Results 81 to 90 of about 41,556 (244)

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Effects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia

BMC Pulmonary Medicine, 2019
Background This study aims to investigate the effects of CCAAT/enhancer binding protein alpha (C/EBPα) overexpression on cell proliferation, apoptosis and surfactant protein-C(SP-C) in alveolar epithelial type II (AEC II) cells after exposure to ...
Hongyan Lu, Xiaoqing Chen, Yanmin Lu, Haitao Zhu, Wei Tang, Qiuxia Wang   +5 more
doaj   +1 more source

Elevated carotid body tonic activity contributes to ventilatory acclimatization and de‐acclimatization to high altitude at rest and during exercise

The Journal of Physiology, EarlyView.
Abstract figure legend Participants spent 13 days at high altitude (3800 m), where the reduced inspired oxygen pressure (↓PiO2$ \downarrow {P_{{\mathrm{i}}{{\mathrm{O}}_2}}}$) which elicited ventilatory acclimatization and increased inhibition of ventilation by transient hyperoxia (ΔV̇E$\Delta {\dot V_{\mathrm{E}}}$).
Ayechew A. Getu, L. Madden Brewster, Travis D. Gibbons, James D. Anholm, Michael Stembridge, Philip N. Ainslie, Jay M. J. R. Carr   +6 more
wiley   +1 more source

PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia

Redox Biology
Diastolic dysfunction is increasingly common in preterm infants exposed to supplemental oxygen (hyperoxia). Previous studies in neonatal mice showed hyperoxia suppresses fatty acid synthesis genes required for proliferation and survival of atrial ...
E. David Cohen, Kyle Roethlin, Min Yee, Collynn F. Woeller, Paul S. Brookes, George A. Porter, Jr., Michael A. O'Reilly   +6 more
doaj   +1 more source

Emergency department hyperoxia is associated with increased mortality in mechanically ventilated patients: a cohort study

Critical Care, 2018
Background Providing supplemental oxygen is fundamental in the management of mechanically ventilated patients. Increasing amounts of data show worse clinical outcomes associated with hyperoxia.
David Page, Enyo Ablordeppey, Brian T. Wessman, Nicholas M. Mohr, Stephen Trzeciak, Marin H. Kollef, Brian W. Roberts, Brian M. Fuller   +7 more
doaj   +1 more source

Hyperoxia as a driver of gut dysbiosis. [PDF]

Front Microbiol
The mammalian colon lumen exists in a highly anaerobic environment (oxygen partial pressure (PO 2 ) < 1 mmHg), which promotes the growth of beneficial obligate anaerobes (OA) while limiting the expansion of pathogenic facultative anaerobes (FA).
Wu H, Zeng W, Dai N, Gu J, He Y, Qin H, Lin L, Fu X, Fu B, Xing Z.   +9 more
europepmc   +3 more sources

Hyperoxia Causes Mitochondrial Fragmentation in Pulmonary Endothelial Cells by Increasing Expression of Pro-Fission Proteins [PDF]

, 2018
Objective—We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. Approach and Results—Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and ...
Audi, Said H., Beyer, Andreas M., Clough, Anne V., Durand, Matthew J., Ebben, Johnathan D., Hill, R. Blake, Jacobs, Elizabeth R., Ma, Cui, Medhora, Meetha, Terashvili, Maia, Toro, Laura Norwood, Zhu, Daling   +11 more
core   +1 more source

Breathing irregularities and postnatal hypoxaemia in an experimental model of essential hypertension

The Journal of Physiology, EarlyView.
Abstract figure legend Neonatal spontaneously hypertensive rats (SHRs) exhibit inherent respiratory dysfunction in early life, including oscillatory breathing patterns and apnoeic events that cause oxygen desaturation and brain hypoxia, in addition to an impaired hypoxic ventilatory response.
Beatriz N. Vieira, Letícia R. Mendes, Sarah G. Mariano, Isabela P. Leirão, Emilson D. Pereira‐Junior, Milede H. Saraiva Paes, Pedro L. Katayama, Daniel B. Zoccal   +7 more
wiley   +1 more source

A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung

BMC Cell Biology, 2011
Background Transforming growth factor-beta 1 (TGF-β1) has been implicated in hyperoxia-induced cell death and impaired alveolarization in the developing lung.
Li Zhang, Choo-Wing Rayman, Sun Huanxing, Sureshbabu Angara, Sakurai Reiko, Rehan Virender K, Bhandari Vineet   +6 more
doaj   +1 more source

Lung Circulation Modeling: Status and Prospect [PDF]

, 2006
Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are ...
Audi, Said H., Clough, Anne V., Krenz, Gary S., Molthen, Robert C.   +3 more
core   +1 more source