Results 11 to 20 of about 40,759 (154)

The role of surfactant proteins SP-A and SP-D in viral infection: a focus on COVID-19

Бюллетень сибирской медицины, 2022
An immune response to invasion of viral pathogens is an integral part of maintaining the physiological functioning of the bronchopulmonary system and effective gas exchange.
O. S. Kharlamovа, K. Yu. Nikolaev, Yu. I. Ragino   +2 more
doaj   +1 more source

Dimerization of the pulmonary surfactant protein C in a membrane environment.

PLoS ONE, 2022
Surfactant protein C (SP-C) has several functions in pulmonary surfactant. These include the transfer of lipids between different membrane structures, a role in surfactant recycling and homeostasis, and involvement in modulation of the innate defense ...
Hanna Korolainen, Fabio Lolicato, Giray Enkavi, Jesús Pérez-Gil, Waldemar Kulig, Ilpo Vattulainen   +5 more
doaj   +1 more source

On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx [PDF]

, 2020
Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli. The tissue elements that oxygen molecules have to cross are the alveolar epithelium, the interstitium and the capillary endothelium.
Hegermann, Jan, Kuebler, Wolfgang M., Lopez-Rodriguez, Elena, Matuszak, Jasmin, Nouailles, Geraldine, Ochs, Matthias, Simmons, Szandor, Timm, Sara, Witzenrath, Martin   +8 more
core   +1 more source

Identification of protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid

Scientific Reports, 2023
Congenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure.
Sumit Bhutada, Karin Tran-Lundmark, Benjamin Kramer, Peter Conner, Ashley M. Lowry, Eugene Blackstone, Bjorn Frenckner, Carmen Mesas-Burgos, Suneel S. Apte   +8 more
doaj   +1 more source

Immunohistochemical evaluation of surfactant-associated protein in fibrosis-cavernous pulmonary tuberculosis

Инновационная медицина Кубани, 2019
Background. Despite the progress and development of scientific directions in various fields of medicine, the problem of tuberculosis and its morphological manifestations remains relevant and is not fully disclosed due to complex pathogenesis, the ...
E. P. Golubinskaya, T. G. Filonenko, Yu. A. Yermola, A. V. Kubyshkin, M. A. Kalfa, T. V. Kramar, A. V. Geraschenko   +6 more
doaj   +1 more source

Clinical biological and genetic heterogeneity of the inborn errors of pulmonary surfactant metabolism [PDF]

, 2001
Pulmonary surfactant is a multimolecular complex located at the air-water interface within the alveolus to which a range of physical (surface-active properties) and immune functions has been assigned. This complex consists of a surface-active lipid layer
Clements JA, Crouch E, deMello DE, Dirksen U, Doyle IR, Fisher JH, Floros J, Glasser SW, Green D, Hawgood S, Ikegami M, Ikegami M, Ikegami M, Kitamura T, Kresch MJ, Madan T, Mahut B, Mason RJ, Myrianthopoulos NC, Nogee LM, Pilot-Matias TJ, Power JHT, Prakash UBS, Reed JA, Robertson B, Rosen SH, Stoll BJ, Tredano M, Vorbroker DK, Wang J-Y   +29 more
core   +1 more source

A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

eLife, 2020
We establish a murine lung-on-chip infection model and use time-lapse imaging to reveal the dynamics of host-Mycobacterium tuberculosis interactions at an air-liquid interface with a spatiotemporal resolution unattainable in animal models and to probe ...
Vivek V Thacker, Neeraj Dhar, Kunal Sharma, Riccardo Barrile, Katia Karalis, John D McKinney   +5 more
doaj   +1 more source

Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response [PDF]

, 2014
Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue.
Floros, Joanna, López Barneo, José, Olmeda, Bárbara, Pascual Bravo, Alberto, Phelps, David S., Pérez Gil, Jesús, Silveyra, Patricia, Umstead, Todd M.   +7 more
core   +1 more source

The importance of surfactant on the development of neonatal pulmonary diseases Síndrome da angustia respiratória aguda e proteinose alveolar congênita

Clinics, 2007
Pulmonary surfactant is a substance composed of a lipoprotein complex that is essential to pulmonary function. Pulmonary surfactant proteins play an important role in the structure, function, and metabolism of surfactant; 4 specific surfactant proteins ...
Priscila Pinheiro Ribeiro Lyra, Edna Maria de Albuquerque Diniz   +1 more
doaj   +1 more source

Recent advances in understanding idiopathic pulmonary fibrosis [PDF]

, 2016
Despite major research efforts leading to the recent approval of pirfenidone and nintedanib, the dismal prognosis of idiopathic pulmonary fibrosis (IPF) remains unchanged.
Daccord, C, Maher, TM
core   +3 more sources