Results 1 to 10 of about 42,400 (118)

Potential Therapeutic Applications of Pulmonary Surfactant Lipids in the Host Defence Against Respiratory Viral Infections

Frontiers in Immunology, 2021
Pulmonary surfactant is a complex and highly surface-active material. It covers the alveolar epithelium and consists of 90% lipids and 10% proteins. Pulmonary surfactant lipids together with pulmonary surfactant proteins facilitate breathing by reducing ...
Jianjian Ji, Ling Sun, Zichen Luo, Ying Zhang, Wang Xianzheng, Yingzhao Liao, Xie Tong, Jinjun Shan   +7 more
doaj   +3 more sources

Pulmonary surfactant and prostaglandin E2 in airway smooth muscle relaxation of human and male guinea pigs [PDF]

Physiological Reports
Pulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β2‐agonists, anticholinergics, nitric oxide, and prostanoids. The exact mechanism
J. Hanusrichterova, M. Kolomaznik, R. Barosova, J. Adamcakova, D. Mokra, J. Mokry, H. Skovierova, M. M. Kelly, E. deHeuvel, S. Wiehler, D. Proud, H. Shen, P. G. Mukherjee, M. W. Amrein, A. Calkovska   +14 more
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Insights Gained Into the Treatment of COVID19 by Pulmonary Surfactant and Its Components

Frontiers in Immunology, 2022
Pulmonary surfactant constitutes an important barrier that pathogens must cross to gain access to the rest of the organism via the respiratory surface.
Dan Li, Dan Li, Xianzheng Wang, Yingzhao Liao, Shouchuan Wang, Jinjun Shan, Jianjian Ji   +6 more
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Revisiting the role of pulmonary surfactant in chronic inflammatory lung diseases and environmental exposure

European Respiratory Review, 2021
Pulmonary surfactant is a crucial and dynamic lung structure whose primary functions are to reduce alveolar surface tension and facilitate breathing.
Nadia Milad, Mathieu C. Morissette
doaj   +1 more source

Pulmonary surfactant in COVID-19; A role in etiology and treatment [PDF]

المجلة العراقية للصيدلة, 2020
Introduction: Today, SARS-COV-2 infection represents a global threat. Dealing with this viral infection necessitates a comprehensive understanding of pathophysiology of the disease to reach to the suitable treatment.
Myasar Alkotaji, Musab Khalaf
doaj   +1 more source

Effect of Nebulized Bovine Surfactant for Experimental Otitis Media with Effusion [PDF]

Clinical and Experimental Otorhinolaryngology, 2010
ObjectivesIn this study, we evaluated the efficacy of nebulized bovine pulmonary surfactant on experimentally induced otitis media with effusion (OME) in guinea pigs.MethodsTwenty guinea pigs were divided into three groups.
Chul Ho Jang, Yong Bum Cho, Seung Eun Oh, Jeong Uk Choi, Haekyun Park, Cheol Hee Choi   +5 more
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Genetic disorders of the surfactant system: focus on adult disease

European Respiratory Review, 2021
Genes involved in the production of pulmonary surfactant are crucial for the development and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a spectrum of severe monogenic pulmonary diseases in patients of all ages. The
Coline H.M. van Moorsel, Joanne J. van der Vis, Jan C. Grutters   +2 more
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Generation of an induced pluripotent stem cell line from a patient with surfactant metabolism dysfunction carrying ABCA3 mutations

Stem Cell Research, 2021
Surfactant dysfunction is a genetically heterogeneous pulmonary disease that causes dyspnea. ATP binding cassette protein transporter subunit A3 (ABCA3) is the main pathogenic gene of pulmonary surfactant dysfunction.
Xiaojuan Yin, Danhua Zhao, Zhichen Tian, Jia Chen, Jinghan Chi, Yan Ke, Liu He, Xuan Zhang, Yanmei He, Zhichun Feng   +9 more
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Alveolar lipids in pulmonary disease. A review

Lipids in Health and Disease, 2020
Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is composed by multiple cell types with specialized functions and coordinately acting to meet specific physiologic requirements. The alveoli are the niche of the most
Christina W. Agudelo, Ghassan Samaha, Itsaso Garcia-Arcos   +2 more
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Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD).

PLoS ONE, 2020
Smoke exposure is known to decrease total pulmonary surfactant and alter its composition, but the role of surfactant in chronic obstructive pulmonary disease (COPD) remains unknown. We aimed to analyze the compositional changes in the surfactant lipidome
Christina W Agudelo, Britta K Kumley, Estela Area-Gomez, Yimeng Xu, Abdoulaye J Dabo, Patrick Geraghty, Michael Campos, Robert Foronjy, Itsaso Garcia-Arcos   +8 more
doaj   +1 more source