Results 81 to 90 of about 4,930 (172)

Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation

Immunobiology, 2005
The serum lectins mannose-binding lectin (MBL), L-ficolin, and H-ficolin are recognition molecules in the lectin complement pathway, which play an important role in innate immunity. To assess involvement of the lectin pathway in the clearance of apoptotic cells, we used flow cytometry to quantify binding of MBL, L-ficolin, and H-ficolin to apoptotic ...
Mikio, Kuraya, Zhenping, Ming, Xianzhou, Liu, Misao, Matsushita, Teizo, Fujita   +4 more
openaire   +2 more sources

Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis.

PLoS ONE, 2015
BackgroundVisceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the lectin complement system and involved in innate immunity.MethodsWe have estimated ficolin-
Anshuman Mishra, Justin S Antony, Pandarisamy Sundaravadivel, Hoang Van Tong, Christian G Meyer, Reshma D Jalli, Thirumalaisamy P Velavan, Kumarasamy Thangaraj   +7 more
doaj   +1 more source

Identification of a Ficolin-like Serum Lectin of the Common Carp as a Novel Homologue of Mammalian Microfibrillar-Associated Protein 4

Journal of Marine Science and Engineering
Serum lectins in vertebrates play crucial roles in innate immunity as recognition molecules for pathogen-associated molecular patterns (PAMPs). In mammals, two major lectins, mannose-binding lectin (MBL) and ficolin, both containing N-terminal collagen ...
Michiyo Kimura, Tomonori Somamoto, Takahiro Nagasawa, Miki Nakao   +3 more
doaj   +1 more source

Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes

Mediators of Inflammation, 2015
Background. The innate immune system may have adverse effects in diabetes and cardiovascular disease. The complement system seems to play a key role through erroneous complement activation via hyperglycaemia-induced neoepitopes.
Charlotte Berg Holt, Jakob Appel Østergaard, Esben Axelgaard, Gitte Krogh Nielsen, Yuichi Endo, Steffen Thiel, Troels Krarup Hansen   +6 more
doaj   +1 more source

Complement and transplant‐associated thrombotic microangiopathy: Current and future approaches

HemaSphere, Volume 10, Issue 4, April 2026.
Massimo Cugno, Francesco Onida, Bernhard Lämmle   +2 more
wiley   +1 more source

Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients.

PLoS ONE, 2013
BackgroundIn HIV-infected patients, prediction of Cytomegalovirus (CMV) disease remains difficult. A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected ...
Adrian Egli, Juliane Schäfer, Michael Osthoff, Steffen Thiel, Christina Mikkelsen, Andri Rauch, Hans H Hirsch, Heiner C Bucher, James Young, Jens C Jensenius, Manuel Battegay, Marten Trendelenburg, Swiss HIV Cohort Study   +12 more
doaj   +1 more source

H-Ficolin

, 2013
H-ficolin is a serum lectin synthesized (as a ~34 kDa polypeptide) predominantly by the liver and lung tissues and is one of the soluble pattern recognition receptors of the innate immune system. It is structurally similar to L- and M- ficolins, but is different in its tissue expression and binding affinities to pathogenic ligands.
Chandrasekhar, Anjana, Dinasarapu, Ashok Reddy, Cedzynski, Maciej, Subramaniam, Shankar   +3 more
openaire   +1 more source

L-Ficolin

, 2013
L-ficolin is a serum lectin synthesized (as a ~37 kDa polypeptide) predominantly by the liver, and is one of the key molecules of the innate immune system. It has an amino (N)-terminal cysteine-rich region, a middle stretch of a collagen-like sequence, and a fibrinogen-like domain in the carboxy (C)-terminus.
Chandrasekhar, Anjana, Dinasarapu, Ashok Reddy, Thiel, Steffen, Subramaniam, Shankar   +3 more
openaire   +1 more source

Plenary Abstracts Session & Oral Presentations

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Complement activation lectin pathway (mannose-binding lectin and ficolin) genes polymorphism as the risk factor of CagA positive chronic Helicobacter pylori infection in adolescents

Инфекция и иммунитет, 2020
Currently, features of the host immune response against Helicobacter pylori (Hp) both regarding establishment of chronic carriage after primary infection as well as a role of impaired immune and inflammatory response in the mechanisms of developing ...
Sergey Yu. Tereshchenko, Marina V. Smolnikova, S. N. Zobova   +2 more
doaj