Results 51 to 60 of about 7,922 (214)

Blood Collection Tubes Influence Serum Ficolin-1 and Ficolin-2 Levels [PDF]

Clinical and Vaccine Immunology, 2013
ABSTRACTThe ficolins are members of a recently discovered family of host innate opsonins that can activate the lectin pathway of complement. The ficolins bind many ligands, although they are typically described as binding acetylated sugars. Ficolin-1 (M-ficolin) and ficolin-2 (L-ficolin) are known to bindStreptococcus pneumoniaeserotypes 19C and 11A ...
Allison M, Brady, Brady L, Spencer, Ann R, Falsey, Moon H, Nahm   +3 more
openaire   +2 more sources

Landscape of Immune Remodeling and NAP1L1‐Driven Epithelial Reprogramming in Gastric Cancer Metastasis

Chronic Diseases and Translational Medicine, EarlyView.
High‐resolution single‐cell atlas of normal gastric tissue, primary gastric cancer, and metastatic lesions. (A) Schematic diagram of experimental design. (B) Bar plot for qualified cell numbers in each lesion. (C) Cells annotation by canon markers for all cells. (D) Bubble chart for canon marker genes for each cell subtype.
Min Sun, Yuanzhi Wang, Yuqing Zhang, Xiaojuan Wang   +3 more
wiley   +1 more source

Emerging role of ficolins in autoimmune diseases

Pharmacological Research, 2021
Ficolins are pattern-recognition molecules (PRMs) that could form complexes with mannose-binding lectin-associated serine proteases (MASPs) to trigger complement activation via the lectin pathway, thereby mediating a series of immune responses including opsonization, phagocytosis and cytokine production.
Peng Wang, Qian Wu, Zong-Wen Shuai
openaire   +2 more sources

Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease

Frontiers in Immunology, 2022
Reports conflict regarding which lectin-microbial ligand interactions elicit a protective response from the lectin pathway (LP) of complement. Using fluorescent microscopy, we demonstrate the human lectin ficolin-2 binds to Streptococcus pneumoniae ...
Moon H. Nahm, Jigui Yu, Juan J. Calix, Juan J. Calix, Feroze Ganaie   +4 more
doaj   +1 more source

Deciphering the ovarian cancer ascites fluid peptidome [PDF]

, 2014
BACKGROUND: Conventional proteomic approaches have thus far been unable to identify novel serum biomarkers for ovarian cancer that are more sensitive and specific than the current clinically used marker, CA-125.
Anand Bery, Christopher R Smith, Eleftherios P Diamandis, Felix Leung, Vathany Kulasingam   +4 more
core   +2 more sources

Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia

Clinical and Experimental Immunology, 2012
Summary Ficolins are soluble molecules of the innate immune system that recognize carbohydrate molecules on microbial pathogens, apoptotic and necrotic cells. They act through two distinct routes: initiating the lectin pathway of complement activation and mediating a primitive opsonophagocytosis.
Halmos, Amrita, Rigó, János Jr., Szijártó, János, Füst, György, Prohászka, Zoltán, Molvarec, Attila   +5 more
openaire   +4 more sources

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Serum MASP-1 in complex with MBL activates endothelial cells. [PDF]

, 2014
The complement system plays an important role in the induction of inflammation. In this study we demonstrate that the initiation complexes of the lectin pathway, consisting of mannose-binding lectin (MBL) and associated serine proteases (MASPs) elicit ...
Ambrus, Balázs Major, Beinrohr, Dahl, Davis, Degn, Degn, Degn, Degn, Dobó, Dobó, Dobó, Endre Schwaner, Erika Kajdácsi, Gulla, Gál, Hansen, Heja, Heja, Hess, Jensenius, János Rigó, József Dobó, Kidmose, Kocsis, László Cervenak, Matsushita, Matsushita, Matsushita, Megyeri, Megyeri, Márton Megyeri, Møller-Kristensen, Oroszlán, Paréj, Paréj, Péter Gál, Péter K. Jani, Péter Závodszky, Ricklin, Saeed, Skjoedt, Steffen Thiel, Stover, Takahashi, Thiel, Thiel, Thiel, Thiel, Thiel, van der Pol   +50 more
core   +1 more source

H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates

Immunobiology, 2012
Serum H-ficolin (ficolin-3) concentrations (n=613) and FCN3 genotypes (n=529) from a large group of neonates are presented. Both pre-term deliveries and low birthweight (independently of gestational age) were significantly associated with low H-ficolin concentrations but not with heterozygosity for the FCN3 1637delC frameshift mutation. The presence of
Mateusz, Michalski, Agnieszka, Szala, Anna, St Swierzko, Jolanta, Lukasiewicz, Anna, Maciejewska, David C, Kilpatrick, Misao, Matsushita, Iwona, Domzalska-Popadiuk, Monika, Borkowska-Klos, Anna, Sokolowska, Jerzy, Szczapa, Czeslaw, Lugowski, Maciej, Cedzynski   +12 more
openaire   +2 more sources

A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins.

PLoS ONE, 2016
Despite recombinant protein technology development, proteins isolated from natural sources remain important for structure and activity determination. Ficolins represent a class of proteins that are difficult to isolate.
Aleksandra Man-Kupisinska, Mateusz Michalski, Anna Maciejewska, Anna S Swierzko, Maciej Cedzynski, Czeslaw Lugowski, Jolanta Lukasiewicz   +6 more
doaj   +1 more source