Results 81 to 90 of about 19,463 (207)

Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley   +1 more source

Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats

Scientific Reports
Premature infants are often exposed to hyperoxia. However, there is limited data regarding the mechanistic underpinnings linking neonatal hyperoxia exposure and its contribution to cardio-renal dysfunction in adults born preterm.
Marissa J. DeFreitas, Elaine L. Shelton, Augusto F. Schmidt, Sydne Ballengee, Runxia Tian, PingPing Chen, Mayank Sharma, Amanda Levine, Emily Davidovic Katz, Claudia Rojas, Carolyn L. Abitbol, Juanita Hunter, Shathiyah Kulandavelu, Shu Wu, Karen C. Young, Merline Benny   +15 more
doaj   +1 more source

The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice

Respiratory Research, 2018
Background Exposure to high levels of oxygen (hyperoxia) after birth leads to lung injury. Our aims were to investigate the modulation of myeloid cell sub-populations and the reduction of fibrosis in the lungs following administration of human ...
Ali Al-Rubaie, Andrea F. Wise, Foula Sozo, Robert De Matteo, Chrishan S. Samuel, Richard Harding, Sharon D. Ricardo   +6 more
doaj   +1 more source

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, Volume 183, Issue 17, Page 5355-5371, September 2026.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

Respiratory control at high altitude: The chemoreceptor as a paragon of plasticity

The Journal of Physiology, EarlyView.
Jerome A. Dempsey
wiley   +1 more source

Efficacy of a Nursing Checklist During Mechanical Ventilation in Patients With Severe Pneumonia

Nursing in Critical Care, Volume 31, Issue 5, September 2026.
ABSTRACT Background Severe pneumonia is a respiratory disease associated with high morbidity and mortality, often necessitating mechanical ventilation. However, prolonged mechanical ventilation is associated with an increased risk of complications and higher use of healthcare resources.
Miao Guo, Li Qiao, Xiaohui Xing, Jing Zhao, Zheng Wang   +4 more
wiley   +1 more source

Effectiveness of intermittent hypoxia on muscle recovery in rats: A systematic review

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1539-1547, August 2026.
This systematic review of animal studies evaluated intermittent hypobaric hypoxia (IHH), cold exposure, and their combinations, with or without exercise, on skeletal muscle recovery. IHH enhanced muscle regeneration, reduced fibrosis, improved contractile force, and maintained oxidative capacity, while cold exposure increased mitochondrial activity but
Sebastian Philippe Hansen Quiblier, María García‐Arrabé, Diego Domínguez‐Balmaseda, Guillermo García‐Pérez‐de‐Sevilla   +3 more
wiley   +1 more source

Energy Allocation Explains How Protozoan Phenotypic Traits Change in Response to Temperature and Resource Supply

Ecology and Evolution, Volume 16, Issue 8, August 2026.
When cultures of the microorganism Tetrahymena pyriformis are transferred to environments with different temperature and resource levels, the phenotypic traits of the microorganisms—including cell size, metabolic rate, and movement speed—change.
Andrea Perna, Enrico S. Rivoli, Julia Reiss, Daniel M. Perkins   +3 more
wiley   +1 more source

HS-GC–MS analysis of volatile organic compounds after hyperoxia-induced oxidative stress: a validation study

Intensive Care Medicine Experimental
Background Exhaled volatile organic compounds (VOCs), particularly hydrocarbons from oxidative stress-induced lipid peroxidation, are associated with hyperoxia exposure.
Thijs A. Lilien, Dominic W. Fenn, Paul Brinkman, Laura A. Hagens, Marry R. Smit, Nanon F. L. Heijnen, Job B. M. van Woensel, Lieuwe D. J. Bos, Reinout A. Bem, the DARTS study group   +9 more
doaj   +1 more source

Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review

eFood, Volume 7, Issue 4, August 2026.
Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu, Manxi Wu, Hui Xu, Jiebiao Chen, Wen Cai, Han Yang, Hujing Cao, Xinlin Huang, Jinping Cao, Chongde Sun, Yue Wang, Dongliang Li   +11 more
wiley   +1 more source