Results 31 to 40 of about 4,930 (172)

Ficolin-2 binds to serotype 35B pneumococcus as it does to serotypes 11A and 31, and these serotypes cause more infections in older adults than in children.

PLoS ONE, 2018
Among 98 serotypes of Streptococcus pneumoniae, only a small subset regularly causes invasive pneumococcal diseases (IPD). We previously demonstrated that serotype 11A binds to ficolin-2 and has low invasiveness in children. Epidemiologic data suggested,
K Aaron Geno, Brady L Spencer, Sejong Bae, Moon H Nahm   +3 more
doaj   +1 more source

Association of ficolin-3 with severity and outcome of chronic heart failure.

PLoS ONE, 2013
BackgroundInflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown.
Zoltán Prohászka, Lea Munthe-Fog, Thor Ueland, Timea Gombos, Arne Yndestad, Zsolt Förhécz, Mikkel-Ole Skjoedt, Zoltan Pozsonyi, Alice Gustavsen, Lívia Jánoskuti, István Karádi, Lars Gullestad, Christen P Dahl, Erik T Askevold, George Füst, Pål Aukrust, Tom E Mollnes, Peter Garred   +17 more
doaj   +1 more source

Ficolins and infectious diseases

Virologica Sinica, 2014
Ficolins are serum complement lectins, with a structure similar to mannose-binding lectin (MBL) and lung surfactant protein (SP)-A and SP-D. Ficolins activate the lectin complement system and play important roles in host innate immunity. Ficolins are members of the collectin family of proteins, which act as pattern recognition receptors (PRRs).
Yushan, Ren, Quanquan, Ding, Xiaolian, Zhang   +2 more
openaire   +3 more sources

Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

Journal of Neuroinflammation, 2011
Background A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to ...
Füst George, Munthe-Fog Lea, Illes Zsolt, Széplaki Gábor, Molnar Tihamér, Pusch Gabriella, Hirschberg Kristóf, Szegedi Robert, Széplaki Zoltán, Prohászka Zoltán, Skjoedt Mikkel-Ole, Garred Peter   +11 more
doaj   +1 more source

Local and Systemic Concentrations of Pattern Recognition Receptors of the Lectin Pathway of Complement in a Cohort of Patients With Interstitial Lung Diseases

Frontiers in Immunology, 2020
BackgroundThe role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via ...
Severin Vogt, Severin Vogt, Marten Trendelenburg, Marten Trendelenburg, Marten Trendelenburg, Michael Tamm, Michael Tamm, Daiana Stolz, Daiana Stolz, Katrin Esther Hostettler, Katrin Esther Hostettler, Michael Osthoff, Michael Osthoff, Michael Osthoff   +13 more
doaj   +1 more source

Ficolin-2 amplifies inflammation in macrophage-smooth muscle cell cross-talk and increases monocyte transmigration by mechanisms involving IL-1β and IL-6

Scientific Reports, 2023
Ficolin-2, recently identified in atherosclerotic plaques, has been correlated with future acute cardiovascular events, but its role remains unknown. We hypothesize that it could influence plaque vulnerability by interfering in the cross-talk between ...
Răzvan Daniel Macarie, Monica Mădălina Tucureanu, Letiția Ciortan, Ana-Maria Gan, Elena Butoi, Ileana Mânduțeanu   +5 more
doaj   +1 more source

L-ficolin and H-ficolin in patients with Familial Mediterranean fever [PDF]

Pediatric Rheumatology, 2015
In the present study we performed comparative determination of the blood levels of L-ficolin and H-ficolin, opsonins and the initial components of the complement lectin pathway, in patients with Familial Mediterranean fever (FMF) in attack and attack-free periods and healthy subjects.
Mkrtchyan, G, Boyajyan, A
openaire   +1 more source

Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil

Frontiers in Immunology, 2018
The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens ...
Maria Regina Tizzot, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Hellen Weinschutz Mendes, Marcia Holsbach Beltrame, Edna Reiche, Steffen Thiel, Jens C. Jensenius, Iara J. de Messias-Reason   +8 more
doaj   +1 more source

Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors

Frontiers in Immunology, 2021
Thousands of leprosy patients not only suffer from physical deformities, but also either have or have had hepatitis B virus (HBV) coinfection. Polymorphisms of the complement system modulate susceptibility to leprosy, but genetic susceptibility to past ...
Angelica Beate Winter Boldt, Angelica Beate Winter Boldt, Camila de Freitas Oliveira-Toré, Gabriela Canalli Kretzschmar, Hellen Weinschutz Mendes, Sérvio Túlio Stinghen, Fabiana Antunes Andrade, Valéria Bumiller-Bini, Letícia Boslooper Gonçalves, Anna Carolina de Moraes Braga, Ewalda von Rosen Seeling Stahlke, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Steffen Thiel, Iara José Taborda de Messias-Reason   +15 more
doaj   +1 more source

Functional analysis of Ficolin-3 mediated complement activation.

PLoS ONE, 2010
The recognition molecules of the lectin complement pathway are mannose-binding lectin and Ficolin -1, -2 and -3. Recently deficiency of Ficolin-3 was found to be associated with life threatening infections.
Estrid Hein, Christian Honoré, Mikkel-Ole Skjoedt, Lea Munthe-Fog, Tina Hummelshøj, Peter Garred   +5 more
doaj   +1 more source