Circulating Surfactant Protein D: A Biomarker for Acute Lung Injury? [PDF]
Biomedicines, 2023 Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases in critically ill patients. The lack of prognostic biomarkers has halted detection methods and effective therapy development. Quantitative biomarker-
Alyssa Elmore +4 more
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Malondialdehyde Acetaldehyde-Adduction Changes Surfactant Protein D Structure and Function [PDF]
Frontiers in Immunology, 2022 Alcohol consumption with concurrent cigarette smoking produces malondialdehyde acetaldehyde (MAA)-adducted lung proteins. Lung surfactant protein D (SPD) supports innate immunity via bacterial aggregation and lysis, as well as by enhancing macrophage ...
Claire G. Nissen +9 more
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Role of Surfactant Protein D in Experimental Otitis Media [PDF]
Journal of Innate Immunity, 2021 Surfactant protein D (SP-D) is a C-type collectin and plays an important role in innate immunity and homeostasis in the lung. This study studied SP-D role in the nontypeable Haemophilus influenzae (NTHi)-induced otitis media (OM) mouse model.
Osama Abdel-Razek +5 more
doaj +2 more sources
Surfactant protein-D and pulmonary host defense [PDF]
Respiratory Research, 2000 Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial
Crouch Erika C
doaj +3 more sources
The Role of Pulmonary Collectins, Surfactant Protein A (SP-A) and Surfactant Protein D (SP-D) in Cancer. [PDF]
Cancers (Basel)Surfactant proteins A and D (SP-A and SP-D) belong to the collectin subfamily of C-type oligomeric lectins. They are pattern-recognition molecules (PRMs), able to recognise pathogen- or danger-associated molecular patterns (PAMPs, DAMPs) in the presence of Ca2+ cations. That property enables opsonisation or agglutination of non-self or altered/abnormal
Cedzyński M, Świerzko AS.
europepmc +3 more sources
Regulation of surfactant protein D in the rodent prostate [PDF]
Reproductive Biology and Endocrinology, 2007 Background Surfactant protein D (SP-D) is an innate immune protein that is present in mucosal lined surfaces throughout the human body, including the male reproductive tract. In the present study, we characterized the regulation of SP-D expression in the
Maldonado Cristina A +4 more
doaj +3 more sources
Vitamin D Depletion in Pregnancy Decreases Survival Time, Oxygen Saturation, Lung Weight and Body Weight in Preterm Rat Offspring. [PDF]
PLoS ONE, 2016 Animal studies suggest a role of vitamin D in fetal lung development although not studied in preterm animals. We tested the hypothesis that vitamin D depletion aggravates respiratory insufficiency in preterm rat offspring.
Sine Lykkedegn +6 more
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Revisiting surfactant protein D: an immune surveillance molecule bridging innate and adaptive immunity [PDF]
Frontiers in ImmunologySurfactant protein D (SP-D) is a C-type lectin that was originally discovered as a lung surfactant associated phospholipid recognising protein. It was originally shown to be of great importance in surfactant turnover and homeostasis in conjunction with ...
Azra Shamim +8 more
doaj +2 more sources
SFTA2 - a novel secretory peptide highly expressed in the lung - is modulated by lipopolysaccharide but not hyperoxia [PDF]
, 2012 Tissue-specific transcripts are likely to be of importance for the corresponding organ. While attempting to define the specific transcriptome of the human lung, we identified the transcript of a yet uncharacterized protein, SFTA2.
Bretschneider, Nancy +9 more
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Surfactant Protein-D Is Essential for Immunity to Helminth Infection. [PDF]
PLoS Pathogens, 2016 Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control of nematode infections. An important epithelial product is the collectin Surfactant Protein D (SP-D).
Sumaiyya Thawer +14 more
doaj +8 more sources