Results 21 to 30 of about 19,463 (207)

GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice

Journal of Neuroinflammation, 2023
Background Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’s inflammasome pathway, leading to
Naga Venkata Divya Challa, Shaoyi Chen, Huijun Yuan, Matthew R. Duncan, William Javier Moreno, Helen Bramlett, W. Dalton Dietrich, Merline Benny, Augusto F. Schmidt, Karen Young, Shu Wu   +10 more
doaj   +1 more source

Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery

Acta Medica Lituanica, 2017
Background. Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent evidence suggest that it might have multiple detrimental effects on patient homeostasis.
Gabrielius Jakutis, Ieva Norkienė, Donata Ringaitienė, Tomas Jovaiša   +3 more
doaj   +1 more source

Umbilical cord blood–derived exosomes from healthy term pregnancies protect against hyperoxia‐induced lung injury in mice

Clinical and Translational Science, 2023
Bronchopulmonary dysplasia (BPD) is a chronic, devastating disease primarily occurring in premature infants. To date, intervention strategies to prevent or treat BPD are limited. We aimed to determine the effects of umbilical cord blood‐derived exosomes (
Xin‐qi Zhong, Ding Wang, Shuang Chen, Jing Zheng, Tao‐fang Hao, Xiu‐hong Li, Li‐hua Luo, Jian Gu, Chang‐yu Lian, Xiao‐sa Li, Dun‐jin Chen   +10 more
doaj   +1 more source

Curcumin analogs (B2BrBC and C66) supplementation attenuates airway hyperreactivity and promote airway relaxation in neonatal rats exposed to hyperoxia

Physiological Reports, 2020
Background This study was undertaken to test the hypothesis that the newly synthesized curcuminoids B2BrBC and C66 supplementation will overcome hyperoxia‐induced tracheal hyperreactivity and impairment of relaxation of tracheal smooth muscle (TSM ...
Mimoza Stamenkovska, Qendrim Thaçi, Nikola Hadzi‐Petrushev, Marija Angelovski, Jane Bogdanov, Shkëlzen Reçica, Islam Kryeziu, Hristo Gagov, Vadim Mitrokhin, Andre Kamkin, Rudolf Schubert, Mitko Mladenov, Ramadan B. Sopi   +12 more
doaj   +1 more source

Bone mesenchymal stem cell-derived exosomes prevent hyperoxia-induced apoptosis of primary type II alveolar epithelial cells in vitro [PDF]

PeerJ, 2022
Background The presence of alveolar epithelial type II cells (AECIIs) is one of the most important causes of bronchopulmonary dysplasia (BPD). Exosomes from bone mesenchymal stem cells (BMSCs) can reduce hyperoxia-induced damage and provide better ...
Wei Yang, Chao Huang, Wenjian Wang, Baozhu Zhang, Yunbin Chen, Xinlin Xie   +5 more
doaj   +2 more sources

Hyperoxia in acute asthma [PDF]

Thorax, 2011
We read with interest the recent article ‘Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma’ by Perrin et al 1 and the accompanying editorial. We note that data presented in the online supplement suggest, unsurprisingly, response to treatment at 60 min in terms of respiratory rate and ...
Catherine, Snelson, Bill, Tunnicliffe
openaire   +2 more sources

The pentose phosphate pathway mediates hyperoxia-induced lung vascular dysgenesis and alveolar simplification in neonates

JCI Insight, 2021
Dysmorphic pulmonary vascular growth and abnormal endothelial cell (EC) proliferation are paradoxically observed in premature infants with bronchopulmonary dysplasia (BPD), despite vascular pruning.
Jiannan Gong, Zihang Feng, Abigail L. Peterson, Jennifer F. Carr, Xuexin Lu, Haifeng Zhao, Xiangming Ji, You-Yang Zhao, Monique E. De Paepe, Phyllis A. Dennery, Hongwei Yao   +10 more
doaj   +1 more source

Postnatal hyperoxia or DEHP exposure leads to growth restriction and delayed lung development in newborn rats

Pediatrics and Neonatology, 2018
Background: Di-(2-ethylhexyl) phthalate (DEHP) is commonly used as a plasticizer in many medical devices. We previously showed that maternal DEHP exposure led to restricted growth and delayed lung maturation in newborn rats.
Zhong-Jie Liang, Qiu-Ping Wu, Bei-Tao Chen, Zhen-lang Lin, Jing Lin, Shang-Qin Chen   +5 more
doaj   +1 more source

Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury

Respiratory Research, 2022
Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating evidence supports the vascular hypothesis of BPD, in which lung endothelial cell dysfunction drives this ...
Jason L. Chang, Jiannan Gong, Salu Rizal, Abigail L. Peterson, Julia Chang, Chenrui Yao, Phyllis A. Dennery, Hongwei Yao   +7 more
doaj   +1 more source

Heat shock protein 70 protects the lungs from hyperoxic injury in a neonatal rat model of bronchopulmonary dysplasia.

PLoS ONE, 2023
Hyperoxia plays a significant role in the pathogenesis of lung injury, such as bronchopulmonary dysplasia (BPD), in premature infants or newborns. BPD management aims to minimize further injury, provide an optimal environment to support growth and ...
Cheng-Han Lee, Tzu-Cheng Su, Ming-Sheng Lee, Chien-Sheng Hsu, Rei-Cheng Yang, Jun-Kai Kao   +5 more
doaj   +1 more source