Human amniotic membrane as newly identified source of amniotic fluid pulmonary surfactant [PDF]
Scientific Reports, 2017 Pulmonary surfactant (PS) reduces surface tension at the air-liquid interface in the alveolar epithelium of the lung, which is required for breathing and for the pulmonary maturity of the developing foetus.
Angela Lemke +7 more
doaj +3 more sources
Sorcin regulates alveolarization and airway tissue remodeling during lung morphogenesis [PDF]
Cellular and Molecular Life SciencesSorcin, a key calcium-sensing protein, regulates calcium concentration within the endoplasmic reticulum (ER), promoting apoptosis resistance and ER stress.
Claudia Tito +12 more
doaj +2 more sources
The Pulmonary Surfactant: Impact of Tobacco Smoke and Related Compounds on Surfactant and Lung Development [PDF]
Tobacco Induced Diseases, 2004 Cigarette smoking, one of the most pervasive habits in society, presents many well established health risks. While lung cancer is probably the most common and well documented disease associated with tobacco exposure, it is becoming clear from recent ...
J. Elliott Scott
doaj +2 more sources
Intra- and extrapulmonary lipopolysaccharides-induced acute lung injury and pharmacotherapeutic response patterns in ventilated 7-day-old rabbits [PDF]
Experimental Biology and MedicineWe explored pharmacotherapeutic response patterns of lipopolysaccharides (LPS)-induced pneumonia and sepsis as direct and indirect acute lung injury (ALI), and efficacy of a combined surfactant (S) and inhaled nitric oxide (iNO), simulating critical care,
Guiyin Zhuang +4 more
doaj +2 more sources
Surfactant protein a in cystic fibrosis: supratrimeric structure and pulmonary outcome. [PDF]
, 2012 The state of oligomerization of surfactant associated protein-A (SP-A) monomers differs between individuals. This likely affects SP-A's functional properties and could thereby influence clinical status in patients with lung diseases.
Ballmann, Manfred +7 more
core +25 more sources
CAN PULMONARY SURFACTANT PROTEINS BE RELIABLE INDICATORS OF COVID-19-ASSOCIATED PULMONARY INJURY?
Central Asian Journal of Medical Hypotheses and Ethics, 2022 The COVID-19 pandemic is still raging all over the world. New variants of the coronavirus emerge and infect recovered from previous infections, vaccinated, and unvaccinated subjects.
Yuliya Fedorchenko, Olena Zimba
doaj +1 more source
Genetic risk factors associated with respiratory distress syndrome [PDF]
Korean Journal of Pediatrics, 2014 Respiratory distress syndrome (RDS) among preterm infants is typically due to a quantitative deficiency of pulmonary surfactant. Aside from the degree of prematurity, diverse environmental and genetic factors can affect the development of RDS.
Heui Seung Jo
doaj +1 more source
Frontiers in Immunology, 2021 Alveolar macrophages are responsible for clearance of airborne dust and pathogens. How they recognize and phagocytose a variety of engineered nanomaterials (ENMs) with different properties is an important issue for safety assessment of ENMs.
Qiqi Wang +10 more
doaj +1 more source
Gene Therapy Potential for Genetic Disorders of Surfactant Dysfunction
Frontiers in Genome Editing, 2022 Pulmonary surfactant is critically important to prevent atelectasis by lowering the surface tension of the alveolar lining liquid. While respiratory distress syndrome (RDS) is common in premature infants, severe RDS in term and late preterm infants ...
Ashley L. Cooney +6 more
doaj +1 more source
Cellular & Molecular Biology Letters, 2023 Background The pulmonary surfactant that lines the air–liquid surface within alveoli is a protein–lipid mixture essential for gas exchange. Surfactant lipids and proteins are synthesized and stored in the lamellar body (LB) before being secreted from ...
Wenqin Xu +6 more
doaj +1 more source