Serum opsonin ficolin-A enhances host-fungal interactions and modulates cytokine expression from human monocyte-derived macrophages and neutrophils following Aspergillus fumigatus challenge. [PDF]
, 2015 Invasive aspergillosis is a devastating invasive fungal disease associated with a high mortality rate in the immunocompromised, such as leukaemia patients, transplant patients and those with HIV/AIDS.
Bidula, S, Schelenz, S, Sexton, DW
core +1 more source
Lectin complement pathway initiators after subarachnoid hemorrhage — an observational study
Journal of Neuroinflammation, 2020 Background This exploratory study investigated the time-course of lectin complement pathway (LCP) initiators in cerebrospinal fluid (CSF) and plasma in patients with subarachnoid hemorrhage (SAH), as well as their relationship to delayed cerebral ...
Jeppe Sillesen Matzen +5 more
doaj +1 more source
Molecular interaction between natural IgG and ficolin - Mechanistic insights on adaptive-innate immune crosstalk [PDF]
, 2014 10.1038/srep03675Scientific ...
Anand, Ganesh Srinivasan +4 more
core +1 more source
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis. [PDF]
, 2016 Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate the classical and the alternative complement pathways, but the role of the lectin pathway is unknown.
Genster, Ninette +4 more
core +1 more source
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults
Scientific Reports, 2020 We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as ...
Anna Sokołowska +15 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionFicolin-2 is a serum pattern recognition molecule, involved in complement activation via the lectin pathway. This study aimed to investigate the association of ficolin-2 concentration in cord blood serum with complications related to ...
Gabriela Gajek +16 more
doaj +1 more source
Frequency and distribution of FCN2 and FCN3 functional variants among MBL2 genotypes. [PDF]
, 2016 To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files.
Arnardottir, Margret +2 more
core +1 more source
The Role of Ficolins in Lung Injury. [PDF]
J Innate ImmunBackground: Respiratory diseases seriously threaten human health worldwide, and lung injury is an important component of respiratory disease. Complement activation is an important function of the innate immune system. Complement activation helps the body defend against invasion by external microorganisms, whereas excessive complement activation can ...
Zhao M, Tan X, Wu X.
europepmc +4 more sources
Association of FCN2 polymorphisms and Ficolin-2 levels with dengue fever in Vietnamese patients
International Journal of Infectious Diseases, 2020 Background and objective: The human ficolin-2, encoded by FCN2, recognizes pathogen-associated acetylated residues on their cell surfaces and activates the lectin complement cascade. This study aimed to investigate the contribution of human ficolin-2 and
Ngo Truong Giang +12 more
doaj +1 more source
Ficolins and infectious diseases
Virologica Sinica, 2014 Ficolins are serum complement lectins, with a structure similar to mannose-binding lectin (MBL) and lung surfactant protein (SP)-A and SP-D. Ficolins activate the lectin complement system and play important roles in host innate immunity. Ficolins are members of the collectin family of proteins, which act as pattern recognition receptors (PRRs).
Yushan, Ren +2 more
openaire +3 more sources