Results 41 to 50 of about 28,027 (244)

Riociguat prevents hyperoxia-impaired alveolarization.

, 2018
(A) H & E stained lung histology. Hyperoxia exposure in the presence of placebo decreased radial alveolar count (RAC) (B) and increased mean linear intercept (MLI) (C) as compared with normoxia. Administration of riociguat increased RAC and decreased MLI
Ronald Zambrano (5497406), Younghye Moon (200726), Shu Wu (492135), Shihua Luo (5497415), Yong Bao (296790), Luqing Wang (5257895), Merline Benny (5497403), Justin Percival (5497412), Ling Qin (68169), Fredrick Dapaah-Siakwan (5497409), Matthew R. Duncan (5497421), Keyur Donda (5497400), Karen Young (833929), Ruben Vaidya (5497418)   +13 more
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The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Antioxidants, 2021
Supplemental oxygen therapy with supraphysiological concentrations of oxygen (hyperoxia; >21% O2) is a life-saving intervention for patients experiencing respiratory distress.
Alex G. Gauthier, Jiaqi Wu, Mosi Lin, Ravikumar Sitapara, Abhijit Kulkarni, Ganesh A. Thakur, Edward E. Schmidt, Jeanette C. Perron, Charles R. Ashby, Lin L. Mantell   +9 more
doaj   +1 more source

Riociguat reduces hyperoxia-induced PH.

, 2018
(A) Right ventricular systolic pressure (RVSP) was significantly increased in the hyperoxia + placebo treated group as compared with normoxia group. Riociguat administration significantly decreased RVSP during hyperoxia.
Ronald Zambrano (5497406), Younghye Moon (200726), Shu Wu (492135), Shihua Luo (5497415), Yong Bao (296790), Luqing Wang (5257895), Merline Benny (5497403), Justin Percival (5497412), Ling Qin (68169), Fredrick Dapaah-Siakwan (5497409), Matthew R. Duncan (5497421), Keyur Donda (5497400), Karen Young (833929), Ruben Vaidya (5497418)   +13 more
core   +1 more source

Mechanism‐Informed Language Modeling and Oxygenated 3D Screening Identify Berberine–Enzalutamide Synergy in Prostate Cancer Models

Advanced Science, EarlyView.
By integrating knowledge‐augmented artificial intelligence with an oxygen‐supplemented 3D screening platform, a synergistic interaction between berberine and enzalutamide is identified. The framework integrates compound mechanisms of action with disease‐relevant signaling context to prioritize candidate combinations and generate testable pathway‐based ...
Chih‐Hui Lo, Katie Shi, Lina Kafadarian, Alexandra Bermudez, Johnny Diaz, Liam Edwards, Yunqi Hong, Ziyi Chen, Hyeonji Hwang, Weihong Yan, Alan Levinson, Robert Damoiseaux, Cho‐Jui Hsieh, Tanya Stoyanova, Andrew S. Goldstein, Neil Y.C. Lin   +15 more
wiley   +1 more source

Riociguat decreases hyperoxia-induced vascular remodeling.

, 2018
(A, C) Double immunofluorescence staining for vWF (green signal) and α-SMA (red signal) plus DAPI nuclear stain (blue signal). (B) Hyperoxia exposure in the presence of placebo increased muscularization of peripheral pulmonary vessels (D) Hyperoxia ...
Ronald Zambrano (5497406), Younghye Moon (200726), Shu Wu (492135), Shihua Luo (5497415), Yong Bao (296790), Luqing Wang (5257895), Merline Benny (5497403), Justin Percival (5497412), Ling Qin (68169), Fredrick Dapaah-Siakwan (5497409), Matthew R. Duncan (5497421), Keyur Donda (5497400), Karen Young (833929), Ruben Vaidya (5497418)   +13 more
core   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Protective effect of recombinant interleukin-10 on newborn rat lungs exposed to short-term sublethal hyperoxia [PDF]

