Results 31 to 40 of about 985,929 (323)

Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse

Cells, 2021
Mucopolysaccharidosis IIIA (MPS IIIA) is a lysosomal storage disease with significant neurological and skeletal pathologies. Respiratory dysfunction is a secondary pathology contributing to mortality in MPS IIIA patients.
Tamara L. Paget, Emma J. Parkinson-Lawrence, Paul J. Trim, Chiara Autilio, Madhuriben H. Panchal, Grielof Koster, Mercedes Echaide, Marten F. Snel, Anthony D. Postle, Janna L. Morrison, Jésus Pérez-Gil, Sandra Orgeig   +11 more
doaj   +1 more source

Surfactant Protein-D Regulates Surfactant Phospholipid Homeostasis in Vivo [PDF]

Journal of Biological Chemistry, 1998
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used to produce SP-D (+/-) and SP-D (-/-) mice.
T R, Korfhagen, V, Sheftelyevich, M S, Burhans, M D, Bruno, G F, Ross, S E, Wert, M T, Stahlman, A H, Jobe, M, Ikegami, J A, Whitsett, J H, Fisher   +10 more
openaire   +2 more sources

A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples

bioRxiv, 2020
Rationale COVID-19 is an acute infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Human surfactant protein D (SP-D) is known to interact with spike protein of SARS-CoV, but its immune-surveillance against SARS ...
T. Madan, B. Biswas, Praveen M Varghese, Rambhadur P. Subedi, Hrishikesh Pandit, Susan Idicula-Thomas, Indra Kundu, S. Rooge, R. Agarwal, D. Tripathi, S. Kaur, E. Gupta, Sanjeev K Gupta, U. Kishore   +13 more
semanticscholar   +1 more source

Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result. [PDF]

, 2015
In contrast to the probabilistic way of thinking about pleiotropy as the random expression of a single gene that generates two or more distinct phenotypic traits, it is actually a deterministic consequence of the evolution of complex physiology from the ...
Torday, John S
core   +9 more sources

Frog foams and natural protein surfactants [PDF]

, 2017
Foams and surfactants are relatively rare in biology because of their potential to harm cell membranes and other delicate tissues. However, in recent work we have identified and characterized a number of natural surfactant proteins found in the foam ...
Cooper, Alan, Kennedy, Malcolm W., Smith, Brian O., Vance, Steven J.   +3 more
core   +1 more source

On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx [PDF]

, 2020
Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli. The tissue elements that oxygen molecules have to cross are the alveolar epithelium, the interstitium and the capillary endothelium.
Hegermann, Jan, Kuebler, Wolfgang M., Lopez-Rodriguez, Elena, Matuszak, Jasmin, Nouailles, Geraldine, Ochs, Matthias, Simmons, Szandor, Timm, Sara, Witzenrath, Martin   +8 more
core   +1 more source

Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]

, 2001
Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Clements JA, Crouch E, deMello DE, Dirksen U, Doyle IR, Fisher JH, Floros J, Glasser SW, Green D, Hawgood S, Ikegami M, Ikegami M, Ikegami M, Kitamura T, Kresch MJ, Madan T, Mahut B, Mason RJ, Myrianthopoulos NC, Nogee LM, Pilot-Matias TJ, Power JHT, Prakash UBS, Reed JA, Robertson B, Rosen SH, Stoll BJ, Tredano M, Vorbroker DK, Wang J-Y   +29 more
core   +1 more source

Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D.

PLoS ONE, 2013
Lung surfactant is a complex mixture of lipids and proteins, which is secreted from the alveolar type II epithelial cell and coats the surface of alveoli as a thin layer.
Taku Fukuzawa, Junji Ishida, Akira Kato, Taro Ichinose, Donna Maretta Ariestanti, Tomoya Takahashi, Kunitoshi Ito, Jumpei Abe, Tomohiro Suzuki, Shigeharu Wakana, Akiyoshi Fukamizu, Nobuhiro Nakamura, Shigehisa Hirose   +12 more
doaj   +1 more source

The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. [PDF]

PLoS ONE, 2012
The peripheral lungs are a potential entrance portal for nanoparticles into the human body due to their large surface area. The fact that nanoparticles can be deposited in the alveolar region of the lungs is of interest for pulmonary drug delivery ...
Christian A Ruge, Ulrich F Schaefer, Jennifer Herrmann, Julian Kirch, Olga Cañadas, Mercedes Echaide, Jesús Pérez-Gil, Cristina Casals, Rolf Müller, Claus-Michael Lehr   +9 more
doaj   +1 more source

Weak and saturable protein-surfactant interactions in the denaturation of apo-α-lactalbumin by acidic and lactonic sophorolipid [PDF]

, 2016
Biosurfactants are of growing interest as sustainable alternatives to fossil-fuel-derived chemical surfactants, particularly for the detergent industry.
Brian Stougaard Vad, Daniel E Otzen, Inge Van Bogaert, Kell K Andersen, Kell K Andersen, Sophie Roelants   +5 more
core   +2 more sources