Results 1 to 10 of about 28,027 (244)

Postnatal hyperoxia exposure differentially affects hepatocytes and liver haemopoietic cells in newborn rats. [PDF]

PLoS ONE, 2014
Premature newborns are frequently exposed to hyperoxic conditions and experimental data indicate modulation of liver metabolism by hyperoxia in the first postnatal period.
Guya Diletta Marconi, Susi Zara, Marianna De Colli, Valentina Di Valerio, Monica Rapino, Patrizia Zaramella, Arben Dedja, Veronica Macchi, Raffaele De Caro, Andrea Porzionato   +9 more
doaj   +5 more sources

Anti-placental growth factor antibody ameliorates hyperoxia-mediated impairment of lung development in neonatal rats [PDF]

Brazilian Journal of Medical and Biological Research, 2020
This study investigates the effect of the overexpression of the placental growth factor (PGF) and hyperoxia on lung development and determines whether anti-PGF antibody ameliorates hyperoxia-mediated impairment of lung development in newborn rats.
Zhiqun Zhang, Ying Zhong, Xiaoxia Li, Xianmei Huang, Lizhong Du   +4 more
doaj   +2 more sources

Prenatal Maternal Lipopolysaccharide and Mild Newborn Hyperoxia Increase Intrapulmonary Airway but Not Vessel Reactivity in a Mouse Model

Children, 2021
Maternal infection is a risk for preterm delivery. Preterm newborns often require supplemental oxygen to treat neonatal respiratory distress. Newborn hyperoxia exposure is associated with airway and vascular hyperreactivity, while the complications of ...
Margaret E. Kuper-Sassé, Peter M. MacFarlane, Catherine A. Mayer, Richard J. Martin, Y. S. Prakash, Christina M. Pabelick, Thomas M. Raffay   +6 more
doaj   +1 more source

Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells

Respiratory Research, 2022
Background Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization.
Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. Huntington, Monique E. De Paepe, Phyllis A. Dennery   +5 more
doaj   +1 more source

Functional metagenomic and metabolomics analysis of gut dysbiosis induced by hyperoxia

Frontiers in Microbiology, 2023
BackgroundInhaled oxygen is the first-line therapeutic approach for maintaining tissue oxygenation in critically ill patients, but usually exposes patients to damaging hyperoxia.
Yulan Cai, Yulan Cai, Yulan Cai, Yanhong Luo, Ninan Dai, Yan Yang, Yan Yang, Ying He, Huajun Chen, Manlu Zhao, Xiaoyun Fu, Tao Chen, Zhouxiong Xing   +12 more
doaj   +1 more source

Calcium-Sensing Receptor Contributes to Hyperoxia Effects on Human Fetal Airway Smooth Muscle

Frontiers in Physiology, 2021
Supplemental O2 (hyperoxia), necessary for maintenance of oxygenation in premature infants, contributes to neonatal and pediatric airway diseases including asthma.
Anne M. Roesler, Jovanka Ravix, Colleen M. Bartman, Brijeshkumar S. Patel, Marta Schiliro, Benjamin Roos, Lisa Nesbitt, Christina M. Pabelick, Christina M. Pabelick, Richard J. Martin, Peter M. MacFarlane, Y. S. Prakash, Y. S. Prakash   +12 more
doaj   +1 more source

Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men [PDF]

Brazilian Journal of Medical and Biological Research, 2022
In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 ...
V.P. Garcia, J.D. Mattos, J. Mentzinger, P.E.C. Leite, H.N.M. Rocha, M.O. Campos, M.P. Rocha, D.E. Mansur, N.H. Secher, A.C.L. Nóbrega, I.A. Fernandes, N.G. Rocha   +11 more
doaj   +1 more source

Hyperoxia decreases glycolytic capacity, glycolytic reserve and oxidative phosphorylation in MLE-12 cells and inhibits complex I and II function, but not complex IV in isolated mouse lung mitochondria.

PLoS ONE, 2013
High levels of oxygen (hyperoxia) are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants.
Kumuda C Das
doaj   +1 more source

Aspirin Attenuates Hyperoxia-Induced Acute Respiratory Distress Syndrome (ARDS) by Suppressing Pulmonary Inflammation via the NF-κB Signaling Pathway

Frontiers in Pharmacology, 2022
Acute respiratory distress syndrome (ARDS) is a common destructive syndrome with high morbidity and mortality rates. Currently, few effective therapeutic interventions for ARDS are available.
Yu-Tang Tung, Yu-Tang Tung, Yu-Tang Tung, Yu-Tang Tung, Chi-Hsuan Wei, Chi-Hsuan Wei, Chih-Ching Yen, Po-Ying Lee, Lorraine B. Ware, Hao-En Huang, Wei Chen, Chuan-Mu Chen, Chuan-Mu Chen, Chuan-Mu Chen   +13 more
doaj   +1 more source

Treatment of Hyperoxia-Induced Lung Injury with Lung Mesenchymal Stem Cells in Mice

Stem Cells International, 2018
Objective. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm neonates and has no effective treatment. This study aimed to investigate the therapeutic effects of neonatal mouse lung resident mesenchymal stem cells (L-MSCs) on ...
Yabo Mei, Chong Chen, Hui Dong, Wanqiao Zhang, Yan Wang, Ming Chi, Zhichun Feng   +6 more
doaj   +1 more source