Results 61 to 70 of about 4,930 (172)
PLoS ONE, 2012 BackgroundThe innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells.
Christian Gytz Ammitzbøll +7 more
doaj +1 more source
Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?
European Journal of Immunology, Volume 56, Issue 7, July 2026.Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni +4 more
wiley +1 more source
Interferon functional analog activates antiviral Jak/Stat signaling through integrin in an arthropod
Cell Reports, 2021 Summary: Drosophila Vago is a small antiviral peptide. Its ortholog in Culex mosquito was found to be an interferon-like cytokine that limits virus replication through activating Jak/Stat signaling.
Jie Gao +5 more
doaj +1 more source
Human Lectins and Their Roles in Viral Infections
Molecules, 2015 Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that recognise viral pathogen-associated ...
Christopher P. Mason, Alexander W. Tarr
doaj +1 more source
Mouse mannose-binding lectin-A and ficolin-A inhibit lipopolysaccharide-mediated pro-inflammatory responses on mast cells [PDF]
BMB Reports, 2013 It is unknown how soluble pattern-recognition receptors inblood, such as mannose-binding lectin (MBL) and ficolins,modulate mast cell-mediated inflammatory responses. Weinvestigate how mouse MBL-A or ficolin-A regulate mouse bonemarrow-derived mast cells
Ying Jie Ma +5 more
doaj +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
BMC Research Notes, 2021 Objective Ficolin-3 is one of the innate immunity molecules that was thought to play a pivotal role in Streptococcus pyogenes autoimmunity and its complications; rheumatic fever (RF) and rheumatic heart disease (RHD).
Maher H. Gomaa +7 more
doaj +1 more source
Dementia etiology classification using NULISA plasma biomarkers and machine learning
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Accurate ante mortem differentiation among dementia etiologies remains challenging, particularly for atypical or mixed clinical presentations. Multiplexed plasma proteomics paired with supervised machine learning offers a minimally invasive and accessible approach for differential diagnosis.
Kelly N. DuBois +9 more
wiley +1 more source
The Disulfide Bonding Pattern in Ficolin Multimers [PDF]
Journal of Biological Chemistry, 2004 Ficolin is a plasma lectin, consisting of a short N-terminal multimerization domain, a middle collagen domain, and a C-terminal fibrinogen-like domain. The collagen domains assemble the subunits into trimers, and the N-terminal domain assembles four trimers into 12-mers.
Tomoo, Ohashi, Harold P, Erickson
openaire +2 more sources
Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients.
PLoS ONE, 2011 Human Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver.
Tong V Hoang +7 more
doaj +1 more source