Clinical associations of complement-activating collectins, collectin-10, collectin-11 and mannose-binding lectin in preterm neonates [PDF]
Frontiers in ImmunologyIntroductionPremature and low-birthweight infants are at especially high risk of perinatal complications, including impaired thermoregulation, infections and respiratory distress.
Maja Kufelnicka-Babout +2 more
exaly +8 more sources
Collectins and ficolins in neonatal health and disease [PDF]
Frontiers in Immunology, 2023 The immune system starts to develop early in embryogenesis. However, at birth it is still immature and associated with high susceptibility to infection.
Maciej Cedzyński, Anna S. Świerzko
doaj +4 more sources
Soluble Collectin 11 (CL-11) Acts as an Immunosuppressive Molecule Potentially Used by Stem Cell-Derived Retinal Epithelial Cells to Modulate T Cell Response [PDF]
Cells, 2023 Retinal pigment epithelium (RPE) cell allotransplantation is seen as a possible solution to retinal diseases. However, the RPE-complement system triggered by the binding of collectin-11 (CL-11) is a potential barrier for RPE transplantation as the ...
Giorgia Fanelli +2 more
exaly +4 more sources
COLEC12 Promotes Tumor Progression and Is Correlated With Poor Prognosis in Gastric Cancer [PDF]
Technology in Cancer Research & Treatment, 2023 Purpose Collectin subfamily member 12, a transmembrane scavenger receptor C-type lectin, is aberrantly expressed in various cancers. However, its physiological role in gastric cancer remains somewhat unclear. This study aimed to investigate the Collectin
Xiangfei Sun PhD +5 more
doaj +2 more sources
Promoting immune defensive responses of epithelial cells in airway disease [PDF]
Frontiers in AllergyThe airway epithelium serves as both a physical barrier and as an active contributor in maintaining immune defense. Upon exposure to external insults such as injury and infection, the epithelium releases alarmins including interleukin-25 (IL-25), IL-33 ...
Michael J. Parnham +2 more
doaj +2 more sources
Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)
Frontiers in Immunology, 2018 Collectin-11 (CL-11) is a pattern recognition molecule of the lectin pathway of complement with diverse functions spanning from host defense to embryonic development.
Rafael Bayarri-Olmos +2 more
exaly +3 more sources
COLEC10 and COLEC11 are new serum biomarkers of chronic liver disease [PDF]
European Journal of Medical ResearchBackground COLEC10 and COLEC11 are presumed to act as pattern recognition receptors to activate the complement system by binding to MASP1. However, it is not clear whether the serum concentrations of COLEC10, COLEC11 and MASP1 can be diagnostic markers ...
Tongguo Yang +7 more
doaj +2 more sources
Collectin-11 promotes fibroblast proliferation and modulates their activation status and extracellular matrix synthesis [PDF]
Frontiers in ImmunologyIntroductionCollectin-11 (CL-11), a recently described soluble C-type lectin, has been shown to stimulate cell proliferation in fibroblasts and melanoma cells. However, its broader influence on fibroblast functions and the specific receptors mediating CL-
Wan-Bing Chen +10 more
doaj +2 more sources
Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease. [PDF]
, 2013 Dry eye disease can cause ocular surface inflammation that disrupts the corneal epithelial barrier. While dry eye patients are known to have an increased risk of corneal infection, it is not known whether there is a direct causal relationship between ...
Evans, David +4 more
core +23 more sources
Surfactant protein A alters endosomal trafficking of influenza A virus in macrophages
Frontiers in Immunology, 2023 Influenza A virus infection (IAV) often leads to acute lung injury that impairs breathing and can lead to death, with disproportionate mortality in children and the elderly. Surfactant Protein A (SP-A) is a calcium-dependent opsonin that binds a variety
Eric Yau +10 more
doaj +1 more source