Results 1 to 10 of about 4,930 (172)

Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [PDF]

Infection and Immunity
Plasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome.
Di Zheng, Natalie Ferrington, Dilini Rathnayake, Wina Hasang, Agersew Alemu, Visopo Harawa, Amalia Karahalios, Phoebe Fitzpatrick, Evelyne Gout, Nicole M. Thielens, Karl Seydel, Terrie E. Taylor, Wilson Mandala, Stephen J. Rogerson, Elizabeth H. Aitken, Louise M. Randall   +15 more
doaj   +2 more sources

Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours [PDF]

Cancer Immunology, Immunotherapy, 2013
Ficolins are serum pattern recognition molecules. They have opsonic properties and are able to activate complement via the lectin pathway. This paper reports investigations concerning ficolin-2 and ficolin-3 in ovarian cancer (OC). Their serum levels, single nucleotide polymorphisms of the corresponding FCN2 and FCN3 genes and specific mRNA expression ...
Jolanta Lukasiewicz, Maciej Cedzyński, Dariusz Wydra   +2 more
exaly   +3 more sources

Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]

Journal of Translational Medicine
Background Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao, Yanjiao Lu, Kun Tang, Wei Wang, Tongsheng Wang, Yingwei Zhu, Jianping Zhao, Yimin Mao   +7 more
doaj   +2 more sources

Evaluation of Ficolin-3 deficiency as a risk factor in the development of rheumatic heart disease [PDF]

BMC Research Notes
Objective Ficolin-3 is a crucial protein for the activation of the complement system. Previous work has indicated this protein may play a role in the pathogenesis of rheumatic heart disease (RHD), and it has been hypothesised that ficolin-3 has potential
Zahra Parker, M Taariq Salie, Kélin Engel, Liesl J Zühlke, Mark E Engel, Timothy F Spracklen   +5 more
doaj   +2 more sources

Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India [PDF]

Scientific Reports
The lectin pathway of complement aids in removing apoptotic cells and maintenance of tissue homeostasis. However, its role in SLE pathogenesis remains unknown.
Kirti Rai, Ridi Khatri, Amrutha Jose, Harshada Konkar, Milind Nadkar, Anjali Rajadhyaksha, Lubka Roumenina, Altaf Parande, Gauthami Bitla, Vijay Padwal, Manisha Madkaikar, Vandana Pradhan   +11 more
doaj   +2 more sources

Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins

Genomics, 2004
Ficolin is a collagenous lectin which plays a crucial role in innate immunity. Three and two ficolins have been identified in human and mice, respectively. To identify the mouse homologue of human H-ficolin and to elucidate the orthology between mouse ficolins A/B and human L-/M-ficolins, the gene structures were explored.
Minoru Takahashi, Teizo Fujita
exaly   +3 more sources

Genetic Susceptibility to Rheumatic Heart Disease: A Narrative Literature Review Highlighting Evidence From African Populations and Research Gaps in Sudan. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Rheumatic heart disease (RHD) remains a significant public health burden in low‐ and middle‐income countries, particularly in sub‐Saharan Africa. Although socioeconomic factors contribute to disease persistence, genetic susceptibility plays a critical role in determining progression from Group A Streptococcal infection to ...
Alkhalifamohamed H, Jebreel WMA, Elhassan M, Ali SKM.   +3 more
europepmc   +2 more sources

The Role of Ficolins in Lung Injury. [PDF]

J Innate Immun
Background: Respiratory diseases seriously threaten human health worldwide, and lung injury is an important component of respiratory disease. Complement activation is an important function of the innate immune system. Complement activation helps the body defend against invasion by external microorganisms, whereas excessive complement activation can ...
Zhao M, Tan X, Wu X.
europepmc   +4 more sources

Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1 [PDF]

Cell Communication and Signaling
Background Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the local microenvironment.
Li-Wen Zhu, Zihao Li, Xiaohong Dong, Huadong Wu, Yifan Cheng, Shengnan Xia, Xinyu Bao, Yun Xu, Runjing Cao   +8 more
doaj   +2 more sources

Diagnostic Value of Serum Ficolin-3 and Gal-3 in Sepsis Complicated with Acute Kidney Injury [PDF]

International Journal of General Medicine
Hang Yi,1 Ruiping Ye,2 Jinfeng Wang,3 Lin Gao,4 Weiwei Zhang,4 Chao Liu4 1Department of Intensive Care Medicine, Qianjiang Central Hospital, Qianjiang City, Hubei Province, 433100, People’s Republic of China; 2Department of Intensive Care Medicine, The ...
Yi H, Ye R, Wang J, Gao L, Zhang W, Liu C   +5 more
doaj   +2 more sources