Results 41 to 50 of about 4,930 (172)

Protein Corona Formation on Soft Nanocarriers Under Biomimetic Circulatory Flow

Advanced Materials Interfaces, EarlyView.
A biomimetic venous circulation system is developed to study protein corona formation on soft nanocarriers under physiological shear. Liposomes, PLGA nanoparticles, and lipid‐polymer hybrid nanoparticles acquire largely shared but material‐dependent protein coronas that alter surface properties and suppress cellular uptake, highlighting the importance ...
Anamarija Nikoletić, Dominik Simon Müller, Timon Flathmann, Jakob Steuer, Evangelos Natsaridis, Chiara Candino, Abdullah Kahraman, Oya Tagit   +7 more
wiley   +1 more source

Blood Collection Tubes Influence Serum Ficolin-1 and Ficolin-2 Levels [PDF]

Clinical and Vaccine Immunology, 2013
ABSTRACTThe ficolins are members of a recently discovered family of host innate opsonins that can activate the lectin pathway of complement. The ficolins bind many ligands, although they are typically described as binding acetylated sugars. Ficolin-1 (M-ficolin) and ficolin-2 (L-ficolin) are known to bindStreptococcus pneumoniaeserotypes 19C and 11A ...
Allison M, Brady, Brady L, Spencer, Ann R, Falsey, Moon H, Nahm   +3 more
openaire   +2 more sources

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

Advanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou, Huawei Mu, Xueying Nie, Yue Gao, Hui Wang, Ling Fang, Tiangang Luan, Monthon Ganmanee, Jian‐Wen Qiu, Jin Sun, Jack Chi‐Ho Ip   +10 more
wiley   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia

Clinical and Experimental Immunology, 2012
Summary Ficolins are soluble molecules of the innate immune system that recognize carbohydrate molecules on microbial pathogens, apoptotic and necrotic cells. They act through two distinct routes: initiating the lectin pathway of complement activation and mediating a primitive opsonophagocytosis.
Halmos, Amrita, Rigó, János Jr., Szijártó, János, Füst, György, Prohászka, Zoltán, Molvarec, Attila   +5 more
openaire   +4 more sources

Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy. [PDF]

PLoS Neglected Tropical Diseases, 2017
Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nervous system, leading to a high disability rate and social stigma.
Fabiana Antunes Andrade, Marcia Holsbach Beltrame, Valéria Bumiller Bini, Letícia Boslooper Gonçalves, Angelica Beate Winter Boldt, Iara Jose de Messias-Reason   +5 more
doaj   +1 more source

Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease

Frontiers in Immunology, 2022
Reports conflict regarding which lectin-microbial ligand interactions elicit a protective response from the lectin pathway (LP) of complement. Using fluorescent microscopy, we demonstrate the human lectin ficolin-2 binds to Streptococcus pneumoniae ...
Moon H. Nahm, Jigui Yu, Juan J. Calix, Juan J. Calix, Feroze Ganaie   +4 more
doaj   +1 more source

H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates

Immunobiology, 2012
Serum H-ficolin (ficolin-3) concentrations (n=613) and FCN3 genotypes (n=529) from a large group of neonates are presented. Both pre-term deliveries and low birthweight (independently of gestational age) were significantly associated with low H-ficolin concentrations but not with heterozygosity for the FCN3 1637delC frameshift mutation. The presence of
Mateusz, Michalski, Agnieszka, Szala, Anna, St Swierzko, Jolanta, Lukasiewicz, Anna, Maciejewska, David C, Kilpatrick, Misao, Matsushita, Iwona, Domzalska-Popadiuk, Monika, Borkowska-Klos, Anna, Sokolowska, Jerzy, Szczapa, Czeslaw, Lugowski, Maciej, Cedzynski   +12 more
openaire   +2 more sources

Emerging role of ficolins in autoimmune diseases

Pharmacological Research, 2021
Ficolins are pattern-recognition molecules (PRMs) that could form complexes with mannose-binding lectin-associated serine proteases (MASPs) to trigger complement activation via the lectin pathway, thereby mediating a series of immune responses including opsonization, phagocytosis and cytokine production.
Peng Wang, Qian Wu, Zong-Wen Shuai
openaire   +2 more sources

A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins.

PLoS ONE, 2016
Despite recombinant protein technology development, proteins isolated from natural sources remain important for structure and activity determination. Ficolins represent a class of proteins that are difficult to isolate.
Aleksandra Man-Kupisinska, Mateusz Michalski, Anna Maciejewska, Anna S Swierzko, Maciej Cedzynski, Czeslaw Lugowski, Jolanta Lukasiewicz   +6 more
doaj   +1 more source