Results 41 to 50 of about 41,556 (244)

Postnatal hyperoxia or DEHP exposure leads to growth restriction and delayed lung development in newborn rats

Pediatrics and Neonatology, 2018
Background: Di-(2-ethylhexyl) phthalate (DEHP) is commonly used as a plasticizer in many medical devices. We previously showed that maternal DEHP exposure led to restricted growth and delayed lung maturation in newborn rats.
Zhong-Jie Liang, Qiu-Ping Wu, Bei-Tao Chen, Zhen-lang Lin, Jing Lin, Shang-Qin Chen   +5 more
doaj   +1 more source

Heat shock protein 70 protects the lungs from hyperoxic injury in a neonatal rat model of bronchopulmonary dysplasia.

PLoS ONE, 2023
Hyperoxia plays a significant role in the pathogenesis of lung injury, such as bronchopulmonary dysplasia (BPD), in premature infants or newborns. BPD management aims to minimize further injury, provide an optimal environment to support growth and ...
Cheng-Han Lee, Tzu-Cheng Su, Ming-Sheng Lee, Chien-Sheng Hsu, Rei-Cheng Yang, Jun-Kai Kao   +5 more
doaj   +1 more source

Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis. [PDF]

, 2020
BackgroundIn extremely premature infants, postnatal growth restriction (PNGR) is common and increases the risk of developing bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). Mechanisms by which poor nutrition impacts lung development are
Chiamvimonvat, Nipavan, Gerard, Kimberly, Halloran, Katrina, Hanhauser, Ashley, Lakshminrusimha, Satyan, Monacelli, Sveva, Steinhorn, Robin H, Thai, Phung N, Underwood, Mark A, Warford, Cris, Wedgwood, Stephen   +10 more
core  

Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila [PDF]

, 2008
Apolipoprotein D (ApoD) expression increases in several neurological disorders and in spinal cord injury. We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress ...
Ahn, Boyles, Boyles, Butterfield, D. W. Walker, Desai, Do Carmo, Duffy, Guti  rrez, J. Muffat, Kalman, Lechner, Morais Cabral, Navarro, Oakley, Pfaffl, Provost, Provost, Rassart, S. Benzer, Sanchez, Sutcliffe, Terrisse, Thomas, Thomas, Toroser, Vogt, Walker, Wallace, Walsh, Weech   +30 more
core   +3 more sources

Evaluation of ERK activity on Ischemic Tolerance-induced by Preconditioning with Intermittent Normobaric Hyperoxia in the Rat Model of Stroke [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: Recent studies indicate that hyperoxia has a significant therapeutic effect in the acute ischemic injury. The role of intracellular kinases, including ERK, has been posed in the phenomenon of ischemic tolerance.
Firoozeh Alavian, Sohrab Hajizadeh, Mohammad Javan, Roham Mazloom   +3 more
doaj  

Oxygen Variations—Insights into Hypoxia, Hyperoxia and Hyperbaric Hyperoxia—Is the Dose the Clue?

International Journal of Molecular Sciences, 2023
Molecular oxygen (O2) is one of the four most important elements on Earth (alongside carbon, nitrogen and hydrogen); aerobic organisms depend on it to release energy from carbon-based molecules [...]
Costantino Balestra, Simona Mrakic-Sposta, Fabio Virgili   +2 more
openaire   +4 more sources

Hyperoxia shows duration-dependent effects on the lengths of cell cycle phases in fetal cortical neural stem cells

Frontiers in Cell and Developmental Biology
Fetal neural stem cells (NSCs) physiologically reside under low-oxygen conditions (1%–5% of tissue pO2), but are often transferred and maintained under atmospheric oxygen levels of 21% pO2 (hyperoxia) for in vitro investigations.
Jennifer Lanto, Monika Maria Nicole Vehlken, Valeriia Abramenko, Alexander Storch, Alexander Storch, Franz Markert   +5 more
doaj   +1 more source

Upregulating carnitine palmitoyltransferase 1 attenuates hyperoxia-induced endothelial cell dysfunction and persistent lung injury

Respiratory Research, 2022
Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants that may cause long-term lung dysfunction. Accumulating evidence supports the vascular hypothesis of BPD, in which lung endothelial cell dysfunction drives this ...
Jason L. Chang, Jiannan Gong, Salu Rizal, Abigail L. Peterson, Julia Chang, Chenrui Yao, Phyllis A. Dennery, Hongwei Yao   +7 more
doaj   +1 more source

Protective Effect of Dexmedetomidine against Hyperoxia-Damaged Cerebellar Neurodevelopment in the Juvenile Rat

Antioxidants, 2023
Impaired cerebellar development of premature infants and the associated impairment of cerebellar functions in cognitive development could be crucial factors for neurodevelopmental disorders. Anesthetic- and hyperoxia-induced neurotoxicity of the immature
Robert Puls, Clarissa von Haefen, Christoph Bührer, Stefanie Endesfelder   +3 more
doaj   +1 more source

The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages

Antioxidants, 2021
Supplemental oxygen therapy with supraphysiological concentrations of oxygen (hyperoxia; >21% O2) is a life-saving intervention for patients experiencing respiratory distress.
Alex G. Gauthier, Jiaqi Wu, Mosi Lin, Ravikumar Sitapara, Abhijit Kulkarni, Ganesh A. Thakur, Edward E. Schmidt, Jeanette C. Perron, Charles R. Ashby, Lin L. Mantell   +9 more
doaj   +1 more source