Results 11 to 20 of about 5,605 (194)

Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis. [PDF]

PLoS ONE, 2012
BackgroundFicolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study, we analyzed five functional polymorphisms of the FCN2 gene for their possible association with cutaneous leishmaniasis ...
Amal Assaf, Tong Van Hoang, Imad Faik, Toni Aebischer, Peter G Kremsner, Jürgen F J Kun, T P Velavan   +6 more
doaj   +6 more sources

Ficolin-2 binds to HIV-1 gp120 and blocks viral infection [PDF]

Virologica Sinica, 2016
Ficolin-2 is a lectin complement pathway activator present in normal human plasma and usually associated with infectious diseases, but little is known about the role of ficolin-2 in human immunodeficiency virus (HIV) infection. Here, we describe our novel findings that serum ficolin-2 concentrations of 103 HIV-1 patients were much higher compared to ...
Xihui Shen, Rongge Yang, Xiao-Lian Zhang   +2 more
exaly   +5 more sources

Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours [PDF]

Cancer Immunology, Immunotherapy, 2013
Ficolins are serum pattern recognition molecules. They have opsonic properties and are able to activate complement via the lectin pathway. This paper reports investigations concerning ficolin-2 and ficolin-3 in ovarian cancer (OC). Their serum levels, single nucleotide polymorphisms of the corresponding FCN2 and FCN3 genes and specific mRNA expression ...
Agnieszka Szala, Anna St Swierzko, Marcin Sniadecki   +2 more
exaly   +5 more sources

Association of FCN2 polymorphisms and Ficolin-2 levels with dengue fever in Vietnamese patients [PDF]

International Journal of Infectious Diseases, 2020
Background and objective: The human ficolin-2, encoded by FCN2, recognizes pathogen-associated acetylated residues on their cell surfaces and activates the lectin complement cascade. This study aimed to investigate the contribution of human ficolin-2 and
Ngo Truong Giang, Hoang Van Tong, Trinh Huu Nghia, Hoang Vu Hung, Do Tuan Anh, Le Van Nam, Can Van Mao, Nguyen Truong Giang, Le Dinh Thanh, Ho Anh Son, Thirumalaisamy P. Velavan, Quyet Do, Nguyen Linh Toan   +12 more
doaj   +3 more sources

The interaction pattern of murine serum ficolin-A with microorganisms. [PDF]

PLoS ONE, 2012
The ficolins are soluble pattern recognition molecules in the lectin pathway of complement, but the spectrum and mode of interaction with pathogens are largely unknown.
Tina Hummelshøj, Ying Jie Ma, Lea Munthe-Fog, Thomas Bjarnsholt, Claus Moser, Mikkel-Ole Skjoedt, Luigina Romani, Teizo Fujita, Yuichi Endo, Peter Garred   +9 more
doaj   +4 more sources

Lectin pathway components and autoantibodies as novel immunological biomarkers in systemic lupus erythematosus (SLE) patients from Western India [PDF]

Scientific Reports
The lectin pathway of complement aids in removing apoptotic cells and maintenance of tissue homeostasis. However, its role in SLE pathogenesis remains unknown.
Kirti Rai, Ridi Khatri, Amrutha Jose, Harshada Konkar, Milind Nadkar, Anjali Rajadhyaksha, Lubka Roumenina, Altaf Parande, Gauthami Bitla, Vijay Padwal, Manisha Madkaikar, Vandana Pradhan   +11 more
doaj   +2 more sources

Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses [PDF]

Journal of Medical Microbiology, 2019
The liver-expressed pattern recognition receptors (PRRs) mannose binding lectin (MBL), ficolin-2 and ficolin-3 contribute to the innate immune response by activating complement.
Ball, Jonathan K., Goddard, Chun, Horncastle, Emma, Irving, William L., Jalal, Paywast J., King, Barnabas J., Mason, Christopher P., McClure, C. Patrick, Pathak, Monika, Saeed, Amanj, Tarr, Alexander W., Urbanowicz, Richard A.   +11 more
core   +4 more sources

Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT [PDF]

RMD Open
Objective To investigate complement system activation and complement protein levels in relation to radiographic progression in axial spondyloarthritis (axSpA) within a longitudinal randomised controlled trial (RCT) of radiographic axSpA patients ...
Joachim Sieper, Denis Poddubnyy, Joachim Listing, Anne Gitte Loft, Anne Troldborg, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Steffen Thiel, Burkhard Muche, Clara Mistegaard   +11 more
doaj   +2 more sources

Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1 [PDF]

Journal of Translational Medicine
Background Ficolins were originally identified as proteins that bind to transforming growth factor-β1 (TGF-β1). They are capable of activating the complement system through lectin pathway for immune system protection. Ficolin-2 and 3 have been identified
Pengfei Gao, Yanjiao Lu, Kun Tang, Wei Wang, Tongsheng Wang, Yingwei Zhu, Jianping Zhao, Yimin Mao   +7 more
doaj   +2 more sources

Ficolin-2: A potential immune-related therapeutic target with low expression in liver cancer. [PDF]

Front Oncol, 2022
ObjectiveThis study aimed to investigate the role of ficolin-2 (FCN2) in the development and course of hepatocellular carcinoma (HCC) and to contribute to the evolution of innovative HCC therapeutics.MethodsOncomine, GEPIA (Gene Expression Profiling Interactive Analysis), TISIDB (Tumor Immune System Interactions and Drug Bank database), UALCAN ...
Wang LT, Zeng QL, Jiang SL, Chen ZY, Wang XL, Li L, Li X.   +6 more
europepmc   +4 more sources