Clinical and Experimental Pediatrics
Background Lung injury imposed by hyperoxia is the main cause of bronchopulmonary dysplasia in newborns. These injuries are generated from the early stage of hyperoxia through the main biologic effects of cell death and inflammatory response. Interleukin
Hyeon-Soo Lee, Young-Joon Ryu, Min-Jae Lee   +2 more
doaj   +1 more source

Hemodynamic Effects of Prolonged Apneic Oxygenation in Laryngologic Surgery: A Randomized Controlled Pilot Trial

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Limited data exist on cardiocirculatory responses associated with extended periods of apnea during administration of high‐flow nasal oxygen for laryngologic surgery (apneic oxygenation with HFNO, AO‐HFNO). The possibility of hemodynamic compromise in the settings of acute hypercapnia, respiratory acidosis, hyperoxia, and IV ...
Vladimir Nekhendzy, Hendrikus J. Lemmens, Amit R. Saxena, Brita M. Mittal, Edward J. Damrose, C. Kwang Sung, Raffick Bowen   +6 more
wiley   +1 more source

Impact of Respiratory Support Strategies on CO2 Variability During Therapeutic Hypothermia in Neonates With Asphyxia: Data From the German Hypothermia Registry

Acta Paediatrica, EarlyView.
ABSTRACT Aim To evaluate associations between respiratory support strategies, partial pressure of carbon dioxide (pCO2) variability and oxygen exposure in neonates with hypoxic–ischaemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). Methods This retrospective multicentre study used data from the German Hypothermia Registry, including ...
Sebiha Demir, Anne Groteklaes, Bettina Bohnhorst, Kirsten Glaser, Andreas Müller, Hemmen Sabir, Till Dresbach, on behalf of the German Hypothermia Registry, Milian Brasche, Nicolas Allgaier, Daniel Klotz, Norbert Teig, Katja Schneider, Hemmen Sabir, Sandra Holz, Birte Tröger, Thorsten Körner, Uwe Höpner, Marie Schmenk, Michael Hofmann, Mario Rüdiger, Julia Osterholt, Martin Berghäuser, Christopher Willerscheidt, Farina Morgenroth, Hans Jörg Bittrich, Steven Hébert, Arber Arapi, Anja Stein, Veit Lange, Gunnar Rau, Lisa‐Marie Stoek, Nikolas Hillenbrand, Matthias Reger, Susanne Schade, Jana Dieks, Heimke von Osten, Marita Horstkemper, Martin Blohm, Mario Lange, Bettina Bohnhorst, Manuela Friederike Richter, Simon Kranig, Maurice Petrasch, Nasenien Nourkami‐Tutdibi, Christine Pinkwart, Thomas Kriebel, Silvia Welcker, Nora Bonney, Angela Kribs, Clemens Andrée, Sophia Stadermann, Kirsten Glaser, Peter Jahn, Katrin Braun, Anna Eisenhardt, Alba Perez‐Ortiz, Nadine Mand, Ines Wallot, Timea Takacs, Anja Jäger, Oliver Schroers, Esther Schouten, Claudia Nussbaum, Kai Böckenholt, Rüdiger Wentzell, Guido Engelmann, Katherine Louise Kastor, Michael Schroth, Matthias Engler, Friederike Eichhorn, Moritz Rohrbach, Fabian Bärtling, Frank Dohle, Matthias Keller, Marion Weber, Verena Lehnerer, Anja Mayer, Marie‐Claire Detemple, Valentin Oellers, Markus Pingel, Friederike Eilbracht, Jutta Adler, Elena Eberle, Karoline Goj, Virginia Toth, Andrea Czoske, Cornelia Wiechers, Christiane Mayer, Anja Schumann, Patrick Salaschek, Janaina Rauch, Kai Hensel, Pia Paul   +93 more
wiley   +1 more source

Effect of hyperoxia on maximal oxygen uptake, blood acid-base balance, andlimitations to exercise tolerance [PDF]

, 2003
Hyperoxia, or an increase in inspired oxygen concentration, has been used by scientists to examine exercise metabolism and physical work capacity. It is apparent that hyperoxia increases VO2max and exercise tolerance due to an increase in O2 supply to ...
Astorino, Todd, Robergs, Robert A.
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