Results 71 to 80 of about 28,027 (244)

Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans

Experimental Physiology, EarlyView.
Abstract Sympathetic nervous system activation is a hallmark of high‐altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors – two excitatory pathways co‐activated by hypoxia – to sustained sympathoexcitation at altitude.
Michiel T. Ewalts, Lydia L. Simpson, Jack S. Talbot, Elliott J. Jenkins, Travis D. Gibbons, Connor A. Howe, Lauren E. Maier, Emily R. Vanden Berg, Alex M. Williams, Philip N. Ainslie, Samuel J. Oliver, Craig D. Steinback, Mike Stembridge, Jonathan P. Moore   +13 more
wiley   +1 more source

Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway

Molecular Medicine
The lack of knowledge about the mechanism of hyperoxia-induced intestinal injury has attracted considerable attention, due to the potential for this condition to cause neonatal complications. This study aimed to explore the relationship between hyperoxia-
Yanping Liu, Tianming Li, Changping Niu, Zhengwei Yuan, Siyu Sun, Dongyan Liu   +5 more
doaj   +1 more source

Effects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia

BMC Pulmonary Medicine, 2019
Background This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II) cells after exposure to ...
Hongyan Lu, Xiaoqing Chen, Yanmin Lu, Haitao Zhu, Wei Tang, Qiuxia Wang   +5 more
doaj   +1 more source

Exercise intolerance and impaired aerobic capacity in heart transplant recipients

Experimental Physiology, EarlyView.
Abstract Heart transplant recipients exhibit reduced exercise tolerance and persistently diminished aerobic capacity despite exercise training. Exercise tolerance depends on integrated oxygen transport and utilization, which are impaired in heart transplant recipients.
Fred W. Kolkhorst, Daniel T. Cannon, Harry B. Rossiter   +2 more
wiley   +1 more source

PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia

Redox Biology
Diastolic dysfunction is increasingly common in preterm infants exposed to supplemental oxygen (hyperoxia). Previous studies in neonatal mice showed hyperoxia suppresses fatty acid synthesis genes required for proliferation and survival of atrial ...
E. David Cohen, Kyle Roethlin, Min Yee, Collynn F. Woeller, Paul S. Brookes, George A. Porter, Jr., Michael A. O'Reilly   +6 more
doaj   +1 more source

Probability of cerebellar hypoxia and hyperoxia over disease time-course.

, 2016
Probability of hypoxia (A) and hyperoxia (B), calculated by dividing the total number of significant hypoxic (or hyperoxic) days by the total measurements. There is a higher probability of hypoxia than hyperoxia.
Nabeela Nathoo (740843), Ying Wu (19057), Thomas W. Johnson (437931), V. Wee Yong (418566), James A. Rogers (740844), Jeff F. Dunn (122387)   +5 more
core   +1 more source

Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study

Critical Care, 2018
Background Providing supplemental oxygen is fundamental in the management of mechanically ventilated patients. Increasing amounts of data show worse clinical outcomes associated with hyperoxia.
David Page, Enyo Ablordeppey, Brian T. Wessman, Nicholas M. Mohr, Stephen Trzeciak, Marin H. Kollef, Brian W. Roberts, Brian M. Fuller   +7 more
doaj   +1 more source

The role of acid‐base balance in cerebrovascular and ventilatory responses to CO2 during 10 h normobaric hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend During 10 h exposures to normobaric hypoxia exposure there was a selective leftward shift in ventilatory response to hyperoxic hypercapnic rebreathing, but not the cerebrovascular response. The key findings are that the resetting of the central chemoreflex to lower PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$ during early hypoxic ...
Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui‐Lin Fan   +3 more
wiley   +1 more source

A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung

BMC Cell Biology, 2011
Background Transforming growth factor-beta 1 (TGF-β1) has been implicated in hyperoxia-induced cell death and impaired alveolarization in the developing lung.
Li Zhang, Choo-Wing Rayman, Sun Huanxing, Sureshbabu Angara, Sakurai Reiko, Rehan Virender K, Bhandari Vineet   +6 more
doaj   +1 more source

Hyperoxia inhibits several critical aspects of vascular development

, 2007
Normal human retinal vascular development uses angiogenesis and vasculogenesis, both of which are interrupted in the vaso-obliteration phase of retinopathy of prematurity (ROP). Canine oxygen-induced retinopathy (OIR) closely resembles human ROP.
Lutty, Gerard A., Koichi Uno, Grebe, Rhonda, Rhonda Grebe, Merges, Carol A., Uno, Koichi, Carol A. Merges, Tarl W. Prow, Gerard A. Lutty, Prow, Tarl W.   +9 more
core   +1 more source