Results 21 to 30 of about 17,566,312 (293)

Surfactant Protein-D Is Essential for Immunity to Helminth Infection. [PDF]

PLoS Pathogens, 2016
Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control of nematode infections. An important epithelial product is the collectin Surfactant Protein D (SP-D).
Sumaiyya Thawer, Jennifer Auret, Corinna Schnoeller, Alisha Chetty, Katherine Smith, Matthew Darby, Luke Roberts, Rosie-Marie Mackay, Harry J Whitwell, John F Timms, Jens Madsen, Murray E Selkirk, Frank Brombacher, Howard William Clark, William G C Horsnell   +14 more
doaj   +8 more sources

Roles of surfactant proteins, SP-A and SP-D, in pregnancy and parturition [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Surfactant proteins SP-A and SP-D are important key molecules responsible for pulmonary homeostasis and innate immunity against infectious pathogens.
Karbani, Najmunisa
core   +7 more sources

The Role of Pulmonary Collectins, Surfactant Protein A (SP-A) and Surfactant Protein D (SP-D) in Cancer. [PDF]

Cancers (Basel)
Surfactant proteins A and D (SP-A and SP-D) belong to the collectin subfamily of C-type oligomeric lectins. They are pattern-recognition molecules (PRMs), able to recognise pathogen- or danger-associated molecular patterns (PAMPs, DAMPs) in the presence of Ca2+ cations. That property enables opsonisation or agglutination of non-self or altered/abnormal
Cedzyński M, Świerzko AS.
europepmc   +3 more sources

Surfactant Protein-D and Asthma [PDF]

Chest, 2016
Much of the recent research in asthma has focused on delineating the causative factors that contribute to the pathobiology of both airway eosinophilia and neutrophilia, and steroid-refractory disease. The distal airway, once thought to be a sterile environment, is now known to be a complex arena of microorganisms, termed the lung microbiome ...
Mitchell, Patrick, O'Byrne, Paul
openaire   +2 more sources

Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD

ERJ Open Research, 2022
Rationale Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to prevent alveolar collapse and provides essential immune-regulatory and antipathogenic functions.
Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G. Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley I. Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D. Postle, C. Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples, Tom M.A. Wilkinson, on behalf of the MICA II Study group, Ventzislava A. Hristova   +32 more
doaj   +1 more source

Surfactant protein D modulates HIV infection of both T-cells and dendritic cells [PDF]

, 2013
Surfactant Protein D (SP-D) is an oligomerized C-type lectin molecule with immunomodulatory properties and involvement in lung surfactant homeostasis in the respiratory tract.
Gaiha, Gaurav, Daniel A. Mitchell (223117), Clark Howard W., Madsen, Jens, Gaurav D. Gaiha (199310), Nades Palaniyar (168625), Gaiha, Gaurav D., Palaniyar Nades, Dong Tao, Dong, Tao, Howard W Clark, Jens Madsen (391091), Mitchell Daniel A., Gaurav D. Gaiha, Mitchell, Daniel A., Tao Dong (15551), Palaniyar, Nades, Howard W. Clark (391092), Madsen Jens, Nades Palaniyar, Daniel A Mitchell, Abrams, William R., Tao Dong, Daniel A. Mitchell, Clark, Howard W., Howard W. Clark, Gaurav D Gaiha, Jens Madsen, Gaiha Gaurav D.   +28 more
core   +1 more source

Surfactant Protein-D Regulates Surfactant Phospholipid Homeostasis in Vivo [PDF]

Journal of Biological Chemistry, 1998
Surfactant protein D (SP-D) is a 43-kDa member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the lung. The SP-D gene was targeted by homologous recombination in embryonic stem cells that were used to produce SP-D (+/-) and SP-D (-/-) mice.
T R, Korfhagen, V, Sheftelyevich, M S, Burhans, M D, Bruno, G F, Ross, S E, Wert, M T, Stahlman, A H, Jobe, M, Ikegami, J A, Whitsett, J H, Fisher   +10 more
openaire   +2 more sources

Increased Alveolar Heparan Sulphate and Reduced Pulmonary Surfactant Amount and Function in the Mucopolysaccharidosis IIIA Mouse

Cells, 2021
Mucopolysaccharidosis IIIA (MPS IIIA) is a lysosomal storage disease with significant neurological and skeletal pathologies. Respiratory dysfunction is a secondary pathology contributing to mortality in MPS IIIA patients.
Tamara L. Paget, Emma J. Parkinson-Lawrence, Paul J. Trim, Chiara Autilio, Madhuriben H. Panchal, Grielof Koster, Mercedes Echaide, Marten F. Snel, Anthony D. Postle, Janna L. Morrison, Jésus Pérez-Gil, Sandra Orgeig   +11 more
doaj   +1 more source

Analysis of lung surfactant phosphatidylcholine metabolism in transgenic mice using stable isotopes [PDF]

, 2011
Stable isotope labelling of lipid precursors coupled with mass spectrometry-based lipidomic analyses and determination of isotope enrichment in substrate, intermediate and product pools provide the parameters needed to determine absolute flux rates ...
Grielof Koster, Koster, G., Howard W. Clark, Clark, Howard, Anthony D. Postle, Neil G. Henderson, Henderson, N.J., Alan N. Hunt, Postle, A.D., Hunt, A.N.   +9 more
core   +1 more source

AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid. [PDF]

, 2007
BACKGROUND: Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV).
Ed Zijlstra, Jambo Kondwani C, Zijlstra, Ed, Jambo, Kondwani C, Gordon, Stephen, French Neil, Kondwani C Jambo, Neil French, Stephen B Gordon, French, Neil, Gordon, Stephen B, Zijlstra Ed, Gordon Stephen B, Kondwani C Jambo, Jambo, Kondwani; id_orcid   +14 more
core   +2 more sources