Results 21 to 30 of about 41,556 (244)

670 nm light mitigates oxygen-induced degeneration in C57BL/6J mouse retina [PDF]

, 2016
BACKGROUND Irradiation with light wavelengths from the far red (FR) to the near infrared (NIR) spectrum (600 nm -1000 nm) has been shown to have beneficial effects in several disease models.
Albarracin, Rizalyn, Natoli, Riccardo, Provis, Jan, Rutar, Matthew, Valter, Krisztina   +4 more
core   +1 more source

Aspirin Attenuates Hyperoxia-Induced Acute Respiratory Distress Syndrome (ARDS) by Suppressing Pulmonary Inflammation via the NF-κB Signaling Pathway

Frontiers in Pharmacology, 2022
Acute respiratory distress syndrome (ARDS) is a common destructive syndrome with high morbidity and mortality rates. Currently, few effective therapeutic interventions for ARDS are available.
Yu-Tang Tung, Yu-Tang Tung, Yu-Tang Tung, Yu-Tang Tung, Chi-Hsuan Wei, Chi-Hsuan Wei, Chih-Ching Yen, Po-Ying Lee, Lorraine B. Ware, Hao-En Huang, Wei Chen, Chuan-Mu Chen, Chuan-Mu Chen, Chuan-Mu Chen   +13 more
doaj   +1 more source

MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]

, 2016
PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet, Avni, Reut, Biton, Inbal, Cohen, Yonni, Garbow, Joel R, Golani, Ofra, Neeman, Michael   +6 more
core   +2 more sources

Treatment of Hyperoxia-Induced Lung Injury with Lung Mesenchymal Stem Cells in Mice

Stem Cells International, 2018
Objective. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm neonates and has no effective treatment. This study aimed to investigate the therapeutic effects of neonatal mouse lung resident mesenchymal stem cells (L-MSCs) on ...
Yabo Mei, Chong Chen, Hui Dong, Wanqiao Zhang, Yan Wang, Ming Chi, Zhichun Feng   +6 more
doaj   +1 more source

Hyperoxia decreases glycolytic capacity, glycolytic reserve and oxidative phosphorylation in MLE-12 cells and inhibits complex I and II function, but not complex IV in isolated mouse lung mitochondria.

PLoS ONE, 2013
High levels of oxygen (hyperoxia) are frequently used in critical care units and in conditions of respiratory insufficiencies in adults, as well as in infants.
Kumuda C Das
doaj   +1 more source

Umbilical cord blood–derived exosomes from healthy term pregnancies protect against hyperoxia‐induced lung injury in mice

Clinical and Translational Science, 2023
Bronchopulmonary dysplasia (BPD) is a chronic, devastating disease primarily occurring in premature infants. To date, intervention strategies to prevent or treat BPD are limited. We aimed to determine the effects of umbilical cord blood‐derived exosomes (
Xin‐qi Zhong, Ding Wang, Shuang Chen, Jing Zheng, Tao‐fang Hao, Xiu‐hong Li, Li‐hua Luo, Jian Gu, Chang‐yu Lian, Xiao‐sa Li, Dun‐jin Chen   +10 more
doaj   +1 more source

Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation

Redox Biology, 2023
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role.
Sandra L. Grimm, Rachel E. Stading, Matthew J. Robertson, Tanmay Gandhi, Chenlian Fu, Weiwu Jiang, Guobin Xia, Krithika Lingappan, Cristian Coarfa, Bhagavatula Moorthy   +9 more
doaj   +1 more source

Distribution of Capillary Transit Times in Isolated Lungs of Oxygen-Tolerant Rats [PDF]

, 2010
Rats pre-exposed to 85% O2 for 5–7 days tolerate the otherwise lethal effects of 100% O2. The objective was to evaluate the effect of rat exposure to 85% O2 for 7 days on lung capillary mean transit time (t¯c) and distribution of capillary transit times (
AB Fisher, AB Fisher, AJ Schwab, Anne V. Clough, AV Clough, BA Freeman, BA Freeman, CA Dawson, CA Goresky, D Jamieson, David L. Roerig, DJ Kwak, E Cadenas, G Capellier, G Lenaz, JB Bassingthwaighte, JD Crapo, JD Crapo, JD Crapo, JE Heffner, JF Turrens, JM Gonzalez-Fernandez, K Howell, K Sjostrom, KH Albrecht, L Frank, Madhavi Ramakrishna, ML Zierhut, MP Merker, MP Merker, NC Staub, OD Saugstad, R Beasley, RD Bongard, RD Bongard, RE Kimball, RG Presson Jr, RG Presson Jr, Robert C. Molthen, RR Mercer, S Valenca Sdos, Said H. Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Audi, SH Randell, V Bhandari, V Kim, W Shi, WG Guntheroth, WS Miller, YS Ho, Zhuohui Gan   +59 more
core   +2 more sources

Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model [PDF]

, 2011
Accurate imaging of the ischemic penumbra is a prerequisite for acute clinical stroke research. T2* magnetic resonance imaging (MRI) combined with an oxygen challenge (OC) is being developed to detect penumbra based on changes in blood deoxyhemoglobin ...
Baskerville, Tracey, Deuchar, Graeme A., Holmes, William M., Macrae, I. Mhairi, McCabe, Chris, Robertson, Craig A., Santosh, Celestine   +6 more
core   +1 more source

Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery

Acta Medica Lituanica, 2017
Background. Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent evidence suggest that it might have multiple detrimental effects on patient homeostasis.
Gabrielius Jakutis, Ieva Norkienė, Donata Ringaitienė, Tomas Jovaiša   +3 more
doaj   +1 more source