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FASEB BioAdvances, Volume 8, Issue 4, April 2026.The graphical abstract contrasts normal and fibrotic lungs, illustrating how miR‐200a mimics suppress PAI‐1 and EMT markers, restore fibrinolysis, and reduce MMP‐driven ECM deposition. This schematic highlights the therapeutic potential of miR‐200a in mitigating pulmonary fibrosis progression.
T. M. Jeena +7 more
wiley +1 more source
The Role of Ficolins in Innate Immunity
Immunobiology, 2002 Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (MBL) are very similar in that both ...
Misao, Matsushita, Teizo, Fujita
openaire +2 more sources
Respiratory Research, 2019 Background The incidence of infectious disease caused by nontuberculous mycobacteria is increasing worldwide. Pulmonary Mycobacterium avium complex (MAC) disease is difficult to treat with chemotherapy, and its mechanism of infection, infection route ...
Tomofumi Kobayashi +10 more
doaj +1 more source
Role of Myeloid-Derived Suppressor Cells in tumor-associated pregnancy [PDF]
, 2012 Cancer progression is dependent, in part, on interactions between tumor cells and the host microenvironment. During pregnancy, physiological changes occur that include inflammation and reduced immunity, both of which can promote tumor growth. Accordingly,
Waeber, S.
core
Genetic variants of innate immune receptors and infections after liver transplantation. [PDF]
, 2017 Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is
Cervera, Carlos +4 more
core +1 more source
Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients.
PLoS ONE, 2011 Human Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver.
Tong V Hoang +7 more
doaj +1 more source
BMC Research Notes, 2021 Objective Ficolin-3 is one of the innate immunity molecules that was thought to play a pivotal role in Streptococcus pyogenes autoimmunity and its complications; rheumatic fever (RF) and rheumatic heart disease (RHD).
Maher H. Gomaa +7 more
doaj +1 more source
The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activation [PDF]
, 2016 Parasitic nematodes manufacture various carbohydratelinked phosphorylcholine (PCh)-containing molecules, including ES-62, a protein with an N-linked glycan terminally substituted with PCh.
Ahmed, Umul Kulthum +5 more
core +1 more source
Reduced Dietary Protein Induces Changes in the Dental Proteome
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 107-127, March 2026.Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs +2 more
wiley +1 more source
BMC Cancer, 2018 Background Radiofrequency ablation (RFA) can not only effectively kill hepatocellular carcinoma (HCC) tumour cells but also release tumour antigens that can provoke an immune response.
Shunli Shen +7 more
doaj +1 more source