Results 21 to 30 of about 50,195 (270)

Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]

, 2001
Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Clements JA, Crouch E, deMello DE, Dirksen U, Doyle IR, Fisher JH, Floros J, Glasser SW, Green D, Hawgood S, Ikegami M, Ikegami M, Ikegami M, Kitamura T, Kresch MJ, Madan T, Mahut B, Mason RJ, Myrianthopoulos NC, Nogee LM, Pilot-Matias TJ, Power JHT, Prakash UBS, Reed JA, Robertson B, Rosen SH, Stoll BJ, Tredano M, Vorbroker DK, Wang J-Y   +29 more
core   +1 more source

Establishment and validation of nomogram for predicting immuno checkpoint inhibitor related pneumonia

BMC Pulmonary Medicine, 2022
Objective Cancer is one of the main causes of death worldwide. Although immunotherapy brings hope for cancer treatment, it is also accompanied by immune checkpoint inhibitor-related adverse events (irAEs). Immune checkpoint inhibitor pneumonia (CIP) is a
Xiaoqi Li, Fei Lv, Ying Wang, Zhenguang Du   +3 more
doaj   +1 more source

Intratracheal Keratinocyte Growth Factor Enhances Surfactant Protein B Expression in Mechanically Ventilated Preterm Pigs

Frontiers in Pediatrics, 2021
Bronchopulmonary dysplasia (BPD) is a devastating disease of prematurity that is associated with mechanical ventilation and hyperoxia. We used preterm pigs delivered at gestational day 102 as a translational model for 26–28-week infants to test the ...
Ramesh Krishnan, Esmond L. Arrindell, Caminita Frank, Zhang Jie, Randal K. Buddington   +4 more
doaj   +1 more source

Surfactant gene polymorphisms and interstitial lung diseases

Respiratory Research, 2001
Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function.
Pantelidis Panagiotis, Veeraraghavan Srihari, du Bois Roland M   +2 more
doaj   +1 more source

Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels

Frontiers in Physiology, 2023
Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart ...
Naznin Sultana Remex, Chowdhury S. Abdullah, Richa Aishwarya, Sadia S. Nitu, James Traylor, Brandon Hartman, Judy King, Mohammad Alfrad Nobel Bhuiyan, Christopher G. Kevil, Christopher G. Kevil, A. Wayne Orr, A. Wayne Orr, Md. Shenuarin Bhuiyan, Md. Shenuarin Bhuiyan   +13 more
doaj   +1 more source

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]

, 2019
Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn, De Smedt, Stefaan, Echaide, Mercedes, Guagliardo, Roberta, Merckx, Pieterjan, Pérez-Gil, Jesus, Raemdonck, Koen, Zamborlin, Agata   +7 more
core   +1 more source

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro

Cellular & Molecular Biology Letters, 2019
Background Pulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress.
Shujun Li, Zhongyi Sun, Tao Chen, Jingjing Pan, Yanqing Shen, Xiaoqing Chen, Xiaoyu Zhou, Rui Cheng, Yang Yang   +8 more
doaj   +1 more source

Recent advances in understanding idiopathic pulmonary fibrosis [PDF]

, 2016
Despite major research efforts leading to the recent approval of pirfenidone and nintedanib, the dismal prognosis of idiopathic pulmonary fibrosis (IPF) remains unchanged.
Daccord, C, Maher, TM
core   +3 more sources

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. [PDF]

, 2016
Based on molecular mechanisms and physiologic data, a strong association has been established between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS).
Meduri, Gianfranco Umberto, Schwingshackl, Andreas   +1 more
core   +1 more source

Association of Surfactant-Associated Protein D Gene Polymorphisms with the Risk of COPD: a Meta-Analysis

Clinics, 2019
The relationship between surfactant-associated protein D polymorphisms and chronic obstructive pulmonary disease risk remains controversial. This article is the first to systematically evaluate this relationship.
Yi Liao, ChengLiang Huang, JianRong Wang, XianMing Fan   +3 more
doaj   +1 more source