Results 51 to 60 of about 28,027 (244)

Riociguat reduces and alters hyperoxia-induced lung inflammation.

, 2018
(A) Immunostaining for Mac-3, a macrophage marker. (B) The alveolar airspace macrophage population was increased by hyperoxia exposure as compared to normoxia. Administration of riociguat decreased macrophage count during hyperoxia.
Ronald Zambrano (5497406), Younghye Moon (200726), Shu Wu (492135), Shihua Luo (5497415), Yong Bao (296790), Luqing Wang (5257895), Merline Benny (5497403), Justin Percival (5497412), Ling Qin (68169), Fredrick Dapaah-Siakwan (5497409), Matthew R. Duncan (5497421), Keyur Donda (5497400), Karen Young (833929), Ruben Vaidya (5497418)   +13 more
core   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Riociguat prevents hyperoxia-ablated vascular development.

, 2018
(A) Immunofluorescence staining for von-Willebrand factor (vWF) (green signal). Vascular density (VD) was determined by counting vWF-positive vessels (B) Hyperoxia exposure in the presence of placebo significantly decreased VD as compared with normoxia ...
Ronald Zambrano (5497406), Younghye Moon (200726), Shu Wu (492135), Shihua Luo (5497415), Yong Bao (296790), Luqing Wang (5257895), Merline Benny (5497403), Justin Percival (5497412), Ling Qin (68169), Fredrick Dapaah-Siakwan (5497409), Matthew R. Duncan (5497421), Keyur Donda (5497400), Karen Young (833929), Ruben Vaidya (5497418)   +13 more
core   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

Neonatal hyperoxia exposure causes cerebellar lesions and behavioral abnormalities in rats

Scientific Reports
In humans, fetal cerebellar development peaks during the final stages of pregnancy. Preterm infants experience hyperoxia (excessive oxygen) outside the uterus. Hyperoxia exposure causes neurological deficits in preterm infants.
Sakiko Suzuki, Takahiro Kanzawa, Ryoko Shimode, Yukina Takamoto, Kazuto Ueda, Ryosuke Miura, Toshihiko Suzuki, Naoki Tajiri, Hideki Hida, Yoshiyuki Takahashi, Masahiro Hayakawa, Yoshiaki Sato   +11 more
doaj   +1 more source

Ventilatory response to isocapnic hyperoxia

, 1995
Breathing O2 for up to 1 h has been shown to either not influence or slightly increase (6–13%) minute ventilation. However, end-tidal PCO2 was not kept constant in these experiments.
O. Polo, C. E. Sullivan, H. Becker, S. G. McNamara, M. Berthon-Jones   +4 more
core   +1 more source

Francisella orientalis in Aquacultured Tilapia (Oreochromis spp.): A Case Work‐Up of Diagnostics and Pathologic Findings in the North Central Region (USA)

Journal of Fish Diseases, EarlyView.
ABSTRACT Tilapia (Oreochromis spp.) is an increasingly popular aquacultured fish worldwide. While tilapia enjoy a ‘hardy‐fish’ reputation among fish farmers, they are susceptible to a variety of infectious diseases that can be difficult to recognize pondside and have similarities in their gross presentations. This report describes gross and microscopic
S. E. Edmonds, N. O. Hickey, C. Q. Reis, I. Kamonchai, M. J. Kebus, A. P. Pessier, T. B. Waltzek, K. R. Snekvik   +7 more
wiley   +1 more source

Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats. [PDF]

PLoS ONE, 2008
BACKGROUND: Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization.
Céline Méhats, Marie-Laure Franco-Montoya, Olivier Boucherat, Emmanuel Lopez, Thomas Schmitz, Elodie Zana, Danièle Evain-Brion, Jacques Bourbon, Christophe Delacourt, Pierre-Henri Jarreau   +9 more
doaj   +1 more source

Severe hyperoxia increases hepatocyte apoptosis.

, 2014
A) TUNEL detection of apoptotic nuclei (arrow) in neonatal rat livers exposed to moderate and severe hyperoxia. a) ambient air; b) 60% hyperoxia; c) 95% hyperoxia; d) positive control; e) negative control. Scale bar: 50 µm, magnification 40x.
Guya Diletta Marconi (613851), Patrizia Zaramella (613856), Arben Dedja (613857), Raffaele De Caro (613858), Marianna De Colli (613853), Valentina Di Valerio (613854), Andrea Porzionato (613859), Susi Zara (613852), Veronica Macchi (450893), Monica Rapino (613855)   +9 more
core   +1 more source

Validating a Wearable Bluetooth Oximeter for Infants in the Neonatal Intensive Care Unit

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Introduction Oxygen is vital for life but the wrong amount of oxygen can lead to significant risk of morbidity and mortality. Preterm infants are at particular risk from both too little (hypoxia) and excess (hyperoxia) oxygen. In the neonatal intensive care unit (NICU), oxygen treatment is guided by oximetry derived from wired oximeters which ...
Amy Courtney, Ju Lee Oei
wiley   +1 more source