Surfactant protein-D and pulmonary host defense [PDF]
Respiratory Research, 2000 Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial
Crouch Erika C
doaj +5 more sources
The detection of surfactant proteins A, B, C and D in the human brain and their regulation in cerebral infarction, autoimmune conditions and infections of the CNS. [PDF]
PLoS ONE, 2013 Surfactant proteins (SP) have been studied intensively in the respiratory system. Surfactant protein A and surfactant protein D are proteins belonging to the family of collectins each playing a major role in the innate immune system.
Stefan Schob +7 more
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Surfactant protein A and surfactant protein D in health and disease [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1998 Surfactant protein (SP) A and SP-D are collagenous glycoproteins with multiple functions in the lung. Both of these proteins are calcium-dependent lectins and are structurally similar to mannose-binding protein and bovine conglutinin.
Dennis R. Voelker +2 more
core +3 more sources
Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D.
PLoS ONE, 2013 Lung surfactant is a complex mixture of lipids and proteins, which is secreted from the alveolar type II epithelial cell and coats the surface of alveoli as a thin layer.
Taku Fukuzawa +12 more
doaj +2 more sources
Regulation of surfactant protein D in the rodent prostate [PDF]
Reproductive Biology and Endocrinology, 2007 Background Surfactant protein D (SP-D) is an innate immune protein that is present in mucosal lined surfaces throughout the human body, including the male reproductive tract. In the present study, we characterized the regulation of SP-D expression in the
Maldonado Cristina A +4 more
doaj +3 more sources
Frontiers in Immunology, 2014 Commercial surfactant products derived from animal lungs are used for the treatment of respiratory diseases in premature neonates. These products contain lipids and the hydrophobic surfactant proteins B and C, which help to lower the surface tension in ...
Daniela eSalgado +5 more
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Protective Effect of Surfactant Protein D in Pulmonary Vaccinia Virus Infection: Implication of A27 Viral Protein [PDF]
Viruses, 2013 Vaccinia virus (VACV) was used as a surrogate of variola virus (VARV) (genus Orthopoxvirus), the causative agent of smallpox, to study Orthopoxvirus infection. VARV is principally transmitted between humans by aerosol droplets.
Julien Perino +5 more
doaj +2 more sources
Proteomic and glycomic analyses of a lung-specific protein surfactant protein-D
Data in Brief, 2015 In order to verify the protein enriched from pooled human sera to be a lung-specific protein surfactant protein-D (SP-D), we performed peptide mass fingerprinting (PMF)-based protein identification. MASCOT search results of the obtained PMF unequivocally
Emi Ito +11 more
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Degradation of surfactant protein D by alveolar macrophages
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1998 Surfactant protein (SP) D is a pulmonary surfactant-associated protein that may function in lung host defense. SP-D is produced by alveolar type II cells and nonciliated bronchiolar epithelial (Clara) cells of the airway and is secreted into the air ...
Jo Rae Wright, Qun Dong
core +3 more sources
Surfactant Protein D in Newborn Infants: Factors Influencing Surfactant Protein D Levels in Umbilical Cord Blood and Capillary Blood [PDF]
Pediatric Research, 2005 Surfactant protein D (SP-D) is a collectin that plays an important role in the innate immune system. The role of SP-D in the metabolism of surfactant is as yet quite unclear. The aims of this study were to establish normal values of SP-D in the umbilical
Juvonen, Pekka Olavi +7 more
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