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The next frontier in lung development and regeneration research: harnessing iPSC models to illuminate notch signaling pathways [PDF]
Frontiers in Cell and Developmental BiologyThe respiratory system relies on a diverse repertoire of epithelial cell types to ensure efficient air conduction and gas exchange. This cellular heterogeneity arises through tightly coordinated intercellular signaling events that extend from embryonic ...
Yuetong Song +10 more
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Impact of E-Cigarettes on Fetal and Neonatal Lung Development: The Influence of Oxidative Stress and Inflammation [PDF]
AntioxidantsElectronic cigarettes (e-cigs) recently increased their popularity as “safer” alternatives to traditional tobacco smoking, including among pregnant women.
Antonella Gambadauro +5 more
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The impact of hormones on lung development and function: an overlooked aspect to consider from early childhood [PDF]
Frontiers in EndocrinologyThe impact of hormones on the respiratory system constitutes a multifaceted and intricate facet of human biology. We propose a comprehensive review of recent advancements in understanding the interactions between hormones and pulmonary development and ...
Gloria Pelizzo +11 more
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Nature Communications, 2022 Suppression of transcription in S-phase is crucial to prevent genome instability. Zhang et al demonstrate that increase of H4K20me1 due to loss of Kmt5b cause genome instability in muscle stem cells, resulting in stem cell senescence but rhabdomyosarcoma
Ting Zhang +7 more
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Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]
, 2013 Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Bermudez, Olga +4 more
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Nature Communications, 2022 The miR-1/133/206 gene family codes for the most abundant microRNAs in striated muscles. Here, Klockner et al show that inactivation of all family members in skeletal muscle prevents formation of normal neuromuscular junctions due to increased expression
Ina Klockner +4 more
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Cell and Tissue Research, 2017 To fulfill the task of gas exchange, the lung possesses a huge inner surface and a tree-like system of conducting airways ventilating the gas exchange area. During lung development, the conducting airways are formed first, followed by the formation and enlargement of the gas exchange area.
openaire +5 more sources
Nature Communications, 2022 Utrophin is a dystrophin-related protein stabilizing the sarcolemma in absence of dystrophin. Here the authors report that inactivation of the protein deacetylase SIRT6, involved in the deacetylation of the epigenetic mark H3K56ac in muscle cells ...
Angelina M. Georgieva +12 more
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Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling
Cells, 2022 The development of the embryonic lung demands complex endodermal–mesodermal interactions, which are regulated by a variety of signaling proteins. Hedgehog (Hh) signaling is vital for lung development.
Ling-Hui Zeng +12 more
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BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas. [PDF]
, 2015 BPTF, a subunit of NURF, is well known to be involved in the development of eukaryotic cell, but little is known about its roles in cancers, especially in non-small-cell lung cancer (NSCLC).
Dai, Meng +14 more
core +7 more sources