Results 41 to 50 of about 40,759 (154)

Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis

Disease Models & Mechanisms, 2013
Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disease for which there is no known treatment. Although the traditional paradigm of IPF pathogenesis emphasized chronic inflammation as the primary driver of fibrotic remodeling ...
Jonathan A. Kropski, William E. Lawson, Lisa R. Young, Timothy S. Blackwell   +3 more
doaj   +1 more source

Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats [PDF]

, 2016
The increasing use of silver nanoparticles (AgNPs) in consumer products is concerning. We examined the potential toxic effects when inhaled in Brown-Norway (BN) rats with a pre-inflammatory state compared to Sprague-Dawley (SD) rats.We determined the ...
Buckley, A, Chung, KF, Dai, R, Gong, J, Gow, A, Guo, C, Hodgson, A, Hussain, F, Leo, B, Martin, NG, Porter, A, Ryan, M, Seiffert, J, Smith, R, Tetley, T, Warren, J, Zhang, J, Zhu, J   +17 more
core   +1 more source

Melting transitions in biomembranes

, 2019
We investigated melting transitions in biological membranes in their native state that include their membrane proteins. These membranes originated from \textit{E. coli}, \textit{B.
Heimburg, Thomas, Konrad, Manfred, Madsen, Soren B., Music, Tea, Pollakowski, Denis, Tounsi, Fatma   +5 more
core   +1 more source

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerols⃞

Journal of Lipid Research, 2007
The highly branched mammalian lung relies on surfactant, a mixture of phospholipids, cholesterol, and hydrophobic proteins, to reduce intraalveolar surface tension and prevent lung collapse.
Michael L. Fitzgerald, Ramnik Xavier, Kathleen J. Haley, Ruth Welti, Julie L. Goss, Cari E. Brown, Debbie Z. Zhuang, Susan A. Bell, Naifang Lu, Mary Mckee, Brian Seed, Mason W. Freeman   +11 more
doaj   +1 more source

Quantitative proteomics analysis of Angiostrongylus vasorum-induced alterations in dog serum sheds light on the pathogenesis of canine angiostrongylosis

Scientific Reports, 2021
Blood contains hundreds of proteins, reflecting ongoing cellular processes and immune reactions. Infections with the blood-dwelling cardiopulmonary nematode Angiostrongylus vasorum in dogs manifest with a broad spectrum of clinical signs including ...
Lucienne Tritten, Nina Gillis-Germitsch, Tobias Kockmann, Manuela Schnyder   +3 more
doaj   +1 more source

Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result. [PDF]

, 2015
In contrast to the probabilistic way of thinking about pleiotropy as the random expression of a single gene that generates two or more distinct phenotypic traits, it is actually a deterministic consequence of the evolution of complex physiology from the ...
Torday, John S
core   +2 more sources

Peri-intraventricular hemorrhage in premature newborns: associated with immediate umbilical cord clamping, vaginal delivery and surfactant use [PDF]

Revista Brasileira de Saúde Materno Infantil
Objectives: to determine the incidence of peri-intraventricular hemorrhage (PIVH) and the risk factors in newborns weighing
Danielle Albuquerque Sousa, Pedro Lucas de Morais Ferreira, Juliana Dantas de Araújo Santos Camargo, Sarah de Lima Alloufa da Silveira, Anna Christina do Nascimento Granjeiro Barreto   +4 more
doaj   +1 more source

The Common Haplotype GATGACA in Surfactant-Protein B Gene Is Protective for Respiratory Distress Syndrome in Preterm Neonates

Frontiers in Pediatrics, 2022
BackgroundRespiratory distress syndrome (RDS), a disorder of primary surfactant deficiency resulting in pulmonary insufficiency, remains a significant problem for preterm neonates. Associations between genetic variants of surfactant proteins and RDS have
Silvia Mikolajcikova, Zora Lasabova, Veronika Holubekova, Maria Skerenova, Jana Zibolenova, Katarina Matasova, Mirko Zibolen, Andrea Calkovska   +7 more
doaj   +1 more source

Fox Serum Proteomics Analysis Suggests Host-Specific Responses to Angiostrongylus vasorum Infection in Canids

Pathogens, 2021
Dogs infected with the cardiopulmonary nematode Angiostrongylus vasorum may suffer from respiratory distress and/or bleeding disorders. Descriptions of clinical signs in foxes are rare, despite high prevalence.
Nina Gillis-Germitsch, Tobias Kockmann, Christian M. O. Kapel, Stig M. Thamsborg, Pia Webster, Lucienne Tritten, Manuela Schnyder   +6 more
doaj   +1 more source

Mavrilimumab, a fully human granulocyte-macrophage colony-stimulating factor receptor α monoclonal antibody: long-term safety and efficacy in patients with rheumatoid arthritis [PDF]

, 2018
Objective: Mavrilimumab, a human monoclonal antibody, targets granulocyte-macrophage colony-stimulating factor receptor alpha. We report mavrilimumab long-term safety and efficacy in rheumatoid arthritis patients in two phase IIb studies (1071, 1107 ...
Achuthan, Akagawa, Aletaha, Aletaha, Antoniu, Avci, Berghen, Borg, Borie, Brown, Buch, Burmester, Burmester, Calisto, Cella, Chen, Cook, Cornish, Cottin, Crotti, Dawson, Felson, Fleetwood, Fries, Greven, Guo, Hamilton, Jaguin, Kelly, Khan, Lazaro, Listing, Minter, Prevoo, Shaw, Shibata, Singh, Tsuchiya, Van der Heijde, Van Gestel, Van Onna, Ware, Weinblatt, Yoshida, Zhan   +44 more
core   +1 more source