Results 1 to 10 of about 41,556 (244)

Neonatal hyperoxia exposure causes cerebellar lesions and behavioral abnormalities in rats [PDF]

Scientific Reports
In humans, fetal cerebellar development peaks during the final stages of pregnancy. Preterm infants experience hyperoxia (excessive oxygen) outside the uterus. Hyperoxia exposure causes neurological deficits in preterm infants.
Sakiko Suzuki, Takahiro Kanzawa, Ryoko Shimode, Yukina Takamoto, Kazuto Ueda, Ryosuke Miura, Toshihiko Suzuki, Naoki Tajiri, Hideki Hida, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki Sato   +11 more
doaj   +2 more sources

Impact of early hyperoxia on outcomes during neonatal and pediatric veno-arterial extracorporeal life support★ [PDF]

The Journal of ExtraCorporeal Technology
Background: Hyperoxia induces oxidative stress and can exacerbate inflammatory response to Veno-Arterial Extracorporeal Life Support (VA–ECLS). This study aimed to evaluate the association between hyperoxia during VA–ECLS and morbidity, complications ...
Saini Ashish, Shamah Rebecca, Qian Joshua, Keane-Lerner Kasey, Morales Paola Rodriguez, Nayi Pranay, Shyam Adithi, Davis Joel, John Mohan, Viamonte Heather, Beshish Assad G   +10 more
doaj   +2 more sources

Effects of hyperoxia in pediatric perfusion patients: a scoping review [PDF]

The Journal of ExtraCorporeal Technology
Hyperoxia in pediatric cardiopulmonary bypass patients is associated with adverse effects, including reoxygenation injury, increased mortality, heightened inflammatory response, and cerebral injury.
DeRenzo Mariah, Velazquez-Milton Vanessa, Johnson Stepney   +2 more
doaj   +2 more sources

TXNIP mediates ferroptosis in a bronchopulmonary dysplasia mouse model by regulating the SLC7A11/GPX4 pathway [PDF]

Scientific Reports
Bronchopulmonary dysplasia (BPD) is one of the most common respiratory diseases in preterm infants. Studies have shown that ferroptosis is involved in the pathogenesis of BPD, and thioredoxin-interacting protein (TXNIP)-mediated oxidative stress also ...
Dongzhui Chen, Feifei Yin, Pin Yang, Wanrong Xia, Yi Huang, Yue Feng, Li Yang, Shuqiang Lin, Qiuyue Zhang   +8 more
doaj   +2 more sources

Prenatal Maternal Lipopolysaccharide and Mild Newborn Hyperoxia Increase Intrapulmonary Airway but Not Vessel Reactivity in a Mouse Model

Children, 2021
Maternal infection is a risk for preterm delivery. Preterm newborns often require supplemental oxygen to treat neonatal respiratory distress. Newborn hyperoxia exposure is associated with airway and vascular hyperreactivity, while the complications of ...
Margaret E. Kuper-Sassé, Peter M. MacFarlane, Catherine A. Mayer, Richard J. Martin, Y. S. Prakash, Christina M. Pabelick, Thomas M. Raffay   +6 more
doaj   +1 more source

Postnatal hyperoxia exposure differentially affects hepatocytes and liver haemopoietic cells in newborn rats. [PDF]

PLoS ONE, 2014
Premature newborns are frequently exposed to hyperoxic conditions and experimental data indicate modulation of liver metabolism by hyperoxia in the first postnatal period.
Guya Diletta Marconi, Susi Zara, Marianna De Colli, Valentina Di Valerio, Monica Rapino, Patrizia Zaramella, Arben Dedja, Veronica Macchi, Raffaele De Caro, Andrea Porzionato   +9 more
doaj   +1 more source

Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells

Respiratory Research, 2022
Background Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization.
Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. Huntington, Monique E. De Paepe, Phyllis A. Dennery   +5 more
doaj   +1 more source

Calcium-Sensing Receptor Contributes to Hyperoxia Effects on Human Fetal Airway Smooth Muscle

Frontiers in Physiology, 2021
Supplemental O2 (hyperoxia), necessary for maintenance of oxygenation in premature infants, contributes to neonatal and pediatric airway diseases including asthma.
Anne M. Roesler, Jovanka Ravix, Colleen M. Bartman, Brijeshkumar S. Patel, Marta Schiliro, Benjamin Roos, Lisa Nesbitt, Christina M. Pabelick, Christina M. Pabelick, Richard J. Martin, Peter M. MacFarlane, Y. S. Prakash, Y. S. Prakash   +12 more
doaj   +1 more source

Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men [PDF]

Brazilian Journal of Medical and Biological Research, 2022
In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 ...
V.P. Garcia, J.D. Mattos, J. Mentzinger, P.E.C. Leite, H.N.M. Rocha, M.O. Campos, M.P. Rocha, D.E. Mansur, N.H. Secher, A.C.L. Nóbrega, I.A. Fernandes, N.G. Rocha   +11 more
doaj   +1 more source

Functional metagenomic and metabolomics analysis of gut dysbiosis induced by hyperoxia

Frontiers in Microbiology, 2023
BackgroundInhaled oxygen is the first-line therapeutic approach for maintaining tissue oxygenation in critically ill patients, but usually exposes patients to damaging hyperoxia.
Yulan Cai, Yulan Cai, Yulan Cai, Yanhong Luo, Ninan Dai, Yan Yang, Yan Yang, Ying He, Huajun Chen, Manlu Zhao, Xiaoyun Fu, Tao Chen, Zhouxiong Xing   +12 more
doaj   +1 more source