GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice
Journal of Neuroinflammation, 2023 Background Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’s inflammasome pathway, leading to
Naga Venkata Divya Challa +10 more
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Bone mesenchymal stem cell-derived exosomes prevent hyperoxia-induced apoptosis of primary type II alveolar epithelial cells in vitro [PDF]
PeerJ, 2022 Background The presence of alveolar epithelial type II cells (AECIIs) is one of the most important causes of bronchopulmonary dysplasia (BPD). Exosomes from bone mesenchymal stem cells (BMSCs) can reduce hyperoxia-induced damage and provide better ...
Wei Yang +5 more
doaj +2 more sources
Physiological Reports, 2020 Background This study was undertaken to test the hypothesis that the newly synthesized curcuminoids B2BrBC and C66 supplementation will overcome hyperoxia‐induced tracheal hyperreactivity and impairment of relaxation of tracheal smooth muscle (TSM ...
Mimoza Stamenkovska +12 more
doaj +1 more source
To DGC or not to DGC: oxygen guarding in the termite Zootermopsis nevadensis (Isoptera: Termopsidae) [PDF]
, 2005 The ability of some insects to engage in complex orchestrations of tracheal gas exchange has been well demonstrated, but its evolutionary origin remains obscure.
Lighton, John R. B. +1 more
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Hyperoxia in acute asthma [PDF]
Thorax, 2011 We read with interest the recent article ‘Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma’ by Perrin et al 1 and the accompanying editorial. We note that data presented in the online supplement suggest, unsurprisingly, response to treatment at 60 min in terms of respiratory rate and ...
Catherine, Snelson, Bill, Tunnicliffe
openaire +2 more sources
Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents [PDF]
, 2014 During dynamic exercise, mechanisms controlling the cardiovascular apparatus operate to provide adequate oxygen to fulfill metabolic demand of exercising muscles and to guarantee metabolic end-products washout.
Crisafulli, A +5 more
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Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea A Broadband NIRS Study [PDF]
, 2011 Using broadband near-infrared spectroscopy (NIRS) and cerebral micro-dialysis (MD), we investigated cerebral cellular metabolism and mitochondrial redox states, following hypercapnoea in 6 patients with traumatic brain injury (TBI).
Elwell, CE +6 more
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BMC Anesthesiology, 2018 Background Ketamine and hyperoxia are widely used in obstetric and pediatric settings. Either ketamine or hyperoxia has been reported to cause neuroapoptosis in the developing brain, and ketamine-induced neuronal apoptosis may involve a compensatory ...
Changyi Wu +3 more
doaj +1 more source
JCI Insight, 2021 Dysmorphic pulmonary vascular growth and abnormal endothelial cell (EC) proliferation are paradoxically observed in premature infants with bronchopulmonary dysplasia (BPD), despite vascular pruning.
Jiannan Gong +10 more
doaj +1 more source
Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra [PDF]
, 2008 We describe a novel magnetic resonance imaging technique for detecting metabolism indirectly through changes in oxyhemoglobin:deoxyhemoglobin ratios and T2* signal change during ‘oxygen challenge’ (OC, 5 mins 100% O2). During OC, T2* increase reflects O2
Barrie Condon +14 more
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