Results 61 to 70 of about 7,922 (214)
Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy. [PDF]
PLoS Neglected Tropical Diseases, 2017 Leprosy is a chronic inflammatory disease caused by Mycobacterium leprae that mainly affects the skin and peripheral nervous system, leading to a high disability rate and social stigma.
Fabiana Antunes Andrade +5 more
doaj +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Frontiers in Immunology, 2020 BackgroundThe role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via ...
Severin Vogt +13 more
doaj +1 more source
MASP-1 and MASP-2 Do Not Activate Pro-Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors. [PDF]
, 2016 It had been thought that complement factor D (FD) is activated at the site of synthesis, and only FD lacking a propeptide is present in blood. The serum of mannose-binding lectin-associated serine protease (MASP)-1/3(-/-) mice contains pro-FD and has ...
Andrea Kocsis +10 more
core +1 more source
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein +8 more
wiley +1 more source
Collectins and ficolins in neonatal health and disease
Frontiers in Immunology, 2023 The immune system starts to develop early in embryogenesis. However, at birth it is still immature and associated with high susceptibility to infection. Adaptation to extrauterine conditions requires a balance between colonization with normal flora and protection from pathogens.
Maciej Cedzyński, Anna S. Świerzko
openaire +3 more sources
Human Lectins and Their Roles in Viral Infections
Molecules, 2015 Innate recognition of virus proteins is an important component of the immune response to viral pathogens. A component of this immune recognition is the family of lectins; pattern recognition receptors (PRRs) that recognise viral pathogen-associated ...
Christopher P. Mason, Alexander W. Tarr
doaj +1 more source
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao +3 more
wiley +1 more source
Ficolins and the Fibrinogen-like Domain
Immunobiology, 1998 Ficolins are a group of proteins containing collagen-like and fibrinogen-like (FBG) sequences and they have a similar overall structure to C1q and the collectins. There are two types of ficolin in man: L-ficolin and M-ficolin. L-ficolin is synthesized in the liver and secreted into the plasma.
Lu, J., Le, Y.
openaire +2 more sources
Frontiers in Immunology, 2020 A prospective study of 312 patients [194 with multiple myeloma (MM) and 118 with lymphomas (LYMPH)] receiving high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) was conducted.
Anna S. Świerzko +21 more
doaj +1 more source