Zhao   +46 more
core   +1 more source

Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

Journal of Neuroinflammation, 2011
Background A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to ...
Füst George, Munthe-Fog Lea, Illes Zsolt, Széplaki Gábor, Molnar Tihamér, Pusch Gabriella, Hirschberg Kristóf, Szegedi Robert, Széplaki Zoltán, Prohászka Zoltán, Skjoedt Mikkel-Ole, Garred Peter   +11 more
doaj   +1 more source

Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge. [PDF]

, 2015
Invasive aspergillosis is a devastating invasive fungal disease associated with a high mortality rate in the immunocompromised, such as leukaemia patients, transplant patients and those with HIV/AIDS.
Bidula, S, Schelenz, S, Sexton, DW
core   +1 more source