Binding of pulmonary surfactant proteins to carbon nanotubes; potential for damage to lung immune defense mechanisms [PDF]
, 2007 Potential pulmonary toxicity of carbon nanotubes is a research area that has received considerable attention. Surfactant proteins A and D (SP-A and SP-D) are collectin proteins that are secreted by airway epithelial cells in the lung.
Vénien-Bryan, Catherine +6 more
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The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. [PDF]
PLoS ONE, 2012 The peripheral lungs are a potential entrance portal for nanoparticles into the human body due to their large surface area. The fact that nanoparticles can be deposited in the alveolar region of the lungs is of interest for pulmonary drug delivery ...
Christian A Ruge +9 more
doaj +1 more source
Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]
, 2001 Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Griese, Matthias +5 more
core +1 more source
Pulmonary surfactant inactivation by β-D-glucan and protective role of surfactant protein A [PDF]
, 2022 CRUE-CSIC (Acuerdos Transformativos 2021)Pulmonary fungal infections lead to damage of the endogenous lung surfactant system. However, the molecular mechanism underlying surfactant inhibition is unknown.
Casals Carro, María Cristina +7 more
core +1 more source
Surfactant protein A and surfactant protein D variation in pulmonary disease
Immunobiology, 2007 Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate immunity. The proteins are host defense lectins, belonging to the collectin family which also includes mannan-binding lectin (MBL). SP-A and SP-D are pattern-recognition molecules with the lectin domains binding preferentially to sugars on a broad spectrum of pathogen ...
Sørensen, Grith Lykke +2 more
openaire +2 more sources
Surfactant function in neonates with respiratory distress syndrome [PDF]
, 1998 The function of pulmonary surfactant of a group of 14 preterm neonates (birth weight 907 +/- 60 g) who suffered from severe respiratory distress syndrome (RDS) and who had received exogenous bovine lipid extracted surfactant on the first day of life was ...
Griese, Matthias +3 more
core +1 more source
Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]
, 2014 © 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA +52 more
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Surfactant Protein D in Respiratory and Non-Respiratory Diseases
Frontiers in Medicine, 2018 Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune defense and expressed in pulmonary, as well as non-pulmonary, epithelia.
Grith L. Sorensen
doaj +1 more source
S-nitrosylation of surfactant protein-D controls inflammatory function. [PDF]
PLoS Biology, 2008 The pulmonary collectins, surfactant proteins A and D (SP-A and SP-D) have been implicated in the regulation of the innate immune system within the lung. In particular, SP-D appears to have both pro- and anti-inflammatory signaling functions. At present,
Chang-Jiang Guo +8 more
doaj +1 more source
Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome. [PDF]
, 2012 The state of oligomerization of surfactant associated protein-A (SP-A) monomers differs between individuals. This likely affects SP-A's functional properties and could thereby influence clinical status in patients with lung diseases.
Karl Paul +23 more
core +1 more source