Results 21 to 30 of about 28,027 (244)

Oxygen toxicity: cellular mechanisms in normobaric hyperoxia [PDF]

, 2022
In clinical settings, oxygen therapy is administered to preterm neonates and to adults with acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest, carbon monoxide poisoning, and acute heart failure.
Baiton, Adam, Jaimon, Alvin, Lazaran, Lucas, Obioru, Dede, Alva, Ricardo, Stuart, Jeffrey A., Mirza, Maha, Samokysh, Lyuda, Al Makhoul, Tala, Cowan, Cale, Lazuran, Lucas, Bobinski, Ava   +11 more
core   +1 more source

Erythropoiesis and Hyperoxia

Experimental Biology and Medicine, 1973
SummaryExposure to a 50% oxygen environment produced a decrease in erythropoiesis which was paralleled by a decrease in plasma erythropoietic stimulating activity. Similar results were obtained following exposure to a 100% oxygen environment. Marrow depression produced by hyperoxia could be reversed by erythropoietic stimulants.
J W, Fletcher, N I, Gallagher, M A, Warnecke, R M, Donati   +3 more
openaire   +2 more sources

Hyperoxia Induced Hypomyelination

Biomedicines, 2022
We asked whether hyperoxia might induce hypomyelination of the corpus callosum, clinically described as periventricular leukomalacia (PVL) of the severely preterm infant. Mouse pups and their nursing dams were placed in 80% oxygen from P4-P8, then removed to room air until P11.
Weilin Song, George Hoppe, Demiana Hanna, Tara M. DeSilva, Jonathan E. Sears   +4 more
openaire   +3 more sources

Umbilical cord blood–derived exosomes from healthy term pregnancies protect against hyperoxia‐induced lung injury in mice

Clinical and Translational Science, 2023
Bronchopulmonary dysplasia (BPD) is a chronic, devastating disease primarily occurring in premature infants. To date, intervention strategies to prevent or treat BPD are limited. We aimed to determine the effects of umbilical cord blood‐derived exosomes (
Xin‐qi Zhong, Ding Wang, Shuang Chen, Jing Zheng, Tao‐fang Hao, Xiu‐hong Li, Li‐hua Luo, Jian Gu, Chang‐yu Lian, Xiao‐sa Li, Dun‐jin Chen   +10 more
doaj   +1 more source

Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation

Redox Biology, 2023
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role.
Sandra L. Grimm, Rachel E. Stading, Matthew J. Robertson, Tanmay Gandhi, Chenlian Fu, Weiwu Jiang, Guobin Xia, Krithika Lingappan, Cristian Coarfa, Bhagavatula Moorthy   +9 more
doaj   +1 more source

Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery

Acta Medica Lituanica, 2017
Background. Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent evidence suggest that it might have multiple detrimental effects on patient homeostasis.
Gabrielius Jakutis, Ieva Norkienė, Donata Ringaitienė, Tomas Jovaiša   +3 more
doaj   +1 more source

GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice

Journal of Neuroinflammation, 2023
Background Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’s inflammasome pathway, leading to
Naga Venkata Divya Challa, Shaoyi Chen, Huijun Yuan, Matthew R. Duncan, William Javier Moreno, Helen Bramlett, W. Dalton Dietrich, Merline Benny, Augusto F. Schmidt, Karen Young, Shu Wu   +10 more
doaj   +1 more source

Bone mesenchymal stem cell-derived exosomes prevent hyperoxia-induced apoptosis of primary type II alveolar epithelial cells in vitro [PDF]

PeerJ, 2022
Background The presence of alveolar epithelial type II cells (AECIIs) is one of the most important causes of bronchopulmonary dysplasia (BPD). Exosomes from bone mesenchymal stem cells (BMSCs) can reduce hyperoxia-induced damage and provide better ...
Wei Yang, Chao Huang, Wenjian Wang, Baozhu Zhang, Yunbin Chen, Xinlin Xie   +5 more
doaj   +2 more sources

Curcumin analogs (B2BrBC and C66) supplementation attenuates airway hyperreactivity and promote airway relaxation in neonatal rats exposed to hyperoxia

Physiological Reports, 2020
Background This study was undertaken to test the hypothesis that the newly synthesized curcuminoids B2BrBC and C66 supplementation will overcome hyperoxia‐induced tracheal hyperreactivity and impairment of relaxation of tracheal smooth muscle (TSM ...
Mimoza Stamenkovska, Qendrim Thaçi, Nikola Hadzi‐Petrushev, Marija Angelovski, Jane Bogdanov, Shkëlzen Reçica, Islam Kryeziu, Hristo Gagov, Vadim Mitrokhin, Andre Kamkin, Rudolf Schubert, Mitko Mladenov, Ramadan B. Sopi   +12 more
doaj   +1 more source

The pentose phosphate pathway mediates hyperoxia-induced lung vascular dysgenesis and alveolar simplification in neonates

JCI Insight, 2021
Dysmorphic pulmonary vascular growth and abnormal endothelial cell (EC) proliferation are paradoxically observed in premature infants with bronchopulmonary dysplasia (BPD), despite vascular pruning.
Jiannan Gong, Zihang Feng, Abigail L. Peterson, Jennifer F. Carr, Xuexin Lu, Haifeng Zhao, Xiangming Ji, You-Yang Zhao, Monique E. De Paepe, Phyllis A. Dennery, Hongwei Yao   +10 more
doaj   +1 more source