Pulmonary Surfactant and Drug Delivery: An Interface-Assisted Carrier to Deliver Surfactant Protein SP-D Into the Airways [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 This work is focused on the potential use of pulmonary surfactant to deliver full-length recombinant human surfactant protein SP-D (rhSP-D) using the respiratory air-liquid interface as a shuttle.
Cristina García-Mouton +5 more
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Malondialdehyde Acetaldehyde-Adduction Changes Surfactant Protein D Structure and Function [PDF]
Frontiers in Immunology, 2022 Alcohol consumption with concurrent cigarette smoking produces malondialdehyde acetaldehyde (MAA)-adducted lung proteins. Lung surfactant protein D (SPD) supports innate immunity via bacterial aggregation and lysis, as well as by enhancing macrophage ...
Claire G. Nissen +9 more
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Circulating Surfactant Protein D: A Biomarker for Acute Lung Injury? [PDF]
Biomedicines, 2023 Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases in critically ill patients. The lack of prognostic biomarkers has halted detection methods and effective therapy development. Quantitative biomarker-
Alyssa Elmore +4 more
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Role of Surfactant Protein D in Experimental Otitis Media [PDF]
Journal of Innate Immunity, 2021 Surfactant protein D (SP-D) is a C-type collectin and plays an important role in innate immunity and homeostasis in the lung. This study studied SP-D role in the nontypeable Haemophilus influenzae (NTHi)-induced otitis media (OM) mouse model.
Osama Abdel-Razek +5 more
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Surfactant protein D: prognostic insights and emerging therapeutic roles in cancer [PDF]
Frontiers in ImmunologySurfactant protein D (SP-D), a C-type lectin found at the mucosal surfaces, plays crucial roles in innate immunity and homeostasis of the lung.
Sharon Ajay Mathew +5 more
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Revisiting surfactant protein D: an immune surveillance molecule bridging innate and adaptive immunity [PDF]
Frontiers in ImmunologySurfactant protein D (SP-D) is a C-type lectin that was originally discovered as a lung surfactant associated phospholipid recognising protein. It was originally shown to be of great importance in surfactant turnover and homeostasis in conjunction with ...
Azra Shamim +8 more
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Surfactant proteins A and D: role in the pathogenesis of community-acquired pneumonia and possible predictive perspectives [PDF]
Терапевтический архив, 2020 Community-acquired pneumonia is one of the most common infectious diseases and remains one of the leading causes of death in this group of diseases. Studies of community-acquired pneumonia are extremely relevant for modern clinical practice.
O. S. Kharlamovа +3 more
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Сибирский научный медицинский журнал, 2023 Surfactant proteins SP-A and SP-D, which belong to the family of collagen-containing type C lectins, are used as diagnostic and prognostic markers for many acute and chronic respiratory diseases.
K. Yu. Nikolaev +4 more
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Бюллетень сибирской медицины, 2020 Every year, about six million people die from tobacco use. Respiratory epithelium is the first line of defense against exogenous invasion, in particular, harmful inhaled particles, pathogens and allergens. However, the epithelium of the respiratory tract
O. S. Kharlamovа +3 more
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Association of SP-A and SP-D Surfactant Proteins with the Severity of CommunityAcquired Pneumonia
Неотложная медицинская помощь, 2020 Relevance. In current clinical practice, there is a need for research to find new diagnostic tests for the purpose of determining the patients with the highest risk of death from pneumonia.
O. S. Kharlamova +3 more
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