Association of low ficolin-2 concentration in cord serum with respiratory distress syndrome in preterm newborns [PDF]
Frontiers in Immunology, 2023 IntroductionFicolin-2 is a serum pattern recognition molecule, involved in complement activation via the lectin pathway. This study aimed to investigate the association of ficolin-2 concentration in cord blood serum with complications related to ...
Gabriela Gajek +16 more
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Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. [PDF]
PLoS ONE, 2015 BackgroundVisceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the lectin complement system and involved in innate immunity.MethodsWe have estimated ficolin-
Anshuman Mishra +7 more
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Ficolin-2 amplifies inflammation in macrophage-smooth muscle cell cross-talk and increases monocyte transmigration by mechanisms involving IL-1β and IL-6 [PDF]
Scientific Reports, 2023 Ficolin-2, recently identified in atherosclerotic plaques, has been correlated with future acute cardiovascular events, but its role remains unknown. We hypothesize that it could influence plaque vulnerability by interfering in the cross-talk between ...
Răzvan Daniel Macarie +5 more
doaj +2 more sources
Association of ficolin-3 with severity and outcome of chronic heart failure. [PDF]
PLoS ONE, 2013 BackgroundInflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown.
Zoltán Prohászka +17 more
doaj +8 more sources
Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease [PDF]
Frontiers in Immunology, 2022 Reports conflict regarding which lectin-microbial ligand interactions elicit a protective response from the lectin pathway (LP) of complement. Using fluorescent microscopy, we demonstrate the human lectin ficolin-2 binds to Streptococcus pneumoniae ...
Moon H. Nahm +4 more
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Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C [PDF]
PeerJ, 2016 Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation.
Kimball Aaron Geno +4 more
doaj +3 more sources
Ficolin-2 binds to serotype 35B pneumococcus as it does to serotypes 11A and 31, and these serotypes cause more infections in older adults than in children. [PDF]
PLoS ONE, 2018 Among 98 serotypes of Streptococcus pneumoniae, only a small subset regularly causes invasive pneumococcal diseases (IPD). We previously demonstrated that serotype 11A binds to ficolin-2 and has low invasiveness in children. Epidemiologic data suggested,
K Aaron Geno +3 more
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Association of mannose-binding lectin, ficolin-2 and immunoglobulin concentrations with future exacerbations in patients with chronic obstructive pulmonary disease: secondary analysis of the randomized controlled REDUCE trial [PDF]
Respiratory Research, 2021 Background The innate and adaptive immune system is involved in the airway inflammation associated with acute exacerbations in patients with chronic obstructive pulmonary disease (COPD).
Severin Vogt +8 more
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Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. [PDF]
PLoS ONE, 2013 Human ficolin-2 (ficolin-2/P35) is a lectin complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during Mycobacterium ...
Fengling Luo +7 more
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Ficolin-1 in pediatric Plasmodium falciparum malaria and its possible role in parasite clearance and anemia [PDF]
Infection and ImmunityPlasmodium falciparum malaria causes significant disease, especially in young children. A successful immune response to P. falciparum is a major determinant of clinical outcome.
Di Zheng +15 more
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