Results 11 to 20 of about 19,463 (207)
Critical Care, 2021 AbstractOxygen (O2) toxicity remains a concern, particularly to the lung. This is mainly related to excessive production of reactive oxygen species (ROS).Supplemental O2, i.e. inspiratory O2concentrations (FIO2) > 0.21 may causehyperoxaemia(i.e. arterial (a) PO2 > 100 mmHg) and, subsequently,hyperoxia(increased tissue O2concentration), thereby ...
Mervyn Singer +7 more
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European Psychiatry, 2021 Introduction Several studies of normobaric hyperoxia in some neurological conditions have demonstrated clinical benefits. Oxygen enriched air may increase oxygen pressure in brain tissue and have biochemical effects such as on brain erythropoietin gene expression, even in patients without lung disease.
R. Belmaker +5 more
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Hyperoxia and the Immature Brain [PDF]
Developmental Neuroscience, 2016 Despite major advances in obstetrics and neonatal intensive care, preterm infants frequently suffer from neurological impairments in later life. Preterm and also full-term neonates are generally susceptible to injury caused by reactive oxygen species due to the immaturity of endogenous radical scavenging systems.
Reich, Bettina +3 more
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Hyperoxia in Extreme Hemodilution [PDF]
European Surgical Research, 2002 Intraoperative surgical blood loss is initially replaced by infusion of red cell-free, cristalloidal or colloidal solutions. When normovolemia is maintained the ensuing dilutional anemia is compensated by an increase of cardiac output and of arterial oxygen extraction.
Habler, Oliver +3 more
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Experimental Biology and Medicine, 1973 SummaryExposure to a 50% oxygen environment produced a decrease in erythropoiesis which was paralleled by a decrease in plasma erythropoietic stimulating activity. Similar results were obtained following exposure to a 100% oxygen environment. Marrow depression produced by hyperoxia could be reversed by erythropoietic stimulants.
J W, Fletcher +3 more
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Hyperoxia Induced Hypomyelination
Biomedicines, 2022 We asked whether hyperoxia might induce hypomyelination of the corpus callosum, clinically described as periventricular leukomalacia (PVL) of the severely preterm infant. Mouse pups and their nursing dams were placed in 80% oxygen from P4-P8, then removed to room air until P11.
Weilin Song +4 more
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Frontiers in Pharmacology, 2022 Acute respiratory distress syndrome (ARDS) is a common destructive syndrome with high morbidity and mortality rates. Currently, few effective therapeutic interventions for ARDS are available.
Yu-Tang Tung +13 more
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Treatment of Hyperoxia-Induced Lung Injury with Lung Mesenchymal Stem Cells in Mice
Stem Cells International, 2018 Objective. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm neonates and has no effective treatment. This study aimed to investigate the therapeutic effects of neonatal mouse lung resident mesenchymal stem cells (L-MSCs) on ...
Yabo Mei +6 more
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PLoS ONE, 2013 High levels of oxygen (hyperoxia) are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants.
Kumuda C Das
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Redox Biology, 2023 Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role.
Sandra L. Grimm +9 more
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