Frontiers in Bioengineering and Biotechnology, 2021 This work is focused on the potential use of pulmonary surfactant to deliver full-length recombinant human surfactant protein SP-D (rhSP-D) using the respiratory air-liquid interface as a shuttle.
Cristina García-Mouton +5 more
doaj +3 more sources
Correlation of a combined serum biomarker panel with the composite physiologic index in connective tissue disease-associated interstitial lung disease [PDF]
Frontiers in PhysiologyBackgroundTo evaluate the diagnostic performance of a combined serum biomarker panel for connective tissue disease-associated interstitial lung disease (CTD-ILD) and its correlation with disease severity.MethodsThis retrospective, cross-sectional study ...
Haiyan Zhou +6 more
doaj +2 more sources
Krebs von den Lungen-6 as a potent indicator of the frequency of chronic obstructive pulmonary disease exacerbation [PDF]
Journal of International Medical ResearchObjective To evaluate the potential of systemic Krebs von den Lungen-6 level in predicting acute exacerbations of chronic obstructive pulmonary disease.
Jianhui Chen +3 more
doaj +2 more sources
Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome. [PDF]
, 2012 The state of oligomerization of surfactant associated protein-A (SP-A) monomers differs between individuals. This likely affects SP-A's functional properties and could thereby influence clinical status in patients with lung diseases.
Ballmann, Manfred +7 more
core +25 more sources
Sorcin regulates alveolarization and airway tissue remodeling during lung morphogenesis [PDF]
Cellular and Molecular Life SciencesSorcin, a key calcium-sensing protein, regulates calcium concentration within the endoplasmic reticulum (ER), promoting apoptosis resistance and ER stress.
Claudia Tito +12 more
doaj +2 more sources
Surfactant Protein A and Microbiome Composition in Patients With Atraumatic Intraoral Lesions
Frontiers in Oral Health, 2021 Oral ulcers are lesions that occur due to disruption of epithelial integrity of the mucosa of the oral cavity. Intraoral ulcers are often associated with pain, redness, symptoms of discomfort, and blood hemorrhage.
Shawn Adibi +5 more
doaj +1 more source
Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were ...
Lucas Souto Nacif +6 more
doaj +1 more source
Gene Therapy Potential for Genetic Disorders of Surfactant Dysfunction
Frontiers in Genome Editing, 2022 Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in premature infants, severe RDS in term and late preterm infants ...
Ashley L. Cooney +6 more
doaj +1 more source
LAMP3 deficiency affects surfactant homeostasis in mice.
PLoS Genetics, 2021 Lysosome-associated membrane glycoprotein 3 (LAMP3) is a type I transmembrane protein of the LAMP protein family with a cell-type-specific expression in alveolar type II cells in mice and hitherto unknown function.
Lars P Lunding +12 more
doaj +1 more source
Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result. [PDF]
, 2015 In contrast to the probabilistic way of thinking about pleiotropy as the random expression of a single gene that generates two or more distinct phenotypic traits, it is actually a deterministic consequence of the evolution of complex physiology from the ...
Torday, John S
core +9 more sources