Results 1 to 10 of about 45,869 (242)

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. [PDF]

PLoS ONE, 2012
The peripheral lungs are a potential entrance portal for nanoparticles into the human body due to their large surface area. The fact that nanoparticles can be deposited in the alveolar region of the lungs is of interest for pulmonary drug delivery ...
Christian A Ruge, Ulrich F Schaefer, Jennifer Herrmann, Julian Kirch, Olga Cañadas, Mercedes Echaide, Jesús Pérez-Gil, Cristina Casals, Rolf Müller, Claus-Michael Lehr   +9 more
doaj   +1 more source

Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]

, 2001
Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Clements JA, Crouch E, deMello DE, Dirksen U, Doyle IR, Fisher JH, Floros J, Glasser SW, Green D, Hawgood S, Ikegami M, Ikegami M, Ikegami M, Kitamura T, Kresch MJ, Madan T, Mahut B, Mason RJ, Myrianthopoulos NC, Nogee LM, Pilot-Matias TJ, Power JHT, Prakash UBS, Reed JA, Robertson B, Rosen SH, Stoll BJ, Tredano M, Vorbroker DK, Wang J-Y   +29 more
core   +1 more source

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis

Clinics, 2019
The relationship between surfactant-associated protein D polymorphisms and chronic obstructive pulmonary disease risk remains controversial. This article is the first to systematically evaluate this relationship.
Yi Liao, ChengLiang Huang, JianRong Wang, XianMing Fan   +3 more
doaj   +1 more source

Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels

Frontiers in Physiology, 2023
Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart ...
Naznin Sultana Remex, Chowdhury S. Abdullah, Richa Aishwarya, Sadia S. Nitu, James Traylor, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Christopher G. Kevil, Christopher G. Kevil, A. Wayne Orr, A. Wayne Orr, Md. Shenuarin Bhuiyan, Md. Shenuarin Bhuiyan   +13 more
doaj   +1 more source

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]

, 2019
Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn, De Smedt, Stefaan, Echaide, Mercedes, Guagliardo, Roberta, Merckx, Pieterjan, Pérez-Gil, Jesus, Raemdonck, Koen, Zamborlin, Agata   +7 more
core   +1 more source

The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia

Respiratory Research, 2005
We have shown previously that surfactant protein D (SP-D) binds and agglutinates Streptococcus pneumoniae in vitro. In this study, the role of SP-D in innate immunity against S.
Andrew PW, Hawgood S, Eggleton P, Clark H, Jounblat R, Kadioglu A   +5 more
doaj   +1 more source

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro

Cellular & Molecular Biology Letters, 2019
Background Pulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress.
Shujun Li, Zhongyi Sun, Tao Chen, Jingjing Pan, Yanqing Shen, Xiaoqing Chen, Xiaoyu Zhou, Rui Cheng, Yang Yang   +8 more
doaj   +1 more source

Recent advances in understanding idiopathic pulmonary fibrosis [PDF]

, 2016
Despite major research efforts leading to the recent approval of pirfenidone and nintedanib, the dismal prognosis of idiopathic pulmonary fibrosis (IPF) remains unchanged.
Daccord, C, Maher, TM
core   +3 more sources

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. [PDF]

, 2016
Based on molecular mechanisms and physiologic data, a strong association has been established between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS).
Meduri, Gianfranco Umberto, Schwingshackl, Andreas   +1 more
core   +1 more source

The importance of surfactant on the development of neonatal pulmonary diseases Síndrome da angustia respiratória aguda e proteinose alveolar congênita

Clinics, 2007
Pulmonary surfactant is a substance composed of a lipoprotein complex that is essential to pulmonary function. Pulmonary surfactant proteins play an important role in the structure, function, and metabolism of surfactant; 4 specific surfactant proteins ...
Priscila Pinheiro Ribeiro Lyra, Edna Maria de Albuquerque Diniz   +1 more
doaj   +1 more source