The role of miR-431-5p in regulating pulmonary surfactant expression in vitro
Cellular & Molecular Biology Letters, 2019 Background Pulmonary surfactant is the complex mixture of lipid and protein that covers the alveolar surface. Pulmonary surfactant deficiency is one of the main causes of neonatal respiratory distress.
Shujun Li +8 more
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Inhibition and counterinhibition of Surfacen, a clinical lung surfactant of natural origin. [PDF]
PLoS ONE, 2018 Inactivation of pulmonary surfactant by different components such as serum, cholesterol or meconium contributes to severe respiratory pathologies through destabilization and collapse of airspaces.
Yuliannis Lugones +5 more
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Pulmonary alveolar proteinosis, unusual infiltrative lung disease, the dilemma for physicians: A case report and literature review [PDF]
Journal of Analytical Research in Clinical Medicine, 2017 Introduction: Pulmonary alveolar proteinosis (PAP) is a diffuse pulmonary disease characterized by the intra-alveolar accumulation of formless, proteinaceous material.
Ali Ghavidel
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Computational and Structural Biotechnology Journal, 2022 Background: Acute respiratory distress syndrome (ARDS) could account for a considerable proportion of neonatal death, while the genetic etiology and pathophysiology of neonatal ARDS remain elusive.
Huiyao Chen +9 more
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Surfactant gene polymorphisms and interstitial lung diseases
Respiratory Research, 2001 Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function.
Pantelidis Panagiotis +2 more
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The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants [PDF]
, 2018 Inhaled nanoparticles traveling through the airways are able to reach the respiratory zone of the lungs. In such event, the incoming particles first enter in contact with the liquid lining the alveolar epithelium, the pulmonary surfactant.
Berret, J. -F., Mousseau, F.
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Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]
, 2019 Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn +7 more
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Multifunctional nanocarriers for lung drug delivery [PDF]
, 2020 Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical ...
Grenha, Ana, Pontes, Jorge Filipe
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The Inhibitory Effect of Curosurf® and Alveofact® on the Formation of Neutrophil Extracellular Traps
Frontiers in Immunology, 2021 BackgroundNeutrophil extracellular traps (NETs) are a defense mechanism in which neutrophils cast a net-like structure in response to microbial infection. NETs consist of decondensed chromatin and about 30 enzymes and peptides.
Annabell Schulz +8 more
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Frontiers in Physiology, 2023 Sigma1 receptor protein (Sigmar1) is a small, multifunctional molecular chaperone protein ubiquitously expressed in almost all body tissues. This protein has previously shown its cardioprotective roles in rodent models of cardiac hypertrophy, heart ...
Naznin Sultana Remex +13 more
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